Relationship between contrast media-induced nephropathy and CANLPH score in patients with ST-segment elevation myocardial infarction

Birsen Doğanay; Ozlem Ozcan Celebi

Makale detayları

Relationship between contrast media-induced nephropathy and CANLPH score in patients with ST-segment elevation myocardial infarction

Yazarlar:

Birsen Doğanay | Ozlem Ozcan Celebi

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Anatolian Current Medical Journal Vol.5 Issue 2, pp.130-137

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286200

pISSN:

2718-0115

Anahtar kelimeler:

Özet:

 Aim: Contrast-induced nephropathy CIN, a significant complication of percutaneous coronary intervention PCI, is related to increased morbidity and mortality. It has been suggested that inflammation plays an important role in the development of CIN. This study aimed to investigate the prognostic role of the CANLPH score, a new indicator of inflammation, in predicting CIN and in-hospital mortality among patients with ST-segment elevation myocardial infarction STEMI undergoing PCI. Material and Method: This retrospective study included 1475 patients with STEMI undergoing PCI. CIN was defined as a 25 or 0.5 mgdL increase in serum creatinine compared to the baseline value within 48 h after PCI. The preprocedural modified Mehran score was calculated for each patient. The CANLPH score was derived from the cut-off points of the plateletlymphocyte ratio, neutrophillymphocyte ratio, and platelethemoglobin ratio to predict CIN. Results: The mean age of the patients was 62.014.3 years and the majority were male 69.8. The incidence of CIN was determined as 11.5. Multivariable regression analysis showed that increased CANLPH score OR4.49, p0.001 and increased modified Mehran score OR1.27, p0.001 were independent predictors of CIN. The threshold value of the CANLPH score in predicting CIN was 1 with 73.5 sensitivity and 78.2 specificity and it exhibited better diagnostic performance than other inflammatory indices in predicting CIN and in-hospital mortality. Conclusion: Prior to planned PCI, the CANLPH score has superior diagnostic performance in predicting CIN and mortality, and it may guide decisions about preventive measures and treatments.

 Aim: Contrast-induced nephropathy CIN, a significant complication of percutaneous coronary intervention PCI, is related to increased morbidity and mortality. It has been suggested that inflammation plays an important role in the development of CIN. This study aimed to investigate the prognostic role of the CANLPH score, a new indicator of inflammation, in predicting CIN and in-hospital mortality among patients with ST-segment elevation myocardial infarction STEMI undergoing PCI. Material and Method: This retrospective study included 1475 patients with STEMI undergoing PCI. CIN was defined as a 25 or 0.5 mgdL increase in serum creatinine compared to the baseline value within 48 h after PCI. The preprocedural modified Mehran score was calculated for each patient. The CANLPH score was derived from the cut-off points of the plateletlymphocyte ratio, neutrophillymphocyte ratio, and platelethemoglobin ratio to predict CIN. Results: The mean age of the patients was 62.014.3 years and the majority were male 69.8. The incidence of CIN was determined as 11.5. Multivariable regression analysis showed that increased CANLPH score OR4.49, p0.001 and increased modified Mehran score OR1.27, p0.001 were independent predictors of CIN. The threshold value of the CANLPH score in predicting CIN was 1 with 73.5 sensitivity and 78.2 specificity and it exhibited better diagnostic performance than other inflammatory indices in predicting CIN and in-hospital mortality. Conclusion: Prior to planned PCI, the CANLPH score has superior diagnostic performance in predicting CIN and mortality, and it may guide decisions about preventive measures and treatments.

 Aim: Contrast-induced nephropathy CIN, a significant complication of percutaneous coronary intervention PCI, is related to increased morbidity and mortality. It has been suggested that inflammation plays an important role in the development of CIN. This study aimed to investigate the prognostic role of the CANLPH score, a new indicator of inflammation, in predicting CIN and in-hospital mortality among patients with ST-segment elevation myocardial infarction STEMI undergoing PCI. Material and Method: This retrospective study included 1475 patients with STEMI undergoing PCI. CIN was defined as a 25 or 0.5 mgdL increase in serum creatinine compared to the baseline value within 48 h after PCI. The preprocedural modified Mehran score was calculated for each patient. The CANLPH score was derived from the cut-off points of the plateletlymphocyte ratio, neutrophillymphocyte ratio, and platelethemoglobin ratio to predict CIN. Results: The mean age of the patients was 62.014.3 years and the majority were male 69.8. The incidence of CIN was determined as 11.5. Multivariable regression analysis showed that increased CANLPH score OR4.49, p0.001 and increased modified Mehran score OR1.27, p0.001 were independent predictors of CIN. The threshold value of the CANLPH score in predicting CIN was 1 with 73.5 sensitivity and 78.2 specificity and it exhibited better diagnostic performance than other inflammatory indices in predicting CIN and in-hospital mortality. Conclusion: Prior to planned PCI, the CANLPH score has superior diagnostic performance in predicting CIN and mortality, and it may guide decisions about preventive measures and treatments.

 Amaç: Perkütan koroner girişimin PCI önemli bir komplikasyonu olan kontrast kaynaklı nefropati CIN, artmış morbidite ve mortalite ile ilişkilidir. Enflamasyonun CIN gelişiminde önemli bir rol oynadığı ileri sürülmektedir. Bu çalışmanın amacı, PCI uygulanan ST segment yükselmeli miyokard infarktüsü STEMI olan hastalarda CIN ve hastane içi mortaliteyi öngörmede inflamasyonun yeni bir göstergesi olan CANLPH skorunun prognostik rolünü araştırmaktı. Materyal ve Metot: Bu retrospektif çalışma, PCI uygulanan STEMIli 1475 hastayı içermektedir. CIN, PKGden sonraki 48 saat içinde başlangıç değerine kıyasla serum kreatinin değerinde 25 veya 0,5 mgdL artış olarak tanımlandı. Her hasta için Mehran skoru hesaplandı. CANLPH skoru, CINi tahmin etmek için trombositlenfosit oranı, nötrofillenfosit oranı ve trombosithemoglobin oranının eşik değerlerinden elde edildi. Bulgular: Hastaların ortalama yaşı 62,0  14,3 yıl ve çoğunluğu erkekti 69,8. CIN insidansı 11,5 olarak belirlendi. Çok değişkenli regresyon analizi, artan CANLPH skorunun OR  4,48, p  0,001 ve artan Mehran skorunun OR  1,31, p  0,001 CINin bağımsız belirleyicileri olduğunu gösterdi. CANLPH skorunun CINi öngörmedeki eşik değeri 73,5 duyarlılık ve 78,2 özgüllük ile 1 olarak belirlendi. CANLPH skoru CIN ve hastane içi mortaliteyi öngörmede diğer inflamatuar indekslerden daha iyi tanısal performans sergiledi. Sonuç: Planlanan PCI öncesinde CANLPH skoru, CIN ve mortaliteyi öngörmede üstün tanısal performansa sahiptir ve önleyici tedbirler ve tedavi kararları için rehberlik edebilir.

Makale detayları

Relationship between contrast media-induced nephropathy and CANLPH score in patients with ST-segment elevation myocardial infarction

Yazarlar:

Birsen Doğanay | Ozlem Ozcan Celebi

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Anatolian Current Medical Journal Vol.5 Issue 2, pp.130-137

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286200

pISSN:

2718-0115

Biomarkers

contrast-induced nephropathy

inflammation

myocardial infarction

biyobelirteç

kontrast kaynaklı nefropati

inflamasyon

miyokard enfarktüsü

Sayı

Makale detayları

Yazarlar: Birsen Doğanay | Ozlem Ozcan Celebi

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Sağlık Kurumları Yönetimi

Dergi: Anatolian Current Medical Journal Vol.5 Issue 2, pp.130-137

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001286200

pISSN: 2718-0115

Sayı

Yazarlar:

Birsen Doğanay | Ozlem Ozcan Celebi

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Anatolian Current Medical Journal Vol.5 Issue 2, pp.130-137

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286200

pISSN:

2718-0115