Formulation and in-vitro evaluation of emulsion loaded topical gel for the enhancement of diffusion through the skin for the treatment of skin irritation

N.A.

Makale detayları

Formulation and in-vitro evaluation of emulsion loaded topical gel for the enhancement of diffusion through the skin for the treatment of skin irritation

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 5, pp.1112-1124

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347534

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The purpose of the current study is to formulate and develop an emulsion gel oil-in -water which removes all obstacles related to its diffusion, stability and irritation of ascorbic acid. Pursued this study with preformulation and determined melting point 190.30.577, solubility, preferably soluble in water and 7.4 Phosphate buffer solution. Drug identification studies were performed by UV spectrophotometer and FTIR. The ʎmax of ascorbic was found at 260nm while during FTIR studies, all important peaks were observed, showed the authenticity of the drug. Drug and the excipient were found compatible. Nine formulations of emulsion were formulated by the dispersion method and they were evaluated for particle size diameter 138.71 nm, zeta potential -37.2mV, optical microscopy, drug content 99.2110.202 which was found with in limit, of drug was, the globule size discovered by TEM and observed spherical in shape. Among all nine formulations, F5 showed its best results and it was used for further emulsion gel preparation. The Carbopol 934 p polymer was used with varies concentration from 0.5 to 2 for gel preparation and it was added into F5 formulation and noted that, while 1 polymer concentration was used, it has given the best release 99.7780.073 in 6 hours, stability and viscosity.

 The purpose of the current study is to formulate and develop an emulsion gel oil-in -water which removes all obstacles related to its diffusion, stability and irritation of ascorbic acid. Pursued this study with preformulation and determined melting point 190.30.577, solubility, preferably soluble in water and 7.4 Phosphate buffer solution. Drug identification studies were performed by UV spectrophotometer and FTIR. The ʎmax of ascorbic was found at 260nm while during FTIR studies, all important peaks were observed, showed the authenticity of the drug. Drug and the excipient were found compatible. Nine formulations of emulsion were formulated by the dispersion method and they were evaluated for particle size diameter 138.71 nm, zeta potential -37.2mV, optical microscopy, drug content 99.2110.202 which was found with in limit, of drug was, the globule size discovered by TEM and observed spherical in shape. Among all nine formulations, F5 showed its best results and it was used for further emulsion gel preparation. The Carbopol 934 p polymer was used with varies concentration from 0.5 to 2 for gel preparation and it was added into F5 formulation and noted that, while 1 polymer concentration was used, it has given the best release 99.7780.073 in 6 hours, stability and viscosity.

 The purpose of the current study is to formulate and develop an emulsion gel oil-in -water which removes all obstacles related to its diffusion, stability and irritation of ascorbic acid. Pursued this study with preformulation and determined melting point 190.30.577, solubility, preferably soluble in water and 7.4 Phosphate buffer solution. Drug identification studies were performed by UV spectrophotometer and FTIR. The ʎmax of ascorbic was found at 260nm while during FTIR studies, all important peaks were observed, showed the authenticity of the drug. Drug and the excipient were found compatible. Nine formulations of emulsion were formulated by the dispersion method and they were evaluated for particle size diameter 138.71 nm, zeta potential -37.2mV, optical microscopy, drug content 99.2110.202 which was found with in limit, of drug was, the globule size discovered by TEM and observed spherical in shape. Among all nine formulations, F5 showed its best results and it was used for further emulsion gel preparation. The Carbopol 934 p polymer was used with varies concentration from 0.5 to 2 for gel preparation and it was added into F5 formulation and noted that, while 1 polymer concentration was used, it has given the best release 99.7780.073 in 6 hours, stability and viscosity.

 The purpose of the current study is to formulate and develop an emulsion gel oil-in -water which removes all obstacles related to its diffusion, stability and irritation of ascorbic acid. Pursued this study with preformulation and determined melting point 190.30.577, solubility, preferably soluble in water and 7.4 Phosphate buffer solution. Drug identification studies were performed by UV spectrophotometer and FTIR. The ʎmax of ascorbic was found at 260nm while during FTIR studies, all important peaks were observed, showed the authenticity of the drug. Drug and the excipient were found compatible. Nine formulations of emulsion were formulated by the dispersion method and they were evaluated for particle size diameter 138.71 nm, zeta potential -37.2mV, optical microscopy, drug content 99.2110.202 which was found with in limit, of drug was, the globule size discovered by TEM and observed spherical in shape. Among all nine formulations, F5 showed its best results and it was used for further emulsion gel preparation. The Carbopol 934 p polymer was used with varies concentration from 0.5 to 2 for gel preparation and it was added into F5 formulation and noted that, while 1 polymer concentration was used, it has given the best release 99.7780.073 in 6 hours, stability and viscosity.

Makale detayları

Formulation and in-vitro evaluation of emulsion loaded topical gel for the enhancement of diffusion through the skin for the treatment of skin irritation

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 5, pp.1112-1124

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347534

pISSN:

2630-6344

Emulsion gel

stability

skin irritation

FTIR

TEM studies

drug release

Sayı

Makale detayları

Formulation and in-vitro evaluation of emulsion loaded topical gel for the enhancement of diffusion through the skin for the treatment of skin irritation

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Sciences

Dergi: Journal of Research in Pharmacy Vol.26 Issue 5, pp.1112-1124

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347534

pISSN: 2630-6344

Emulsion gel

stability

skin irritation

FTIR

TEM studies

drug release

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Sciences

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 5, pp.1112-1124

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347534

pISSN:

2630-6344