Evaluation of anti-emetic activity of Syzygium aromaticum extracts in chick and rat models of emesis

Long Chiau Ming

Makale detayları

Evaluation of anti-emetic activity of Syzygium aromaticum extracts in chick and rat models of emesis

Yazarlar:

Long Chiau Ming

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 4, pp.1231-1243

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347038

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Emesis, a multifaceted physiological response, presents significant challenges in clinical scenarios such as chemotherapy-induced nausea and vomiting. Novel antiemetic interventions are imperative to enhance patient care and well-being. This study investigated the antiemetic potential of Syzygium aromaticum clove extract using a comprehensive approach involving phytochemical analysis and animal models of emesis. Using chick model of emesis, male chicks aged 4 days were assigned to groups receiving different treatments, including copper sulfate, clove extract and metoclopramide. The effectiveness of treatments were assessed by monitoring retching frequency and changes in feed intake. Similarly, albino Wistar rats were used modelling emesis in rat and were categorized into groups receiving cisplatin, clove extract and metoclopramide as a standard control. Emetic responses were evaluated through pica behaviour assessment. In the chick model, a single dose of the following drugs was administered, either orally p.o or intra-peritoneally i.p as following: Copper sulfate at 50mgkg p.o., Clove extract at 50mgkg p.o, and Metoclopramide at 100mgkg i.p. For the rat animal model, a once-daily dosage of cisplatin at 3 mgkg i.p, metoclopramide at 2.5 mgkg i.p., and clove extract at 100 mgkg p.o. for three consecutive days were administered. Phytochemical analysis unveiled the intricate composition of clove extract, with eugenol standing out as a prominent constituent 71.56. In the chick model, clove extract reduced copper sulfate-induced retching, displaying an impressive 84.63 inhibition rate. Similarly, in the rat model, the extract significantly alleviated cisplatin-induced pica behavior, with a statistically significant reduction in retching instances P  0.05. Clove extracts multifaceted antiemetic effects, attributed to eugenol and other bioactive components, provide promising insights for managing emesis. The studys findings hold translational significance, suggesting clove extracts potential as a complementary antiemetic therapy alongside conventional treatments. The identification of eugenol as a key contributor warrants further investigation into molecular mechanisms, offering hope for effectively managing chemotherapy-induced nausea and vomiting.

 Emesis, a multifaceted physiological response, presents significant challenges in clinical scenarios such as chemotherapy-induced nausea and vomiting. Novel antiemetic interventions are imperative to enhance patient care and well-being. This study investigated the antiemetic potential of Syzygium aromaticum clove extract using a comprehensive approach involving phytochemical analysis and animal models of emesis. Using chick model of emesis, male chicks aged 4 days were assigned to groups receiving different treatments, including copper sulfate, clove extract and metoclopramide. The effectiveness of treatments were assessed by monitoring retching frequency and changes in feed intake. Similarly, albino Wistar rats were used modelling emesis in rat and were categorized into groups receiving cisplatin, clove extract and metoclopramide as a standard control. Emetic responses were evaluated through pica behaviour assessment. In the chick model, a single dose of the following drugs was administered, either orally p.o or intra-peritoneally i.p as following: Copper sulfate at 50mgkg p.o., Clove extract at 50mgkg p.o, and Metoclopramide at 100mgkg i.p. For the rat animal model, a once-daily dosage of cisplatin at 3 mgkg i.p, metoclopramide at 2.5 mgkg i.p., and clove extract at 100 mgkg p.o. for three consecutive days were administered. Phytochemical analysis unveiled the intricate composition of clove extract, with eugenol standing out as a prominent constituent 71.56. In the chick model, clove extract reduced copper sulfate-induced retching, displaying an impressive 84.63 inhibition rate. Similarly, in the rat model, the extract significantly alleviated cisplatin-induced pica behavior, with a statistically significant reduction in retching instances P  0.05. Clove extracts multifaceted antiemetic effects, attributed to eugenol and other bioactive components, provide promising insights for managing emesis. The studys findings hold translational significance, suggesting clove extracts potential as a complementary antiemetic therapy alongside conventional treatments. The identification of eugenol as a key contributor warrants further investigation into molecular mechanisms, offering hope for effectively managing chemotherapy-induced nausea and vomiting.

 Emesis, a multifaceted physiological response, presents significant challenges in clinical scenarios such as chemotherapy-induced nausea and vomiting. Novel antiemetic interventions are imperative to enhance patient care and well-being. This study investigated the antiemetic potential of Syzygium aromaticum clove extract using a comprehensive approach involving phytochemical analysis and animal models of emesis. Using chick model of emesis, male chicks aged 4 days were assigned to groups receiving different treatments, including copper sulfate, clove extract and metoclopramide. The effectiveness of treatments were assessed by monitoring retching frequency and changes in feed intake. Similarly, albino Wistar rats were used modelling emesis in rat and were categorized into groups receiving cisplatin, clove extract and metoclopramide as a standard control. Emetic responses were evaluated through pica behaviour assessment. In the chick model, a single dose of the following drugs was administered, either orally p.o or intra-peritoneally i.p as following: Copper sulfate at 50mgkg p.o., Clove extract at 50mgkg p.o, and Metoclopramide at 100mgkg i.p. For the rat animal model, a once-daily dosage of cisplatin at 3 mgkg i.p, metoclopramide at 2.5 mgkg i.p., and clove extract at 100 mgkg p.o. for three consecutive days were administered. Phytochemical analysis unveiled the intricate composition of clove extract, with eugenol standing out as a prominent constituent 71.56. In the chick model, clove extract reduced copper sulfate-induced retching, displaying an impressive 84.63 inhibition rate. Similarly, in the rat model, the extract significantly alleviated cisplatin-induced pica behavior, with a statistically significant reduction in retching instances P  0.05. Clove extracts multifaceted antiemetic effects, attributed to eugenol and other bioactive components, provide promising insights for managing emesis. The studys findings hold translational significance, suggesting clove extracts potential as a complementary antiemetic therapy alongside conventional treatments. The identification of eugenol as a key contributor warrants further investigation into molecular mechanisms, offering hope for effectively managing chemotherapy-induced nausea and vomiting.

 Emesis, a multifaceted physiological response, presents significant challenges in clinical scenarios such as chemotherapy-induced nausea and vomiting. Novel antiemetic interventions are imperative to enhance patient care and well-being. This study investigated the antiemetic potential of Syzygium aromaticum clove extract using a comprehensive approach involving phytochemical analysis and animal models of emesis. Using chick model of emesis, male chicks aged 4 days were assigned to groups receiving different treatments, including copper sulfate, clove extract and metoclopramide. The effectiveness of treatments were assessed by monitoring retching frequency and changes in feed intake. Similarly, albino Wistar rats were used modelling emesis in rat and were categorized into groups receiving cisplatin, clove extract and metoclopramide as a standard control. Emetic responses were evaluated through pica behaviour assessment. In the chick model, a single dose of the following drugs was administered, either orally p.o or intra-peritoneally i.p as following: Copper sulfate at 50mgkg p.o., Clove extract at 50mgkg p.o, and Metoclopramide at 100mgkg i.p. For the rat animal model, a once-daily dosage of cisplatin at 3 mgkg i.p, metoclopramide at 2.5 mgkg i.p., and clove extract at 100 mgkg p.o. for three consecutive days were administered. Phytochemical analysis unveiled the intricate composition of clove extract, with eugenol standing out as a prominent constituent 71.56. In the chick model, clove extract reduced copper sulfate-induced retching, displaying an impressive 84.63 inhibition rate. Similarly, in the rat model, the extract significantly alleviated cisplatin-induced pica behavior, with a statistically significant reduction in retching instances P  0.05. Clove extracts multifaceted antiemetic effects, attributed to eugenol and other bioactive components, provide promising insights for managing emesis. The studys findings hold translational significance, suggesting clove extracts potential as a complementary antiemetic therapy alongside conventional treatments. The identification of eugenol as a key contributor warrants further investigation into molecular mechanisms, offering hope for effectively managing chemotherapy-induced nausea and vomiting.

Makale detayları

Evaluation of anti-emetic activity of Syzygium aromaticum extracts in chick and rat models of emesis

Yazarlar: Long Chiau Ming

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.28 Issue 4, pp.1231-1243

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347038

pISSN: 2630-6344

Clove extract

antiemetic

phytochemical analysis

chick model

rat model

eugenol

Sayı

Yazarlar:

Long Chiau Ming

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 4, pp.1231-1243

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347038

pISSN:

2630-6344