pH-RESPONSIVE CARBOXYMETHYL CELLULOSE CONJUGATED SUPERPARAMAGNETIC IRON OXIDE NANOCARRIERS

Tülin GÜRKAN POLAT; Seda DEMİREL TOPEL

doi:https://doi.org/10.26900/jsp.3.011

Makale detayları

pH-RESPONSIVE CARBOXYMETHYL CELLULOSE CONJUGATED SUPERPARAMAGNETIC IRON OXIDE NANOCARRIERS

Yazarlar:

Tülin GÜRKAN POLAT | Seda DEMİREL TOPEL

Yayıncı:

Rating Academy

Ana Başlıklar:

Astronomi ve ilgili bilimler

Dergi:

Journal of Scientific Perspectives 2019 Vol.3 Issue 2, pp.99-110

Belge Tipi:

Makale

Yayın Tarihi:

4/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000743921

Sıklık:

Aylık

eISSN:

2791-6022

DOI:

https://doi.org/10.26900/jsp.3.011

Özet:

 


In the present study, polyethyleneimine (PEI) coated
superparamagnetic iron oxide nanoparticles (SPIONs) having the size of 15 nm in
diameter with high magnetic saturation (60 emu/g) have been prepared by
co-precipitation method. The synthesized PEI-Fe3O4 nanoparticles have been
fully characterized by transmission electron microscope (TEM), dynamic light
scattering (DLS), Fourier transform infrared (FTIR) spectroscopy, X-ray
photoelectron spectroscopy (XPS) and X-ray diffraction (XRD) techniques. The
free amine groups on the PEI-Fe3O4 surface has been covalently functionalized
with carboxymethyl cellulose (CMC) by the catalysis of
N,N'-Dicyclohexylcarbodiimide (DCC) and N, N'-Dimethylpyridin-4-amine (DMAP)
coupling to produce CMC-Fe3O4 nanocarriers. The prepared CMC-Fe3O4 nanocarriers
have been loaded with a well-known anti-tumor drug doxorubicin (Dox) and
investigated its loading and releasing profiles from the nanocarrier. The CMC
acted as an excellent nanocarrier for Dox with a loading efficiency ≈ 86%. The
drug releasing profile has been studied at different pH values (3.5; 5.5; and
7.4). When the pH of the release medium (phosphate buffer solution) was changed
from 7.4 to 5.5 or 3.6, the drug release has been increased which indicates
that the drug releasing is pH dependent.


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Makale detayları

pH-RESPONSIVE CARBOXYMETHYL CELLULOSE CONJUGATED SUPERPARAMAGNETIC IRON OXIDE NANOCARRIERS

Yazarlar: Tülin GÜRKAN POLAT | Seda DEMİREL TOPEL

Yayıncı: Rating Academy

Ana Başlıklar: Astronomi ve ilgili bilimler

Dergi: Journal of Scientific Perspectives 2019 Vol.3 Issue 2, pp.99-110

Belge Tipi: Makale

Yayın Tarihi: 4/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000743921

Sıklık: Aylık

eISSN: 2791-6022

DOI: https://doi.org/10.26900/jsp.3.011

Sayı

Yazarlar:

Tülin GÜRKAN POLAT | Seda DEMİREL TOPEL

Yayıncı:

Rating Academy

Ana Başlıklar:

Astronomi ve ilgili bilimler

Dergi:

Journal of Scientific Perspectives 2019 Vol.3 Issue 2, pp.99-110

Belge Tipi:

Makale

Yayın Tarihi:

4/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000743921

Sıklık:

Aylık

eISSN:

2791-6022

DOI:

https://doi.org/10.26900/jsp.3.011