Ceragenins exhibiting promising antimicrobial activity against various multidrug resistant Gram negative bacteria

Özlem OYARDI; Paul B. SAVAGE; Alper AKÇALI; Zayre ERTURAN; Çağla BOZKURT-GÜZEL

Makale detayları

Ceragenins exhibiting promising antimicrobial activity against various multidrug resistant Gram negative bacteria

Yazarlar:

Özlem OYARDI | Paul B. SAVAGE | Alper AKÇALI | Zayre ERTURAN | Çağla BOZKURT-GÜZEL

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

İstanbul Journal of Pharmacy 2018 Vol.48 Issue 3, pp.68-72

Belge Tipi:

Makale

Yayın Tarihi:

11/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000513048

Sıklık:

Aylık

eISSN:

2587-2087

Özet:

 



DOI: 10.26650/IstanbulJPharm.2018.400730



Ceragenins are novel promising agents for
the treatment of infections caused by multi-drug resistant microorganisms.
Since colistin resistance has become a worldwide problem, the need for new
treatment agents has been increasing steadily. Therefore, this study aimed to
investigate in vitro antimicrobial activities of ceragenins (Cationic Steroid
Antibiotics) (CSA-8, CSA-13, CSA-142 and CSA-192) against multidrug resistant
Gram negative isolates from Turkey. Experiments were performed by using broth
microdilution method against Klebsiella pneumoniae, Morganella morganii,
Pseudomonas aeruginosa and Stenotrophomonas maltophilia isolates. All
microorganisms except for three isolates were identified as multidrug
resistant. Among tested ceragenins, CSA-13 showed the best results (MIC: 8-64
µg/ml). Nevertheless, the antimicrobial activity of CSA-8 was not significant.
In conclusion, ceragenins appear to be a good candidate as antimicrobial
therapy in the presence of multidrug (including colistin) resistant
microorganisms.



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Makale detayları

Ceragenins exhibiting promising antimicrobial activity against various multidrug resistant Gram negative bacteria

Yazarlar: Özlem OYARDI | Paul B. SAVAGE | Alper AKÇALI | Zayre ERTURAN | Çağla BOZKURT-GÜZEL

Yayıncı: Istanbul University

Ana Başlıklar: Sağlık teşvikleri

Dergi: İstanbul Journal of Pharmacy 2018 Vol.48 Issue 3, pp.68-72

Belge Tipi: Makale

Yayın Tarihi: 11/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000513048

Sıklık: Aylık

eISSN: 2587-2087

Sayı

Yazarlar:

Özlem OYARDI | Paul B. SAVAGE | Alper AKÇALI | Zayre ERTURAN | Çağla BOZKURT-GÜZEL

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

İstanbul Journal of Pharmacy 2018 Vol.48 Issue 3, pp.68-72

Belge Tipi:

Makale

Yayın Tarihi:

11/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000513048

Sıklık:

Aylık

eISSN:

2587-2087