Effects of Pervari Honey from Türkiye on Proliferation, Oxidative Stress, and Apoptosis of Human Breast Cancer Cells

Muazzez Derya Andeden; Pınar Altın Çelik; Mustafa Çakır; Ramazan Üzen; Hamiyet Altuntaş

Makale detayları

Effects of Pervari Honey from Türkiye on Proliferation, Oxidative Stress, and Apoptosis of Human Breast Cancer Cells

Yazarlar:

Muazzez Derya Andeden | Pınar Altın Çelik | Mustafa Çakır | Ramazan Üzen | Hamiyet Altuntaş

Yayıncı:

Çanakkale Onsekiz Mart University

Ana Başlıklar:

Cell Development | Proliferation and Death | Cancer Biology

Dergi:

Journal of Advanced Research in Natural and Applied Sciences Vol.10 Issue 3, pp.627-639

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001328945

pISSN:

2757-5195

Anahtar kelimeler:

Özet:

 Breast cancer is one of the most common causes of deaths worldwide. Major obstacles to treatment have contributed to the increasing popularity of complementary or alternative therapies. Although recent results support the mechanism that honey induces cell death, the full mechanisms are still unknown. This study investigates the potential use of Pervari honey PH as an in vitro therapeutic agent in breast cancer. Firstly, the antioxidant capacity and total phenolic content of PH were tested. In addition, MCF-7 and MDA-MB-231 breast cancer cells treated with PH were examined for cell viability, reactive oxygen species production, oxidative deoxyribonucleic acid DNA damage, and apoptosis. Our results show that PH treatment decreased cell viability dose-dependently and increased reactive oxygen species ROS levels, oxidative DNA damage, and apoptosis rate. The present study suggests that honey is a promising source to produce pharmaceuticals and nutraceuticals for breast cancer therapy.

 Breast cancer is one of the most common causes of deaths worldwide. Major obstacles to treatment have contributed to the increasing popularity of complementary or alternative therapies. Although recent results support the mechanism that honey induces cell death, the full mechanisms are still unknown. This study investigates the potential use of Pervari honey PH as an in vitro therapeutic agent in breast cancer. Firstly, the antioxidant capacity and total phenolic content of PH were tested. In addition, MCF-7 and MDA-MB-231 breast cancer cells treated with PH were examined for cell viability, reactive oxygen species production, oxidative deoxyribonucleic acid DNA damage, and apoptosis. Our results show that PH treatment decreased cell viability dose-dependently and increased reactive oxygen species ROS levels, oxidative DNA damage, and apoptosis rate. The present study suggests that honey is a promising source to produce pharmaceuticals and nutraceuticals for breast cancer therapy.

 Breast cancer is one of the most common causes of deaths worldwide. Major obstacles to treatment have contributed to the increasing popularity of complementary or alternative therapies. Although recent results support the mechanism that honey induces cell death, the full mechanisms are still unknown. This study investigates the potential use of Pervari honey PH as an in vitro therapeutic agent in breast cancer. Firstly, the antioxidant capacity and total phenolic content of PH were tested. In addition, MCF-7 and MDA-MB-231 breast cancer cells treated with PH were examined for cell viability, reactive oxygen species production, oxidative deoxyribonucleic acid DNA damage, and apoptosis. Our results show that PH treatment decreased cell viability dose-dependently and increased reactive oxygen species ROS levels, oxidative DNA damage, and apoptosis rate. The present study suggests that honey is a promising source to produce pharmaceuticals and nutraceuticals for breast cancer therapy.

 Breast cancer is one of the most common causes of deaths worldwide. Major obstacles to treatment have contributed to the increasing popularity of complementary or alternative therapies. Although recent results support the mechanism that honey induces cell death, the full mechanisms are still unknown. This study investigates the potential use of Pervari honey PH as an in vitro therapeutic agent in breast cancer. Firstly, the antioxidant capacity and total phenolic content of PH were tested. In addition, MCF-7 and MDA-MB-231 breast cancer cells treated with PH were examined for cell viability, reactive oxygen species production, oxidative deoxyribonucleic acid DNA damage, and apoptosis. Our results show that PH treatment decreased cell viability dose-dependently and increased reactive oxygen species ROS levels, oxidative DNA damage, and apoptosis rate. The present study suggests that honey is a promising source to produce pharmaceuticals and nutraceuticals for breast cancer therapy.

Makale detayları

Effects of Pervari Honey from Türkiye on Proliferation, Oxidative Stress, and Apoptosis of Human Breast Cancer Cells

Yazarlar:

Muazzez Derya Andeden | Pınar Altın Çelik | Mustafa Çakır | Ramazan Üzen | Hamiyet Altuntaş

Yayıncı:

Çanakkale Onsekiz Mart University

Ana Başlıklar:

Cell Development | Proliferation and Death | Cancer Biology

Dergi:

Journal of Advanced Research in Natural and Applied Sciences Vol.10 Issue 3, pp.627-639

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001328945

pISSN:

2757-5195

Antioxidant

apoptosis

cancer

honey

oxidative deoxyribonucleic acid (DNA) damage

reactive oxygen species

Sayı

Makale detayları

Effects of Pervari Honey from Türkiye on Proliferation, Oxidative Stress, and Apoptosis of Human Breast Cancer Cells

Yazarlar: Muazzez Derya Andeden | Pınar Altın Çelik | Mustafa Çakır | Ramazan Üzen | Hamiyet Altuntaş

Yayıncı: Çanakkale Onsekiz Mart University

Ana Başlıklar: Cell Development | Proliferation and Death | Cancer Biology

Dergi: Journal of Advanced Research in Natural and Applied Sciences Vol.10 Issue 3, pp.627-639

Belge Tipi: Makale

Yayın Tarihi: 9/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001328945

pISSN: 2757-5195

Antioxidant

apoptosis

cancer

honey

oxidative deoxyribonucleic acid (DNA) damage

reactive oxygen species

Sayı

Yazarlar:

Muazzez Derya Andeden | Pınar Altın Çelik | Mustafa Çakır | Ramazan Üzen | Hamiyet Altuntaş

Yayıncı:

Çanakkale Onsekiz Mart University

Ana Başlıklar:

Cell Development | Proliferation and Death | Cancer Biology

Dergi:

Journal of Advanced Research in Natural and Applied Sciences Vol.10 Issue 3, pp.627-639

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001328945

pISSN:

2757-5195