Anti-nephrolithiatic efficacy of Teucrium polium aerial parts extract in a lithiasic rat model

N.A.

Makale detayları

Anti-nephrolithiatic efficacy of Teucrium polium aerial parts extract in a lithiasic rat model

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 6, pp.874-881

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348011

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The present study was designed to investigate the anti-nephrolithiatic potential of the aqueous extract of Teucrium polium in male Wistar rats. The experiment was carried out in male rats divided into 4 groups, each of which contain 6 animals. Group I normal control received distilled water for 40 days. Group IInephrolithiatic control to IVtreatment groupsanimals received 1 vv ethylene glycol EG in distilled water for 20 days. Group III standard group received Cystone 750 mgkg from 20th day - 40th day. Group IV received 200mgkg from 20th to 40th day. Urinary volume, pH, and biochemical parameters such as calcium, uric acid, urea, phosphorus and oxalate; and serum calcium, blood urea nitrogenBUN, uric acid, phosphorus, creatinine and magnesium were assessed. In addition, histopathological changes in kidney were carried out. Supplementation with aqueous extract of T. polium significantly increased urine volume P0.01 and urine pH P0.05. Aqueous extract of T. polium significantly reduced the elevated urinary and serum levels of uric acid P0.001. Moreover, it significantly lowered the urinary, serum levels of phosphorusP0.05 and significantly improved serum magnesium levelP0.05. It is noteworthy to mention that T. polium revealed no effect on the other biochemical parameters. We can conclude that T. polium aqueous extract could decrease the risk of formation of CaOx stones by affecting many biochemical parameters other than oxalate.

 The present study was designed to investigate the anti-nephrolithiatic potential of the aqueous extract of Teucrium polium in male Wistar rats. The experiment was carried out in male rats divided into 4 groups, each of which contain 6 animals. Group I normal control received distilled water for 40 days. Group IInephrolithiatic control to IVtreatment groupsanimals received 1 vv ethylene glycol EG in distilled water for 20 days. Group III standard group received Cystone 750 mgkg from 20th day - 40th day. Group IV received 200mgkg from 20th to 40th day. Urinary volume, pH, and biochemical parameters such as calcium, uric acid, urea, phosphorus and oxalate; and serum calcium, blood urea nitrogenBUN, uric acid, phosphorus, creatinine and magnesium were assessed. In addition, histopathological changes in kidney were carried out. Supplementation with aqueous extract of T. polium significantly increased urine volume P0.01 and urine pH P0.05. Aqueous extract of T. polium significantly reduced the elevated urinary and serum levels of uric acid P0.001. Moreover, it significantly lowered the urinary, serum levels of phosphorusP0.05 and significantly improved serum magnesium levelP0.05. It is noteworthy to mention that T. polium revealed no effect on the other biochemical parameters. We can conclude that T. polium aqueous extract could decrease the risk of formation of CaOx stones by affecting many biochemical parameters other than oxalate.

 The present study was designed to investigate the anti-nephrolithiatic potential of the aqueous extract of Teucrium polium in male Wistar rats. The experiment was carried out in male rats divided into 4 groups, each of which contain 6 animals. Group I normal control received distilled water for 40 days. Group IInephrolithiatic control to IVtreatment groupsanimals received 1 vv ethylene glycol EG in distilled water for 20 days. Group III standard group received Cystone 750 mgkg from 20th day - 40th day. Group IV received 200mgkg from 20th to 40th day. Urinary volume, pH, and biochemical parameters such as calcium, uric acid, urea, phosphorus and oxalate; and serum calcium, blood urea nitrogenBUN, uric acid, phosphorus, creatinine and magnesium were assessed. In addition, histopathological changes in kidney were carried out. Supplementation with aqueous extract of T. polium significantly increased urine volume P0.01 and urine pH P0.05. Aqueous extract of T. polium significantly reduced the elevated urinary and serum levels of uric acid P0.001. Moreover, it significantly lowered the urinary, serum levels of phosphorusP0.05 and significantly improved serum magnesium levelP0.05. It is noteworthy to mention that T. polium revealed no effect on the other biochemical parameters. We can conclude that T. polium aqueous extract could decrease the risk of formation of CaOx stones by affecting many biochemical parameters other than oxalate.

 The present study was designed to investigate the anti-nephrolithiatic potential of the aqueous extract of Teucrium polium in male Wistar rats. The experiment was carried out in male rats divided into 4 groups, each of which contain 6 animals. Group I normal control received distilled water for 40 days. Group IInephrolithiatic control to IVtreatment groupsanimals received 1 vv ethylene glycol EG in distilled water for 20 days. Group III standard group received Cystone 750 mgkg from 20th day - 40th day. Group IV received 200mgkg from 20th to 40th day. Urinary volume, pH, and biochemical parameters such as calcium, uric acid, urea, phosphorus and oxalate; and serum calcium, blood urea nitrogenBUN, uric acid, phosphorus, creatinine and magnesium were assessed. In addition, histopathological changes in kidney were carried out. Supplementation with aqueous extract of T. polium significantly increased urine volume P0.01 and urine pH P0.05. Aqueous extract of T. polium significantly reduced the elevated urinary and serum levels of uric acid P0.001. Moreover, it significantly lowered the urinary, serum levels of phosphorusP0.05 and significantly improved serum magnesium levelP0.05. It is noteworthy to mention that T. polium revealed no effect on the other biochemical parameters. We can conclude that T. polium aqueous extract could decrease the risk of formation of CaOx stones by affecting many biochemical parameters other than oxalate.

Makale detayları

Anti-nephrolithiatic efficacy of Teucrium polium aerial parts extract in a lithiasic rat model

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 6, pp.874-881

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348011

pISSN:

2630-6344

Nephrolithiasis

kidney stone

calcium oxalate (CaOx)

Teucrium polium

thylene glycol

Sayı

Makale detayları

Anti-nephrolithiatic efficacy of Teucrium polium aerial parts extract in a lithiasic rat model

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.24 Issue 6, pp.874-881

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001348011

pISSN: 2630-6344

Nephrolithiasis

kidney stone

calcium oxalate (CaOx)

Teucrium polium

thylene glycol

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 6, pp.874-881

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348011

pISSN:

2630-6344