NF-?? and SOD expression in preeclamptic placentas

Abraham Silva CARMONA; Hugo Mendieta ZERON

Makale detayları

NF-?? and SOD expression in preeclamptic placentas

Yazarlar:

Abraham Silva CARMONA | Hugo Mendieta ZERON

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 3, pp.783-788

Belge Tipi:

Makale

Yayın Tarihi:

5/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000752087

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: Preeclampsia is a leading cause of maternal death in the developing world. Our aim was to quantify and compare messenger (mRNA) expression of nuclear factor-kappa beta (NF-?β) and superoxide dismutase (SOD) in control patients with preeclampsia and without preeclampsia with or without familial hereditary background.   Materials and methods: Four groups of patients were formed depending on the presence or absence of preeclampsia and presence or absence of familial history for preeclampsia. NF-?β and SOD were measured in human placentas by real-time quantitative polymerase chain reaction. The 2-ΔΔct analysis method was used to measure the difference in the relative expression of the target genes in each group of patients.   Results: In NF-?β expression, there was an increase of 23.35% in the group of women with preeclampsia versus women with preeclampsia without familial history. Regarding SOD, there was a reduction of about 33.33% in the expression in women with preeclampsia with familial history versus women with preeclampsia without familial history.   Conclusion: Familial presence of preeclampsia could predispose to altered expression in SOD and NF-?β.

Makale detayları

NF-?? and SOD expression in preeclamptic placentas

Yazarlar: Abraham Silva CARMONA | Hugo Mendieta ZERON

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2016 Vol.46 Issue 3, pp.783-788

Belge Tipi: Makale

Yayın Tarihi: 5/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000752087

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Abraham Silva CARMONA | Hugo Mendieta ZERON

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 3, pp.783-788

Belge Tipi:

Makale

Yayın Tarihi:

5/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000752087

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144