Investigation of Chloride Anion Binding Properties of Glipizide Drug

Serap Mert

Makale detayları

Investigation of Chloride Anion Binding Properties of Glipizide Drug

Yazarlar:

Serap Mert

Yayıncı:

Gazi University

Ana Başlıklar:

Organic Chemistry (Other)

Dergi:

Gazi University Journal of Science Part A: Engineering and Innovation Vol.10 Issue 3, pp.262-277

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001299907

pISSN:

2147-9542

Anahtar kelimeler:

Özet:

 This study addresses the anion binding property of Glipizide GLP, an oral antidiabetic a second-generation drug member of the sulphonylurea SU family. GLP effectively interacts with Cl- anion according to 1H-NMR spectroscopic titrations of successive tetrabutylammonium chloride TBACl in deuterated chloroform CDCl3 and dimethyl sulfoxide d6-DMSO. Upon the addition of TBACl, the change in chemical shift was observed for both N-H protons of SU in CDCl3, whereas it causes a difference in the shift of only one of N-H proton in SU in d6-DMSO. In addition, the data obtained from 1H-NMR spectroscopic titrations was analyzed by DynaFit program to calculate the binding constant Ka value between GLP and Cl- anion. It was found that GLP binds Cl- anion in CDCl3 with higher affinity Ka77.37 M-1, Fitplot for N-Hh proton at δ6.47 ppm than in d6-DMSO Ka38.53 M-1, Fitplot for N-Hh proton at δ6.32 ppm.

 This study addresses the anion binding property of Glipizide GLP, an oral antidiabetic a second-generation drug member of the sulphonylurea SU family. GLP effectively interacts with Cl- anion according to 1H-NMR spectroscopic titrations of successive tetrabutylammonium chloride TBACl in deuterated chloroform CDCl3 and dimethyl sulfoxide d6-DMSO. Upon the addition of TBACl, the change in chemical shift was observed for both N-H protons of SU in CDCl3, whereas it causes a difference in the shift of only one of N-H proton in SU in d6-DMSO. In addition, the data obtained from 1H-NMR spectroscopic titrations was analyzed by DynaFit program to calculate the binding constant Ka value between GLP and Cl- anion. It was found that GLP binds Cl- anion in CDCl3 with higher affinity Ka77.37 M-1, Fitplot for N-Hh proton at δ6.47 ppm than in d6-DMSO Ka38.53 M-1, Fitplot for N-Hh proton at δ6.32 ppm.

 This study addresses the anion binding property of Glipizide GLP, an oral antidiabetic a second-generation drug member of the sulphonylurea SU family. GLP effectively interacts with Cl- anion according to 1H-NMR spectroscopic titrations of successive tetrabutylammonium chloride TBACl in deuterated chloroform CDCl3 and dimethyl sulfoxide d6-DMSO. Upon the addition of TBACl, the change in chemical shift was observed for both N-H protons of SU in CDCl3, whereas it causes a difference in the shift of only one of N-H proton in SU in d6-DMSO. In addition, the data obtained from 1H-NMR spectroscopic titrations was analyzed by DynaFit program to calculate the binding constant Ka value between GLP and Cl- anion. It was found that GLP binds Cl- anion in CDCl3 with higher affinity Ka77.37 M-1, Fitplot for N-Hh proton at δ6.47 ppm than in d6-DMSO Ka38.53 M-1, Fitplot for N-Hh proton at δ6.32 ppm.

 This study addresses the anion binding property of Glipizide GLP, an oral antidiabetic a second-generation drug member of the sulphonylurea SU family. GLP effectively interacts with Cl- anion according to 1H-NMR spectroscopic titrations of successive tetrabutylammonium chloride TBACl in deuterated chloroform CDCl3 and dimethyl sulfoxide d6-DMSO. Upon the addition of TBACl, the change in chemical shift was observed for both N-H protons of SU in CDCl3, whereas it causes a difference in the shift of only one of N-H proton in SU in d6-DMSO. In addition, the data obtained from 1H-NMR spectroscopic titrations was analyzed by DynaFit program to calculate the binding constant Ka value between GLP and Cl- anion. It was found that GLP binds Cl- anion in CDCl3 with higher affinity Ka77.37 M-1, Fitplot for N-Hh proton at δ6.47 ppm than in d6-DMSO Ka38.53 M-1, Fitplot for N-Hh proton at δ6.32 ppm.

Makale detayları

Investigation of Chloride Anion Binding Properties of Glipizide Drug

Yazarlar:

Serap Mert

Yayıncı:

Gazi University

Ana Başlıklar:

Organic Chemistry (Other)

Dergi:

Gazi University Journal of Science Part A: Engineering and Innovation Vol.10 Issue 3, pp.262-277

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001299907

pISSN:

2147-9542

Anion Receptor

Sulphonylurea

Glipizide

1H-NMR Titration

Sayı

Makale detayları

Investigation of Chloride Anion Binding Properties of Glipizide Drug

Yazarlar: Serap Mert

Yayıncı: Gazi University

Ana Başlıklar: Organic Chemistry (Other)

Dergi: Gazi University Journal of Science Part A: Engineering and Innovation Vol.10 Issue 3, pp.262-277

Belge Tipi: Makale

Yayın Tarihi: 9/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001299907

pISSN: 2147-9542

Anion Receptor

Sulphonylurea

Glipizide

1H-NMR Titration

Sayı

Yazarlar:

Serap Mert

Yayıncı:

Gazi University

Ana Başlıklar:

Organic Chemistry (Other)

Dergi:

Gazi University Journal of Science Part A: Engineering and Innovation Vol.10 Issue 3, pp.262-277

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001299907

pISSN:

2147-9542