Desflurane Protects The Brain Against The Oxidant Activity of Acute Hyperglycemia in Diabetic Rats, Comparison with Sevoflurane

Alican Kaya; Mustafa Arslan; Elif Beşkardeş; Ömer Kurtipek; Dilek Kalaycı; Alper Tunga Dogan; Ayşe Hande Arpacı; Işın Güneş; Mustafa Kavutcu

Makale detayları

Desflurane Protects The Brain Against The Oxidant Activity of Acute Hyperglycemia in Diabetic Rats, Comparison with Sevoflurane

Yazarlar:

Alican Kaya | Mustafa Arslan | Elif Beşkardeş | Ömer Kurtipek | Dilek Kalaycı | Alper Tunga Dogan | Ayşe Hande Arpacı | Işın Güneş | Mustafa Kavutcu

Yayıncı:

Gazi University

Ana Başlıklar:

Primary Health Care

Dergi:

Journal of Gazi University Health Sciences Institute Vol.5 Issue 1, pp.34-41

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001288537

pISSN:

2687-6353

Anahtar kelimeler:

Özet:

 In this study, we investigated the effects of sevoflurane and desflurane administration on the oxidant and antioxidant system in the brain of acute hyperglycemia in diabetic rats. In the study, 30 male Wistar Albino rats were randomly divided into five groups. Diabetes was induced by administering a single dose of intraperitoneal streptozotocin 55 mgkg to rats except for the control group C. To create acute hyperglycemia in diabetic groups, which were hyperglycemia DH, desflurane D, and sevoflurane S groups, 2.5 gkg glucose was administered intraperitoneally. After glucose administration, desflurane 6 and sevoflurane 2.3 mixed with 4 Lmin oxygen were administered for 2 hours, by which minimal alveolar concentration for rats would be one. Afterward, the animals were sacrificed, and their brain tissues were prepared for biochemical analysis. Catalase CAT, glutathione-s-transferase GST, paraoxonase PON activities, and TBARS levels were measured to determine oxidant and antioxidant status. GST activity was significantly lower in group D than in group DH p0.001. The PON activity was significantly lower in the D group compared with other groups p0.001. In the S group, PON activity was significantly lower than in the diabetic control DC group and DH groups p0.022, p0.020, respectively. TBARS level was significantly lower in group D than in group DH p0.013. As a result, desflurane decreases GST and PON activity and TBARS levels more than sevoflurane. In terms of lipid peroxidation, desflurane shows more protective properties than sevoflurane. Since our study is the first study in this field, it should be supported by other studies to be carried out.

 In this study, we investigated the effects of sevoflurane and desflurane administration on the oxidant and antioxidant system in the brain of acute hyperglycemia in diabetic rats. In the study, 30 male Wistar Albino rats were randomly divided into five groups. Diabetes was induced by administering a single dose of intraperitoneal streptozotocin 55 mgkg to rats except for the control group C. To create acute hyperglycemia in diabetic groups, which were hyperglycemia DH, desflurane D, and sevoflurane S groups, 2.5 gkg glucose was administered intraperitoneally. After glucose administration, desflurane 6 and sevoflurane 2.3 mixed with 4 Lmin oxygen were administered for 2 hours, by which minimal alveolar concentration for rats would be one. Afterward, the animals were sacrificed, and their brain tissues were prepared for biochemical analysis. Catalase CAT, glutathione-s-transferase GST, paraoxonase PON activities, and TBARS levels were measured to determine oxidant and antioxidant status. GST activity was significantly lower in group D than in group DH p0.001. The PON activity was significantly lower in the D group compared with other groups p0.001. In the S group, PON activity was significantly lower than in the diabetic control DC group and DH groups p0.022, p0.020, respectively. TBARS level was significantly lower in group D than in group DH p0.013. As a result, desflurane decreases GST and PON activity and TBARS levels more than sevoflurane. In terms of lipid peroxidation, desflurane shows more protective properties than sevoflurane. Since our study is the first study in this field, it should be supported by other studies to be carried out.

 In this study, we investigated the effects of sevoflurane and desflurane administration on the oxidant and antioxidant system in the brain of acute hyperglycemia in diabetic rats. In the study, 30 male Wistar Albino rats were randomly divided into five groups. Diabetes was induced by administering a single dose of intraperitoneal streptozotocin 55 mgkg to rats except for the control group C. To create acute hyperglycemia in diabetic groups, which were hyperglycemia DH, desflurane D, and sevoflurane S groups, 2.5 gkg glucose was administered intraperitoneally. After glucose administration, desflurane 6 and sevoflurane 2.3 mixed with 4 Lmin oxygen were administered for 2 hours, by which minimal alveolar concentration for rats would be one. Afterward, the animals were sacrificed, and their brain tissues were prepared for biochemical analysis. Catalase CAT, glutathione-s-transferase GST, paraoxonase PON activities, and TBARS levels were measured to determine oxidant and antioxidant status. GST activity was significantly lower in group D than in group DH p0.001. The PON activity was significantly lower in the D group compared with other groups p0.001. In the S group, PON activity was significantly lower than in the diabetic control DC group and DH groups p0.022, p0.020, respectively. TBARS level was significantly lower in group D than in group DH p0.013. As a result, desflurane decreases GST and PON activity and TBARS levels more than sevoflurane. In terms of lipid peroxidation, desflurane shows more protective properties than sevoflurane. Since our study is the first study in this field, it should be supported by other studies to be carried out.

 In this study, we investigated the effects of sevoflurane and desflurane administration on the oxidant and antioxidant system in the brain of acute hyperglycemia in diabetic rats. In the study, 30 male Wistar Albino rats were randomly divided into five groups. Diabetes was induced by administering a single dose of intraperitoneal streptozotocin 55 mgkg to rats except for the control group C. To create acute hyperglycemia in diabetic groups, which were hyperglycemia DH, desflurane D, and sevoflurane S groups, 2.5 gkg glucose was administered intraperitoneally. After glucose administration, desflurane 6 and sevoflurane 2.3 mixed with 4 Lmin oxygen were administered for 2 hours, by which minimal alveolar concentration for rats would be one. Afterward, the animals were sacrificed, and their brain tissues were prepared for biochemical analysis. Catalase CAT, glutathione-s-transferase GST, paraoxonase PON activities, and TBARS levels were measured to determine oxidant and antioxidant status. GST activity was significantly lower in group D than in group DH p0.001. The PON activity was significantly lower in the D group compared with other groups p0.001. In the S group, PON activity was significantly lower than in the diabetic control DC group and DH groups p0.022, p0.020, respectively. TBARS level was significantly lower in group D than in group DH p0.013. As a result, desflurane decreases GST and PON activity and TBARS levels more than sevoflurane. In terms of lipid peroxidation, desflurane shows more protective properties than sevoflurane. Since our study is the first study in this field, it should be supported by other studies to be carried out.

Makale detayları

Desflurane Protects The Brain Against The Oxidant Activity of Acute Hyperglycemia in Diabetic Rats, Comparison with Sevoflurane

Yazarlar:

Alican Kaya | Mustafa Arslan | Elif Beşkardeş | Ömer Kurtipek | Dilek Kalaycı | Alper Tunga Dogan | Ayşe Hande Arpacı | Işın Güneş | Mustafa Kavutcu

Yayıncı:

Gazi University

Ana Başlıklar:

Primary Health Care

Dergi:

Journal of Gazi University Health Sciences Institute Vol.5 Issue 1, pp.34-41

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001288537

pISSN:

2687-6353

Antioxidant system

Brain

Desflurane

Diabetes Mellitus

Sevoflurane

Sayı

Makale detayları

Desflurane Protects The Brain Against The Oxidant Activity of Acute Hyperglycemia in Diabetic Rats, Comparison with Sevoflurane

Yazarlar: Alican Kaya | Mustafa Arslan | Elif Beşkardeş | Ömer Kurtipek | Dilek Kalaycı | Alper Tunga Dogan | Ayşe Hande Arpacı | Işın Güneş | Mustafa Kavutcu

Yayıncı: Gazi University

Ana Başlıklar: Primary Health Care

Dergi: Journal of Gazi University Health Sciences Institute Vol.5 Issue 1, pp.34-41

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001288537

pISSN: 2687-6353

Antioxidant system

Brain

Desflurane

Diabetes Mellitus

Sevoflurane

Sayı

Yazarlar:

Alican Kaya | Mustafa Arslan | Elif Beşkardeş | Ömer Kurtipek | Dilek Kalaycı | Alper Tunga Dogan | Ayşe Hande Arpacı | Işın Güneş | Mustafa Kavutcu

Yayıncı:

Gazi University

Ana Başlıklar:

Primary Health Care

Dergi:

Journal of Gazi University Health Sciences Institute Vol.5 Issue 1, pp.34-41

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001288537

pISSN:

2687-6353