Brain Damage from Lung Ischemia-Reperfusion Injury, Its Predisposition to Alzheimer's Disease, and the Potential Impact of Riociguat

Özlem Özmen; Adem Milletsever; Halil Aşçı

Makale detayları

Brain Damage from Lung Ischemia-Reperfusion Injury, Its Predisposition to Alzheimer's Disease, and the Potential Impact of Riociguat

Yazarlar:

Özlem Özmen | Adem Milletsever | Halil Aşçı

Yayıncı:

Burdur Mehmet Akif Ersoy University

Ana Başlıklar:

Veterinary Pathology

Dergi:

Mediterranean Veterinary Journal Vol.10 Issue 1, pp.439-447

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347259

pISSN:

3023-8447

Anahtar kelimeler:

Özet:

 Lung ischemia and reperfusion LIR injury can lead to systemic and neurological complications, potentially exacerbating Alzheimers disease AD. Riociguat RIO has shown promise in reducing ischemia-reperfusion injuries. LIR-induced neuroinflammation in brain tissue contributes to beta amyloid Aβ accumulation. This study hypothesizes that RIO could mitigate AD progression by reducing brain damage, neuroinflammation, and Aβ accumulation secondary to LIR. Forty Wistar Albino male rats were randomly divided into 4 groups: sham, LIR, LIRRIO, and RIO. LIR was induced using a vascular clamp on the hilus for 60 minutes, followed by 60 minutes of reperfusion. RIO was administered 30 minutes before ischemia. Brain tissues were analyzed histopathologically and immunohistochemically. Histopathology revealed marked hyperemia, degenerative changes, neuronal loss, gliosis, and inflammatory cell infiltrations in the LIR group. Immunohistochemical analysis showed increased Aβ, Cas-3, and TNF-α levels. RIO treatment effectively reversed these changes, indicating its potential in reducing brain damage, neuroinflammation, and Aβ accumulation. The results suggest that brain changes following lung ischemia-reperfusion in a rat model may predispose to Alzheimers disease, but RIO may be effective in preventing this condition.

 Lung ischemia and reperfusion LIR injury can lead to systemic and neurological complications, potentially exacerbating Alzheimers disease AD. Riociguat RIO has shown promise in reducing ischemia-reperfusion injuries. LIR-induced neuroinflammation in brain tissue contributes to beta amyloid Aβ accumulation. This study hypothesizes that RIO could mitigate AD progression by reducing brain damage, neuroinflammation, and Aβ accumulation secondary to LIR. Forty Wistar Albino male rats were randomly divided into 4 groups: sham, LIR, LIRRIO, and RIO. LIR was induced using a vascular clamp on the hilus for 60 minutes, followed by 60 minutes of reperfusion. RIO was administered 30 minutes before ischemia. Brain tissues were analyzed histopathologically and immunohistochemically. Histopathology revealed marked hyperemia, degenerative changes, neuronal loss, gliosis, and inflammatory cell infiltrations in the LIR group. Immunohistochemical analysis showed increased Aβ, Cas-3, and TNF-α levels. RIO treatment effectively reversed these changes, indicating its potential in reducing brain damage, neuroinflammation, and Aβ accumulation. The results suggest that brain changes following lung ischemia-reperfusion in a rat model may predispose to Alzheimers disease, but RIO may be effective in preventing this condition.

 Lung ischemia and reperfusion LIR injury can lead to systemic and neurological complications, potentially exacerbating Alzheimers disease AD. Riociguat RIO has shown promise in reducing ischemia-reperfusion injuries. LIR-induced neuroinflammation in brain tissue contributes to beta amyloid Aβ accumulation. This study hypothesizes that RIO could mitigate AD progression by reducing brain damage, neuroinflammation, and Aβ accumulation secondary to LIR. Forty Wistar Albino male rats were randomly divided into 4 groups: sham, LIR, LIRRIO, and RIO. LIR was induced using a vascular clamp on the hilus for 60 minutes, followed by 60 minutes of reperfusion. RIO was administered 30 minutes before ischemia. Brain tissues were analyzed histopathologically and immunohistochemically. Histopathology revealed marked hyperemia, degenerative changes, neuronal loss, gliosis, and inflammatory cell infiltrations in the LIR group. Immunohistochemical analysis showed increased Aβ, Cas-3, and TNF-α levels. RIO treatment effectively reversed these changes, indicating its potential in reducing brain damage, neuroinflammation, and Aβ accumulation. The results suggest that brain changes following lung ischemia-reperfusion in a rat model may predispose to Alzheimers disease, but RIO may be effective in preventing this condition.

 Lung ischemia and reperfusion LIR injury can lead to systemic and neurological complications, potentially exacerbating Alzheimers disease AD. Riociguat RIO has shown promise in reducing ischemia-reperfusion injuries. LIR-induced neuroinflammation in brain tissue contributes to beta amyloid Aβ accumulation. This study hypothesizes that RIO could mitigate AD progression by reducing brain damage, neuroinflammation, and Aβ accumulation secondary to LIR. Forty Wistar Albino male rats were randomly divided into 4 groups: sham, LIR, LIRRIO, and RIO. LIR was induced using a vascular clamp on the hilus for 60 minutes, followed by 60 minutes of reperfusion. RIO was administered 30 minutes before ischemia. Brain tissues were analyzed histopathologically and immunohistochemically. Histopathology revealed marked hyperemia, degenerative changes, neuronal loss, gliosis, and inflammatory cell infiltrations in the LIR group. Immunohistochemical analysis showed increased Aβ, Cas-3, and TNF-α levels. RIO treatment effectively reversed these changes, indicating its potential in reducing brain damage, neuroinflammation, and Aβ accumulation. The results suggest that brain changes following lung ischemia-reperfusion in a rat model may predispose to Alzheimers disease, but RIO may be effective in preventing this condition.

Makale detayları

Brain Damage from Lung Ischemia-Reperfusion Injury, Its Predisposition to Alzheimer's Disease, and the Potential Impact of Riociguat

Yazarlar:

Özlem Özmen | Adem Milletsever | Halil Aşçı

Yayıncı:

Burdur Mehmet Akif Ersoy University

Ana Başlıklar:

Veterinary Pathology

Dergi:

Mediterranean Veterinary Journal Vol.10 Issue 1, pp.439-447

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347259

pISSN:

3023-8447

Riociguat

Alzheimer

neuroprotection

inflammation

apoptosis

Lung ischemia-reperfusion

Sayı

Makale detayları

Brain Damage from Lung Ischemia-Reperfusion Injury, Its Predisposition to Alzheimer's Disease, and the Potential Impact of Riociguat

Yazarlar: Özlem Özmen | Adem Milletsever | Halil Aşçı

Yayıncı: Burdur Mehmet Akif Ersoy University

Ana Başlıklar: Veterinary Pathology

Dergi: Mediterranean Veterinary Journal Vol.10 Issue 1, pp.439-447

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347259

pISSN: 3023-8447

Riociguat

Alzheimer

neuroprotection

inflammation

apoptosis

Lung ischemia-reperfusion

Sayı

Yazarlar:

Özlem Özmen | Adem Milletsever | Halil Aşçı

Yayıncı:

Burdur Mehmet Akif Ersoy University

Ana Başlıklar:

Veterinary Pathology

Dergi:

Mediterranean Veterinary Journal Vol.10 Issue 1, pp.439-447

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347259

pISSN:

3023-8447