The relation between gleason score, and nuclear size and shape factors in prostatic adenocarcinoma

Sibel BEKTAŞ

Makale detayları

The relation between gleason score, and nuclear size and shape factors in prostatic adenocarcinoma

Yazarlar:

Sibel BEKTAŞ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 3, pp.381-387

Belge Tipi:

Makale

Yayın Tarihi:

2/2009

Belge Dili:

Türkçe

Document ID (Org No.):

2000755436

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Aim: The aim of this study was to assess the size and shape characteristics of prostatic adenocarcinoma cell nuclei using a computer-assisted analysis system, and to compare the results with the Gleason score.    Materials and Methods: Morphometric nuclear parameters, such as roundness factor, form ellipse, area, length, and perimeter, were evaluated based on specimen slides of 130 prostatic adenocarcinoma cases (77% needle biopsies and 23% prostatectomy specimens) using a computerized image analysis system. Correlation analysis between Gleason score and morphometric results was performed.    Results: The Gleason score was correlated with mean nuclear area (r = 0.516, P = 0.01), mean nuclear length (r = 0.298, P = 0.01), and mean nuclear perimeter (r = 0.303, P = 0.01) for all specimens. In the needle biopsy group the Gleason score was correlated with mean nuclear area (r = 0.522, P = 0.01), mean nuclear length (r = 0.398, P = 0.01), and mean nuclear perimeter (r = 0.432, P = 0.01), whereas in the prostatectomy group the Gleason score was correlated only with mean nuclear area (s = 0.619, P = 0.01) and mean nuclear roundness factor (s = -0.425, P = 0.05).     Conclusions: Nuclear size and shape factors, especially mean nuclear area, were concordant with the Gleason score. Nuclear size and shape assessment may aid in the evaluation of the pathological status of prostatic adenocarcinoma.

 

Aim: The aim of this study was to assess the size and shape characteristics of prostatic adenocarcinoma cell nuclei using a computer-assisted analysis system, and to compare the results with the Gleason score.    Materials and Methods: Morphometric nuclear parameters, such as roundness factor, form ellipse, area, length, and perimeter, were evaluated based on specimen slides of 130 prostatic adenocarcinoma cases (77% needle biopsies and 23% prostatectomy specimens) using a computerized image analysis system. Correlation analysis between Gleason score and morphometric results was performed.    Results: The Gleason score was correlated with mean nuclear area (r = 0.516, P = 0.01), mean nuclear length (r = 0.298, P = 0.01), and mean nuclear perimeter (r = 0.303, P = 0.01) for all specimens. In the needle biopsy group the Gleason score was correlated with mean nuclear area (r = 0.522, P = 0.01), mean nuclear length (r = 0.398, P = 0.01), and mean nuclear perimeter (r = 0.432, P = 0.01), whereas in the prostatectomy group the Gleason score was correlated only with mean nuclear area (s = 0.619, P = 0.01) and mean nuclear roundness factor (s = -0.425, P = 0.05).     Conclusions: Nuclear size and shape factors, especially mean nuclear area, were concordant with the Gleason score. Nuclear size and shape assessment may aid in the evaluation of the pathological status of prostatic adenocarcinoma.

Makale detayları

The relation between gleason score, and nuclear size and shape factors in prostatic adenocarcinoma

Yazarlar:

Sibel BEKTAŞ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 3, pp.381-387

Belge Tipi:

Makale

Yayın Tarihi:

2/2009

Belge Dili:

Türkçe

Document ID (Org No.):

2000755436

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Gleason score

nuclear size

nuclear shape

prostatic adenocarcinoma

Sayı

Makale detayları

The relation between gleason score, and nuclear size and shape factors in prostatic adenocarcinoma

Yazarlar: Sibel BEKTAŞ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2009 Vol.39 Issue 3, pp.381-387

Belge Tipi: Makale

Yayın Tarihi: 2/2009

Belge Dili: Türkçe

Document ID (Org No.): 2000755436

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Gleason score

nuclear size

nuclear shape

prostatic adenocarcinoma

Sayı

Yazarlar:

Sibel BEKTAŞ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 3, pp.381-387

Belge Tipi:

Makale

Yayın Tarihi:

2/2009

Belge Dili:

Türkçe

Document ID (Org No.):

2000755436

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144