Effects of cepae extract, allantoin, and heparin mixture on developing and already formed epidural fibrosis in a rat laminectomy model

Rafet ÖZAY; Osman Yüksel YAVUZ; Abit AKTAŞ; Funda YİĞİT; Nuri Eralp ÇETİNALP; Haci Mustafa ÖZDEMİR; Zeki ŞEKERCİ

Makale detayları

Effects of cepae extract, allantoin, and heparin mixture on developing and already formed epidural fibrosis in a rat laminectomy model

Yazarlar:

Rafet ÖZAY | Osman Yüksel YAVUZ | Abit AKTAŞ | Funda YİĞİT | Nuri Eralp ÇETİNALP | Haci Mustafa ÖZDEMİR | Zeki ŞEKERCİ

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 4, pp.1233-1239

Belge Tipi:

Makale

Yayın Tarihi:

7/2016

Belge Dili:

İngilizce

Document ID (Org No.):

2000751995

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: The study was designed to investigate whether local administration of a mixture composed of cepae extract, allantoin, and heparin (CAH) decreased already formed epidural fibrosis (EF) at the laminectomy site.   Materials and methods: Twenty-four adult male Sprague Dawley rats were equally divided into four groups. Laminectomy was performed at the L5 level in all rats. The group 2 and group 4 rats were treated with local drug administration. While the group 1 and 2 rats were sacrificed after 6 weeks, the remaining rats were reoperated and CAH mixture was applied in group 4. The vertebral columns of all rats were removed en bloc. Fibroblast numbers, EF, and arachnoidal involvement (AI) were evaluated.  Results: The results of the treatment groups were separately compared with the control groups. The numbers of fibroblasts in the treatment groups were significantly lower than those in the control groups (P < 0.001). The grade of EF in group 2 was significantly less than that in group 1 (P < 0.05). There was no statistically significant difference regarding EF and AI grade between group 3 and group 4, and local application of the drug on EF and AI yielded better results than in the control groups.  Conclusion: The mixture composed of CAH might be a successful candidate for preventing EF in clinical practice.

Makale detayları

Effects of cepae extract, allantoin, and heparin mixture on developing and already formed epidural fibrosis in a rat laminectomy model

Yazarlar: Rafet ÖZAY | Osman Yüksel YAVUZ | Abit AKTAŞ | Funda YİĞİT | Nuri Eralp ÇETİNALP | Haci Mustafa ÖZDEMİR | Zeki ŞEKERCİ

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2016 Vol.46 Issue 4, pp.1233-1239

Belge Tipi: Makale

Yayın Tarihi: 7/2016

Belge Dili: İngilizce

Document ID (Org No.): 2000751995

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Rafet ÖZAY | Osman Yüksel YAVUZ | Abit AKTAŞ | Funda YİĞİT | Nuri Eralp ÇETİNALP | Haci Mustafa ÖZDEMİR | Zeki ŞEKERCİ

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 4, pp.1233-1239

Belge Tipi:

Makale

Yayın Tarihi:

7/2016

Belge Dili:

İngilizce

Document ID (Org No.):

2000751995

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144