Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines

Ahu PAKDEMİRLİ; Caner KARACA; Tolga SEVER; Ezgi DAŞKIN; Asım LEBLEBİCİ; Türkan YİĞİTBAŞI; Yasemin BAŞBINAR

doi:https://doi.org/10.3906/sag-1907-173

Makale detayları

Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines

Yazarlar:

Ahu PAKDEMİRLİ | Caner KARACA | Tolga SEVER | Ezgi DAŞKIN | Asım LEBLEBİCİ | Türkan YİĞİTBAŞI | Yasemin BAŞBINAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2020 Vol.50 Issue 1, pp.271-276

Belge Tipi:

Makale

Yayın Tarihi:

12/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749734

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1907-173

Özet:

 

Background/aim: Natural products are popular insights for researchers to investigate promising anti-cancer agents since some of these substances have lesser adverse effects restricting the treatment than traditional chemotherapeutic agents. A well-known monoterpene Carvacrol, widely consumed in Mediterranean cuisine and lower risks of cancer, has efficient anticancer effects. However, the mechanism of action is yet to be discovered. Materials  and  methods:  The  investigation  aims  to  illuminate  a  new  perceptive  in  the  role  of  this  substance  on  colorectal  cancer  treatment,  by  the  means  of  differences  in  a  well-defined  range  of  soluble  factors.  Carvacrol  effect  on  both  HT-29  and  HCT-116  cell  lines was evaluated on proliferation and the IC50 values were calculated by the RTCA xCELLigence device. Then MAGPIX assay was performed to obtain the changes in soluble factors of the cell lines. Results: The Multiplexing assay suggests some of these factors were altered in favor of surviving and proliferation in aggressive cell line HCT-116 whereas they were altered against these characters in HT-29, were correlated with the increased IC50 concentration of HCT-116 in carvacrol treatment. Conclusion: The current study indicates that differences in the levels of these soluble factors could modulate the anticancer effect related to carvacrol.

Makale detayları

Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines

Yazarlar: Ahu PAKDEMİRLİ | Caner KARACA | Tolga SEVER | Ezgi DAŞKIN | Asım LEBLEBİCİ | Türkan YİĞİTBAŞI | Yasemin BAŞBINAR

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2020 Vol.50 Issue 1, pp.271-276

Belge Tipi: Makale

Yayın Tarihi: 12/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000749734

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

DOI: https://doi.org/10.3906/sag-1907-173

Sayı

Yazarlar:

Ahu PAKDEMİRLİ | Caner KARACA | Tolga SEVER | Ezgi DAŞKIN | Asım LEBLEBİCİ | Türkan YİĞİTBAŞI | Yasemin BAŞBINAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2020 Vol.50 Issue 1, pp.271-276

Belge Tipi:

Makale

Yayın Tarihi:

12/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749734

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

DOI:

https://doi.org/10.3906/sag-1907-173