Synthesis, characterization and biological activity potential of some novel thiourea derivatives

Sevda Türk; Didem Akkaya; Burak Barut

Makale detayları

Synthesis, characterization and biological activity potential of some novel thiourea derivatives

Yazarlar:

Sevda Türk | Didem Akkaya | Burak Barut

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 6, pp.1911-1920

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001334765

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Within the scope of this study, a new series of thiourea derivatives were synthesized by refluxing different anthranilic acid derivatives with various isothiocyanates in dry acetone medium. The synthesized compounds were purified by crystallization and their purity was determined by TLC method. The structures of the obtained compounds were elucidated by using different spectroscopic methods such as IR, 1H-NMR, 13C-NMR, besides elemental analysis. The inhibitory effects of the compounds against DPPH radical scavenging, α-glucosidase and acetylcholinesterase were investigated by using spectrophotometric method. The results showed that the compounds had moderate radical scavenging activity according to gallic acid 92.25  0.14 at 100 µM which was used as a reference compound. Compound 5 in the presence of trifluoromethyl group demonstrated the highest α-glucosidase inhibitory effect with 52.26  2.35 at 100 µM. On the other hand, the compounds demonstrated low AChE inhibitory effects compared to galantamine 80.33  0.77 at 100 µM which was used as a reference compound.

 Within the scope of this study, a new series of thiourea derivatives were synthesized by refluxing different anthranilic acid derivatives with various isothiocyanates in dry acetone medium. The synthesized compounds were purified by crystallization and their purity was determined by TLC method. The structures of the obtained compounds were elucidated by using different spectroscopic methods such as IR, 1H-NMR, 13C-NMR, besides elemental analysis. The inhibitory effects of the compounds against DPPH radical scavenging, α-glucosidase and acetylcholinesterase were investigated by using spectrophotometric method. The results showed that the compounds had moderate radical scavenging activity according to gallic acid 92.25  0.14 at 100 µM which was used as a reference compound. Compound 5 in the presence of trifluoromethyl group demonstrated the highest α-glucosidase inhibitory effect with 52.26  2.35 at 100 µM. On the other hand, the compounds demonstrated low AChE inhibitory effects compared to galantamine 80.33  0.77 at 100 µM which was used as a reference compound.

 Within the scope of this study, a new series of thiourea derivatives were synthesized by refluxing different anthranilic acid derivatives with various isothiocyanates in dry acetone medium. The synthesized compounds were purified by crystallization and their purity was determined by TLC method. The structures of the obtained compounds were elucidated by using different spectroscopic methods such as IR, 1H-NMR, 13C-NMR, besides elemental analysis. The inhibitory effects of the compounds against DPPH radical scavenging, α-glucosidase and acetylcholinesterase were investigated by using spectrophotometric method. The results showed that the compounds had moderate radical scavenging activity according to gallic acid 92.25  0.14 at 100 µM which was used as a reference compound. Compound 5 in the presence of trifluoromethyl group demonstrated the highest α-glucosidase inhibitory effect with 52.26  2.35 at 100 µM. On the other hand, the compounds demonstrated low AChE inhibitory effects compared to galantamine 80.33  0.77 at 100 µM which was used as a reference compound.

 Within the scope of this study, a new series of thiourea derivatives were synthesized by refluxing different anthranilic acid derivatives with various isothiocyanates in dry acetone medium. The synthesized compounds were purified by crystallization and their purity was determined by TLC method. The structures of the obtained compounds were elucidated by using different spectroscopic methods such as IR, 1H-NMR, 13C-NMR, besides elemental analysis. The inhibitory effects of the compounds against DPPH radical scavenging, α-glucosidase and acetylcholinesterase were investigated by using spectrophotometric method. The results showed that the compounds had moderate radical scavenging activity according to gallic acid 92.25  0.14 at 100 µM which was used as a reference compound. Compound 5 in the presence of trifluoromethyl group demonstrated the highest α-glucosidase inhibitory effect with 52.26  2.35 at 100 µM. On the other hand, the compounds demonstrated low AChE inhibitory effects compared to galantamine 80.33  0.77 at 100 µM which was used as a reference compound.

Makale detayları

Synthesis, characterization and biological activity potential of some novel thiourea derivatives

Yazarlar:

Sevda Türk | Didem Akkaya | Burak Barut

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 6, pp.1911-1920

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001334765

pISSN:

2630-6344

Thiourea

anthranilic acid

DPPH radical scavenging

α-glucosidase

acetylcholinesterase

Sayı

Makale detayları

Synthesis, characterization and biological activity potential of some novel thiourea derivatives

Yazarlar: Sevda Türk | Didem Akkaya | Burak Barut

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Chemistry

Dergi: Journal of Research in Pharmacy Vol.28 Issue 6, pp.1911-1920

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001334765

pISSN: 2630-6344

Thiourea

anthranilic acid

DPPH radical scavenging

α-glucosidase

acetylcholinesterase

Sayı

Yazarlar:

Sevda Türk | Didem Akkaya | Burak Barut

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 6, pp.1911-1920

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001334765

pISSN:

2630-6344