The association between C-reactive protein/albumin ratio and aortic arch calcification in acute coronary syndrome patients

Uğur Köktürk; Fahri Çakan

Makale detayları

The association between C-reactive protein/albumin ratio and aortic arch calcification in acute coronary syndrome patients

Yazarlar:

Uğur Köktürk | Fahri Çakan

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Cukurova Medical Journal Vol.49 Issue 2, pp.382-390

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001320795

pISSN:

2602-3032

Anahtar kelimeler:

Özet:

 Purpose: We evaluated the association between the severity of aortic arch calcification AAC and C-reactive proteinalbumin ratio CAR in acute coronary syndrome ACS patients. Materials and Methods: 288 patients who presented with ACS and underwent coronary angiography were enrolled analysis. CAR was calculated as serum CRPalbumin x 10. The AAC was separated into four groups 0 to 3: Grade 0-1 AAC was defined as the non-severe AAC group, and those with grade 2-3 AAC were defined as the severe AAC group. Results: CRP and CAR were significantly higher in the severe AAC group than in the non-severe AAC group. Multivariate analysis determined that CAR and age were positively associated in ACS patients as an independent predictor of severe AAC. CAR area under the curve AUC and CRP AUC demonstrated parallel curves compared to albumin levels, indicating higher statistical significance. The AUC for albumin was 0.349 95 CI: 0.286-0.413. The AUC for CAR was 0.695, 95 CI 0.625 to 0.753, for CRP the AUC was 0.684 95 CI: 0.620-0.748. After stratification into 2 groups according to the CAR cut-off value 1.664, the rate of severe AAC was importantly often in high CAR patients compared to in low CAR patients 56.7 vs 23.7. Conclusion: CAR, an easily calculable, repeatable, and valid surrogate marker of inflammation, can be used reliably to indicate severe AAC in ACS patients.

 Purpose: We evaluated the association between the severity of aortic arch calcification AAC and C-reactive proteinalbumin ratio CAR in acute coronary syndrome ACS patients. Materials and Methods: 288 patients who presented with ACS and underwent coronary angiography were enrolled analysis. CAR was calculated as serum CRPalbumin x 10. The AAC was separated into four groups 0 to 3: Grade 0-1 AAC was defined as the non-severe AAC group, and those with grade 2-3 AAC were defined as the severe AAC group. Results: CRP and CAR were significantly higher in the severe AAC group than in the non-severe AAC group. Multivariate analysis determined that CAR and age were positively associated in ACS patients as an independent predictor of severe AAC. CAR area under the curve AUC and CRP AUC demonstrated parallel curves compared to albumin levels, indicating higher statistical significance. The AUC for albumin was 0.349 95 CI: 0.286-0.413. The AUC for CAR was 0.695, 95 CI 0.625 to 0.753, for CRP the AUC was 0.684 95 CI: 0.620-0.748. After stratification into 2 groups according to the CAR cut-off value 1.664, the rate of severe AAC was importantly often in high CAR patients compared to in low CAR patients 56.7 vs 23.7. Conclusion: CAR, an easily calculable, repeatable, and valid surrogate marker of inflammation, can be used reliably to indicate severe AAC in ACS patients.

 Purpose: We evaluated the association between the severity of aortic arch calcification AAC and C-reactive proteinalbumin ratio CAR in acute coronary syndrome ACS patients. Materials and Methods: 288 patients who presented with ACS and underwent coronary angiography were enrolled analysis. CAR was calculated as serum CRPalbumin x 10. The AAC was separated into four groups 0 to 3: Grade 0-1 AAC was defined as the non-severe AAC group, and those with grade 2-3 AAC were defined as the severe AAC group. Results: CRP and CAR were significantly higher in the severe AAC group than in the non-severe AAC group. Multivariate analysis determined that CAR and age were positively associated in ACS patients as an independent predictor of severe AAC. CAR area under the curve AUC and CRP AUC demonstrated parallel curves compared to albumin levels, indicating higher statistical significance. The AUC for albumin was 0.349 95 CI: 0.286-0.413. The AUC for CAR was 0.695, 95 CI 0.625 to 0.753, for CRP the AUC was 0.684 95 CI: 0.620-0.748. After stratification into 2 groups according to the CAR cut-off value 1.664, the rate of severe AAC was importantly often in high CAR patients compared to in low CAR patients 56.7 vs 23.7. Conclusion: CAR, an easily calculable, repeatable, and valid surrogate marker of inflammation, can be used reliably to indicate severe AAC in ACS patients.

 Amaç: Akut koroner sendrom AKS hastalarında aortik ark kalsifikasyonunun ciddiyeti AAC ile C-reaktif proteinAlbümin oranı CAR arasındaki ilişkiyi değerlendirdik. Gereç ve Yöntem: AKS ile başvuran ve koroner anjiyografi yapılan 288 hasta analize dahil edildi. CAR serum CRPalbümin x 10 olarak hesaplandı. AAC dört gruba ayrıldı 0 ila 3: Grade 0-1 AAC, ciddi olmayan AAC grubu olarak; grade 2-3 AAC olanlar ise ciddi AAC grubu olarak tanımlandı. Bulgular: CRP ve CAR, ciddi AAC grubunda, ciddi olmayan AAC grubuna göre anlamlı derecede yüksekti. Çok değişkenli analiz, AKS hastalarında ciddi AACnin bağımsız bir belirleyicisi olarak CAR ve yaşın pozitif ilişkili olduğunu belirledi. Eğri altındaki CAR alanı AUC ve CRP AUC, albümin seviyesine kıyasla paralel eğriler gösterdi ve bu da daha yüksek istatistiksel anlamlılığa işaret ettiğini gösterdi. Albüminin AUCsi 0,349du 95 GA: 0,286-0,413. CAR için AUC 0,695, 95 GA 0,625 ila 0,753, CRP için AUC 0,684 95 GA: 0,620-0,748 idi. CAR kesme değerine 1,664 göre 2 gruba ayrıldıktan sonra, ciddi AAC oranı, yüksek CAR hastalarında düşük CAR hastalarına kıyasla önemli ölçüde daha sık görüldü 56,7 vs 23,7. Sonuç: Kolayca hesaplanabilen, tekrarlanabilir ve geçerli bir inflamasyon belirteci olan CAR, AKS hastalarında ciddi AACyi öngörmek için güvenilir bir şekilde kullanılabilir.

Makale detayları

The association between C-reactive protein/albumin ratio and aortic arch calcification in acute coronary syndrome patients

Yazarlar:

Uğur Köktürk | Fahri Çakan

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Cukurova Medical Journal Vol.49 Issue 2, pp.382-390

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001320795

pISSN:

2602-3032

C-Reactive protein

acute myocardial infarction

aortic arch calcificationC-reaktif protein

aortik ark kalsifikasyonu

akut koroner sendrom

Sayı

Makale detayları

The association between C-reactive protein/albumin ratio and aortic arch calcification in acute coronary syndrome patients

Yazarlar: Uğur Köktürk | Fahri Çakan

Yayıncı: Cukurova University

Ana Başlıklar: Klinik Tıp Bilimleri (Diğer)

Dergi: Cukurova Medical Journal Vol.49 Issue 2, pp.382-390

Belge Tipi: Makale

Yayın Tarihi: 6/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001320795

pISSN: 2602-3032

C-Reactive protein

acute myocardial infarction

aortic arch calcificationC-reaktif protein

aortik ark kalsifikasyonu

akut koroner sendrom

Sayı

Yazarlar:

Uğur Köktürk | Fahri Çakan

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Cukurova Medical Journal Vol.49 Issue 2, pp.382-390

Belge Tipi:

Makale

Yayın Tarihi:

6/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001320795

pISSN:

2602-3032