Cystatin C as biomarker of contrast-induced nephropathy in pediatric cardiac angiography

Osman ÖZDEMİR; Ayşe Deniz OĞUZ; Abdülkadir EREN

Makale detayları

Cystatin C as biomarker of contrast-induced nephropathy in pediatric cardiac angiography

Yazarlar:

Osman ÖZDEMİR | Ayşe Deniz OĞUZ | Abdülkadir EREN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 2, pp.178-185

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000753295

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

The purpose of this study is to find the frequency of contrast-induced nephropathy (CIN) and to show the risk factors in the development of CIN and the diagnostic utility of serum cystatin C (CysC) and serum and urine neutrophil gelatinase-associated lipocalin (NGAL) during childhood following cardiac angiography.  Materials and methods: In this prospective study, we studied 46 children with congenital heart disease. The levels of serum creatinine, serum CysC, and serum NGAL were measured at 4, 24, and 48 h, while levels of urine NGAL and urine creatinine were measured at 4 to 8 and 48 h following cardiac angiography.  Results: According to serum creatinine levels, with a cutoff value of 4.1 mL/kg for development of CIN, sensitivity, specificity, area under the receiver-operating characteristic curve, and positive likelihood ratio were calculated as 69%, 70%, 0.67, and 2.29, respectively. The levels of serum CysC and serum creatinine significantly increased at 4, 24, and 48 h after the application of the contrast agent.   Conclusion: The results of this study show that according to the definition of CIN, the incidence of CIN is significantly increased in pediatric patients with congenital heart disease. Moreover, the results support that serum CysC levels may allow the detection of CIN after cardiac angiography, like serum creatinine in present study.

 

The purpose of this study is to find the frequency of contrast-induced nephropathy (CIN) and to show the risk factors in the development of CIN and the diagnostic utility of serum cystatin C (CysC) and serum and urine neutrophil gelatinase-associated lipocalin (NGAL) during childhood following cardiac angiography.  Materials and methods: In this prospective study, we studied 46 children with congenital heart disease. The levels of serum creatinine, serum CysC, and serum NGAL were measured at 4, 24, and 48 h, while levels of urine NGAL and urine creatinine were measured at 4 to 8 and 48 h following cardiac angiography.  Results: According to serum creatinine levels, with a cutoff value of 4.1 mL/kg for development of CIN, sensitivity, specificity, area under the receiver-operating characteristic curve, and positive likelihood ratio were calculated as 69%, 70%, 0.67, and 2.29, respectively. The levels of serum CysC and serum creatinine significantly increased at 4, 24, and 48 h after the application of the contrast agent.   Conclusion: The results of this study show that according to the definition of CIN, the incidence of CIN is significantly increased in pediatric patients with congenital heart disease. Moreover, the results support that serum CysC levels may allow the detection of CIN after cardiac angiography, like serum creatinine in present study.

Makale detayları

Cystatin C as biomarker of contrast-induced nephropathy in pediatric cardiac angiography

Yazarlar:

Osman ÖZDEMİR | Ayşe Deniz OĞUZ | Abdülkadir EREN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 2, pp.178-185

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000753295

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Cardiac angiography

contrast media

creatinine

cystatin C

lipocalin

nephropathy

Sayı

Makale detayları

Cystatin C as biomarker of contrast-induced nephropathy in pediatric cardiac angiography

Yazarlar: Osman ÖZDEMİR | Ayşe Deniz OĞUZ | Abdülkadir EREN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2014 Vol.44 Issue 2, pp.178-185

Belge Tipi: Makale

Yayın Tarihi: 5/2014

Belge Dili: Türkçe

Document ID (Org No.): 2000753295

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Cardiac angiography

contrast media

creatinine

cystatin C

lipocalin

nephropathy

Sayı

Yazarlar:

Osman ÖZDEMİR | Ayşe Deniz OĞUZ | Abdülkadir EREN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 2, pp.178-185

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000753295

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144