The assessment of serum uric acid-to-HDL cholesterol ratio as a new predictor of mortality in ST-elevation myocardial infarction:  a cross-sectional study

Ömer Genç; Abdullah Yıldırım; Eyüp Özkan

Makale detayları

The assessment of serum uric acid-to-HDL cholesterol ratio as a new predictor of mortality in ST-elevation myocardial infarction: a cross-sectional study

Yazarlar:

Ömer Genç | Abdullah Yıldırım | Eyüp Özkan

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kardiyoloji

Dergi:

Journal of Medicine and Palliative Care Vol.5 Issue 1, pp.57-64

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312447

pISSN:

2717-7505

Anahtar kelimeler:

Özet:

 Aims: The objective of this study was to evaluate the predictive efficacy of the Uric Acid-to-High Density Lipoprotein Cholesterol Ratio UHR as a novel inflammatory and metabolic marker for mortality in patients with ST-segment Elevation Myocardial Infarction STEMI. Methods: This retrospective, single-center, cross-sectional, observational study enrolled 1361 patients diagnosed with STEMI undergoing primary percutaneous coronary intervention PPCI from March 2021, to January 2022. The participants were categorized into two groups: those experiencing in-hospital mortality n100 and those without in-hospital mortality n1265. Results: In-hospital mortality occurred in 100 patients 7.3. UHR was notably higher in the mortality group compared to the non-mortality group 23.614.9 vs. 15.36.9, p0.001. Logistic regression analysis identified several independent determinants of in-hospital mortality among STEMI patients, including age odds ratio OR1.050, p0.001, the presence of DM OR2.077, p0.016, serum glucose OR1.004, p0.002, hemoglobin OR0.855, p0.020, White blood cell count OR1.064, p0.025, UHR OR1.683, p0.001, and SYNTAX score OR1.099, p0.001. Receiver operating characteristic curve analysis revealed that UHR13.9 determined in-hospital mortality in STEMI patients who underwent PPCI with 81.1 sensitivity and 49.2 specificity AUC0.668, p0.001 Conclusion: The UHR exhibited a significant and independent positive correlation with in-hospital mortality among STEMI patients undergoing PPCI.

 Aims: The objective of this study was to evaluate the predictive efficacy of the Uric Acid-to-High Density Lipoprotein Cholesterol Ratio UHR as a novel inflammatory and metabolic marker for mortality in patients with ST-segment Elevation Myocardial Infarction STEMI. Methods: This retrospective, single-center, cross-sectional, observational study enrolled 1361 patients diagnosed with STEMI undergoing primary percutaneous coronary intervention PPCI from March 2021, to January 2022. The participants were categorized into two groups: those experiencing in-hospital mortality n100 and those without in-hospital mortality n1265. Results: In-hospital mortality occurred in 100 patients 7.3. UHR was notably higher in the mortality group compared to the non-mortality group 23.614.9 vs. 15.36.9, p0.001. Logistic regression analysis identified several independent determinants of in-hospital mortality among STEMI patients, including age odds ratio OR1.050, p0.001, the presence of DM OR2.077, p0.016, serum glucose OR1.004, p0.002, hemoglobin OR0.855, p0.020, White blood cell count OR1.064, p0.025, UHR OR1.683, p0.001, and SYNTAX score OR1.099, p0.001. Receiver operating characteristic curve analysis revealed that UHR13.9 determined in-hospital mortality in STEMI patients who underwent PPCI with 81.1 sensitivity and 49.2 specificity AUC0.668, p0.001 Conclusion: The UHR exhibited a significant and independent positive correlation with in-hospital mortality among STEMI patients undergoing PPCI.

 Aims: The objective of this study was to evaluate the predictive efficacy of the Uric Acid-to-High Density Lipoprotein Cholesterol Ratio UHR as a novel inflammatory and metabolic marker for mortality in patients with ST-segment Elevation Myocardial Infarction STEMI. Methods: This retrospective, single-center, cross-sectional, observational study enrolled 1361 patients diagnosed with STEMI undergoing primary percutaneous coronary intervention PPCI from March 2021, to January 2022. The participants were categorized into two groups: those experiencing in-hospital mortality n100 and those without in-hospital mortality n1265. Results: In-hospital mortality occurred in 100 patients 7.3. UHR was notably higher in the mortality group compared to the non-mortality group 23.614.9 vs. 15.36.9, p0.001. Logistic regression analysis identified several independent determinants of in-hospital mortality among STEMI patients, including age odds ratio OR1.050, p0.001, the presence of DM OR2.077, p0.016, serum glucose OR1.004, p0.002, hemoglobin OR0.855, p0.020, White blood cell count OR1.064, p0.025, UHR OR1.683, p0.001, and SYNTAX score OR1.099, p0.001. Receiver operating characteristic curve analysis revealed that UHR13.9 determined in-hospital mortality in STEMI patients who underwent PPCI with 81.1 sensitivity and 49.2 specificity AUC0.668, p0.001 Conclusion: The UHR exhibited a significant and independent positive correlation with in-hospital mortality among STEMI patients undergoing PPCI.

 Giriş ve amaç: Bu çalışmanın amacı, ST-segment Yükselmeli Miyokard Enfarktüsü STYME geçiren hastalarda mortalite için yeni bir enflamatuar ve metabolik belirteç olarak Ürik Asit-Yüksek Dansiteli Lipoprotein Kolesterol Oranının ÜHO öngörücü etkinliğini değerlendirmektir. Yöntemler: Bu retrospektif, tek merkezli, kesitsel, gözlemsel çalışmaya Mart 2021 ile Ocak 2022 tarihleri arasında primer perkütan koroner girişim PPKG uygulanan STYMI tanılı 1361 hasta dahil edilmiştir. Katılımcılar iki gruba ayrılmıştır: hastane-içi mortalite gerçekleşen n100 ve gerçekleşmeyen n1265. Sonuçlar: Hastane-içi mortalite 100 hastada 7.3 meydana gelmiştir. ÜHO, mortalite grubunda mortalite olmayan gruba kıyasla belirgin şekilde daha yüksekti 23.614.9a karşı 15.36.9, p0.001. Lojistik regresyon analizi, STYMI hastaları arasında hastane-içi mortalitenin birkaç bağımsız belirleyicisi tanımlanmıştır, yaş risk oranı RO1.050, p0.001, DM varlığı RO2. 077, p0.016, serum glukozu RO1.004, p0.002, hemoglobin RO0.855, p0.020, beyaz kan hücresi sayısı RO1.064, p0.025, ÜHO RO1.683, p0.001 ve SYNTAX skoru R01.099, p0.001. Alıcı işletim karakteristik eğrisi analizi, ÜHO 13.9 un PPKG uygulanan STYMI hastalarında hastane içi mortaliteyi 81.1 duyarlılık ve 49.2 özgüllükle belirlediğini ortaya koymuştur EAA0.668, p0.001 Sonuçlar: ÜHO, PPKGI uygulanan STYMI hastaları arasında hastane-içi mortalite ile anlamlı ve bağımsız bir pozitif korelasyon sergilemiştir.

Makale detayları

The assessment of serum uric acid-to-HDL cholesterol ratio as a new predictor of mortality in ST-elevation myocardial infarction: a cross-sectional study

Yazarlar:

Ömer Genç | Abdullah Yıldırım | Eyüp Özkan

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kardiyoloji

Dergi:

Journal of Medicine and Palliative Care Vol.5 Issue 1, pp.57-64

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312447

pISSN:

2717-7505

Uric acid

HDL-C

uric acid-to-high density lipoprotein cholesterol ratio

STEMI

SYNTAX score

in-hospital mortalityÜrik Asit

HDL-K

Ürik Asit-Yüksek Dansiteli Lipoprotein Kolesterol Oranı

STYMI

SYNTAX skoru

Hastane-içi mortalite

Sayı

Makale detayları

Yazarlar: Ömer Genç | Abdullah Yıldırım | Eyüp Özkan

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Kardiyoloji

Dergi: Journal of Medicine and Palliative Care Vol.5 Issue 1, pp.57-64

Belge Tipi: Makale

Yayın Tarihi: 2/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001312447

pISSN: 2717-7505

Sayı

Yazarlar:

Ömer Genç | Abdullah Yıldırım | Eyüp Özkan

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kardiyoloji

Dergi:

Journal of Medicine and Palliative Care Vol.5 Issue 1, pp.57-64

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001312447

pISSN:

2717-7505