Etiological evaluation of the elevated transaminases in children

Aslıhan SANRI; Ceyda TUNA KIRSAÇLIOĞLU; Emre SANRI; Tülin Revide ŞAYLI

doi:https://doi.org/10.7197/cmj.vi.593477

Makale detayları

Etiological evaluation of the elevated transaminases in children

Yazarlar:

Aslıhan SANRI | Ceyda TUNA KIRSAÇLIOĞLU | Emre SANRI | Tülin Revide ŞAYLI

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Cumhuriyet Medical Journal 2020 Vol.42 Issue 1, pp.56-64

Belge Tipi:

Makale

Yayın Tarihi:

5/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000922423

DOI:

https://doi.org/10.7197/cmj.vi.593477

Özet:

 


Objective: We aimed to determine the etiology of hypertransaminasemia in children, demonstrate the differences according to the age and  evaluate course of transaminases.Method: We retrospectively analyzed the medical records of children who presented with elevated transaminase levels for at least 2 months, aged between 3 months and 18 years, for demographic features, laboratory, radiologic and histopathological findings.Results: Among total 292 children, 194 (66.4%) were male and 98 (33.6%) were female. The mean age was 6.5±5.4 years. The 45.9% of the children had no complaints at presentation. Majority of the patients had mildly elevated transaminases (81.6%). The most common etiology was non-alcoholic fatty liver disease (NAFLD) (25.7%).  The NAFLD was more prevelant in patients older than 5 years-old (p<0.001). The second cause was infectious diseases (97.8% were viral infections) and more prevelant in patients younger than 2 years-old (p=0.043). In 34.1 % of the children, no overt cause of hypertransaminasemia was identified. The patients with  unidentified etiology were significantly younger, but had higher mean aspartate aminotransferase (AST) levels than the patients in whom the etiology was identified (p= <0.0001, p=0.008 respectively). The normalization of transaminases was seen in 40.4% of the patients at mean 5.4±4.4 months. The shortest normalization time was observed in drug related liver injury (DILI) among all other etiologies (p=0.015).  Conclusions: The most common cause of hypertransaminasemia in childhood were NAFLD and viral infections, which varies by age. A stepwise approachment to hypertransaminasemia leads to early diagnosis. 


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Makale detayları

Etiological evaluation of the elevated transaminases in children

Yazarlar: Aslıhan SANRI | Ceyda TUNA KIRSAÇLIOĞLU | Emre SANRI | Tülin Revide ŞAYLI

Ana Başlıklar: Sağlık teşvikleri

Dergi: Cumhuriyet Medical Journal 2020 Vol.42 Issue 1, pp.56-64

Belge Tipi: Makale

Yayın Tarihi: 5/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000922423

DOI: https://doi.org/10.7197/cmj.vi.593477

Sayı

Yazarlar:

Aslıhan SANRI | Ceyda TUNA KIRSAÇLIOĞLU | Emre SANRI | Tülin Revide ŞAYLI

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Cumhuriyet Medical Journal 2020 Vol.42 Issue 1, pp.56-64

Belge Tipi:

Makale

Yayın Tarihi:

5/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000922423

DOI:

https://doi.org/10.7197/cmj.vi.593477