Traditional Medicinal Uses, Phytochemicals, and Pharmacological Activities of Genus Rhamnus: A review

Gashaw NİGUSSİE; Haregua MELAK; Milkyas ENDALE ANNİSA

doi:https://doi.org/10.18596/jotcsa.929188

Makale detayları

Traditional Medicinal Uses, Phytochemicals, and Pharmacological Activities of Genus Rhamnus: A review

Yazarlar:

Gashaw NİGUSSİE | Haregua MELAK | Milkyas ENDALE ANNİSA

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Kimya ve ilgili bilimler | İnsan psikolojisi

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry 2021 Vol.8 Issue 3, pp.899-932

Belge Tipi:

Makale

Yayın Tarihi:

8/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000502265

Sıklık:

Üç Aylık

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.929188

Özet:

 


The genus Rhamnus belongs to the Rhamnaceae family, which contains approximately 137 species, traditionally used as folk medicine in East Asia, North and South America, and subtropical regions of Africa. The genus is used traditionally to treat diseases such as cancer, wound, jaundice, hepatitis, gonorrhea, laxative, hypertension, malaria, stomach ache, snake bite and diarrhea. Anthraquinones and flavonoids are the most cited compounds from the genus of which polyphenols were abundant with tremendous antioxidant, wound healing and antiinflammatory activities. Pharmacological activity evaluation of the extracts and isolated compounds revealed anti-inflammatory, antioxidant, antimalarial, antibacterial, anti-mutagenic, anti-genotoxic, hepatoprotective, anticancer, and anti-proliferative activity. The genus afforded drug leads such as 6-methoxysorigenin (12) and prinoidin (23) with anti-tyrosinase and cytotoxicity, respectively, as well as antioxidant drug leads such as Kaempferol-3-O-β-rhamninoside (31) rhamnetin-3-O-β-isorhamninoside (37) and isotorachrysone (55). The present review endeavors to provide a comprehensive and up to date compilation of documented traditional medicinal uses, phytochemicals and pharmacological activities of the genus and provided valuable information in support of its uses as an alternative medicine for future healthcare practice.

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Makale detayları

Traditional Medicinal Uses, Phytochemicals, and Pharmacological Activities of Genus Rhamnus: A review

Yazarlar: Gashaw NİGUSSİE | Haregua MELAK | Milkyas ENDALE ANNİSA

Yayıncı: Turkish Chemical Society

Ana Başlıklar: Kimya ve ilgili bilimler | İnsan psikolojisi

Dergi: Journal of the Turkish Chemical Society Section A: Chemistry 2021 Vol.8 Issue 3, pp.899-932

Belge Tipi: Makale

Yayın Tarihi: 8/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000502265

Sıklık: Üç Aylık

eISSN: 2149-0120

DOI: https://doi.org/10.18596/jotcsa.929188

Sayı

Yazarlar:

Gashaw NİGUSSİE | Haregua MELAK | Milkyas ENDALE ANNİSA

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Kimya ve ilgili bilimler | İnsan psikolojisi

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry 2021 Vol.8 Issue 3, pp.899-932

Belge Tipi:

Makale

Yayın Tarihi:

8/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000502265

Sıklık:

Üç Aylık

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.929188