Evaluation of the Relationship Between Breast Cancer Subtypes and Serum Inflammatory Markers

Zeliha Türkyılmaz; Tuğrul Demirel

Makale detayları

Evaluation of the Relationship Between Breast Cancer Subtypes and Serum Inflammatory Markers

Yazarlar:

Zeliha Türkyılmaz | Tuğrul Demirel

Yayıncı:

Bandirma Onyedi Eylul University

Ana Başlıklar:

Cerrahi (Diğer)

Dergi:

Hipokrat Tıp Dergisi Vol.3 Issue 3, pp.1-6

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001305587

pISSN:

2791-9935

Anahtar kelimeler:

Özet:

 Introduction: Breast cancer is the most common cancer in women. Luminal A, luminal B, cerbB2 enriched type , Triple negative molecular subtypes have been defined. This study aimed to reveal the relationship between molecular subtypes and inflammatory markers. Material and Methods: Breast cancer patients who were operated between January 2019 and April 2023 were evaluated. Demographic characteristics, pathology assessments, molecular subtypes and laboratory data of the patients were collected. NeutrophilLymphocyte ratio NLR, PlateletLymphocyte ratio PLR and Systemic Inflammatory Response Index SIRI were calculated from the hemogram. The relationship between molecular subtypes and inflammatory markers was statistically evaluated. Results: The median age of the patients included in the study was 56 years. Among the patients, 82.8 tested positive for estrogen receptor ER, while 61.3 tested positive for progesterone receptor PR. The most common molecular subtype was luminal A. When the cut-off value for Ki67 was 14, a statistically significant correlation was found between ER status p0.047. When Ki67 cut-off value was set to 20, a statistically significant relationship was observed with ER p0.002 and a statistically significant relationship with PR p0.025. Median values of NLR and PLR were 1.9 range, 0.7:21.3 and 123 range, 53.3:252, respectively. Conclusions: We did not find a significant relationship between breast cancer subtypes and inflammatory markers. However, the tendency to show a statistically significant difference between cerbB2 and PLR and SIRI was remarkable p0.08, p0.057, respectively.

 Introduction: Breast cancer is the most common cancer in women. Luminal A, luminal B, cerbB2 enriched type , Triple negative molecular subtypes have been defined. This study aimed to reveal the relationship between molecular subtypes and inflammatory markers. Material and Methods: Breast cancer patients who were operated between January 2019 and April 2023 were evaluated. Demographic characteristics, pathology assessments, molecular subtypes and laboratory data of the patients were collected. NeutrophilLymphocyte ratio NLR, PlateletLymphocyte ratio PLR and Systemic Inflammatory Response Index SIRI were calculated from the hemogram. The relationship between molecular subtypes and inflammatory markers was statistically evaluated. Results: The median age of the patients included in the study was 56 years. Among the patients, 82.8 tested positive for estrogen receptor ER, while 61.3 tested positive for progesterone receptor PR. The most common molecular subtype was luminal A. When the cut-off value for Ki67 was 14, a statistically significant correlation was found between ER status p0.047. When Ki67 cut-off value was set to 20, a statistically significant relationship was observed with ER p0.002 and a statistically significant relationship with PR p0.025. Median values of NLR and PLR were 1.9 range, 0.7:21.3 and 123 range, 53.3:252, respectively. Conclusions: We did not find a significant relationship between breast cancer subtypes and inflammatory markers. However, the tendency to show a statistically significant difference between cerbB2 and PLR and SIRI was remarkable p0.08, p0.057, respectively.

 Introduction: Breast cancer is the most common cancer in women. Luminal A, luminal B, cerbB2 enriched type , Triple negative molecular subtypes have been defined. This study aimed to reveal the relationship between molecular subtypes and inflammatory markers. Material and Methods: Breast cancer patients who were operated between January 2019 and April 2023 were evaluated. Demographic characteristics, pathology assessments, molecular subtypes and laboratory data of the patients were collected. NeutrophilLymphocyte ratio NLR, PlateletLymphocyte ratio PLR and Systemic Inflammatory Response Index SIRI were calculated from the hemogram. The relationship between molecular subtypes and inflammatory markers was statistically evaluated. Results: The median age of the patients included in the study was 56 years. Among the patients, 82.8 tested positive for estrogen receptor ER, while 61.3 tested positive for progesterone receptor PR. The most common molecular subtype was luminal A. When the cut-off value for Ki67 was 14, a statistically significant correlation was found between ER status p0.047. When Ki67 cut-off value was set to 20, a statistically significant relationship was observed with ER p0.002 and a statistically significant relationship with PR p0.025. Median values of NLR and PLR were 1.9 range, 0.7:21.3 and 123 range, 53.3:252, respectively. Conclusions: We did not find a significant relationship between breast cancer subtypes and inflammatory markers. However, the tendency to show a statistically significant difference between cerbB2 and PLR and SIRI was remarkable p0.08, p0.057, respectively.

 Amaç: Meme kanseri kadınlarda en sık görülen kanserdir. Meme kanserinin, luminal A, luminal B, cerbB2den zengin tip, triple negatif moleküler subtipleri tanımlanmıştır. Bu çalışma moleküler subtipler ile enflamatuar belirteçler arasındaki ilişkiyi ortayı koymayı amaçlamıştır. Gereç ve Yöntemler: Ocak 2019 ve Nisan 2023 tarihleri arasında opere edilen meme kanseri hastaları değerlendirmeye alındı. Hastaların demografik özellikleri, patoji değerlendirmeleri, moleküler alt tipleri ve labaratuvar verileri toplandı. Hemogramdan NötrofilLenfosit oranı NLR, TrombositLenfosit oranı PLR ve Sistemik Enflamatuvar Yanıt İndeksi SIRI hesaplandı. Moleküler alt tipler ile enflamatuar belirteçler arasında ilişki istatistiksel olarak değerlendirildi. Bulgular: Çalışmaya dahil edilen hastaların ortanca yaşı 56 idi. Hastaların 82,8inde östrojen reseptörü ER, 61,3ünde progesteron reseptörü PR pozitif çıktı. En yaygın moleküler alt tip lümen A idi. Ki67 kesme değeri 14 olduğunda ER durumu arasında istatistiksel olarak anlamlı bir ilişki bulundu p0,047. Ki67 cut-off değeri 20 olarak alındığında hem ER ile p0,002, hem de PR ile istatistiksel olarak anlamlı ilişki p0,025 gözlendi. NLR ve PLRnin ortanca değerleri sırasıyla 1,9 aralık, 0,7:21,3 ve 123 aralık, 53,3:252 idi. Sonuç: Meme kanseri alt tipleri ile inflamatuar belirteçler arasında anlamlı bir ilişki bulamadık. Ancak cerbB2 ile PLR ve SIRI arasında istatistiksel olarak anlamlı fark gösterme eğilimi dikkat çekiciydi sırasıyla p0.08, p0.057.

Makale detayları

Evaluation of the Relationship Between Breast Cancer Subtypes and Serum Inflammatory Markers

Yazarlar:

Zeliha Türkyılmaz | Tuğrul Demirel

Yayıncı:

Bandirma Onyedi Eylul University

Ana Başlıklar:

Cerrahi (Diğer)

Dergi:

Hipokrat Tıp Dergisi Vol.3 Issue 3, pp.1-6

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001305587

pISSN:

2791-9935

Breast cancer

Neutrophil lymphocyte ratio

Platelet lymphocyte ratio

Systemic Inflammatory Response Index

Ki67Meme kanseri

Nötrofil lenfosit oranı

Trombosit lenfosit oranı

SIRI

Ki67

Sayı

Makale detayları

Yazarlar: Zeliha Türkyılmaz | Tuğrul Demirel

Yayıncı: Bandirma Onyedi Eylul University

Ana Başlıklar: Cerrahi (Diğer)

Dergi: Hipokrat Tıp Dergisi Vol.3 Issue 3, pp.1-6

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001305587

pISSN: 2791-9935

Sayı

Yazarlar:

Zeliha Türkyılmaz | Tuğrul Demirel

Yayıncı:

Bandirma Onyedi Eylul University

Ana Başlıklar:

Cerrahi (Diğer)

Dergi:

Hipokrat Tıp Dergisi Vol.3 Issue 3, pp.1-6

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001305587

pISSN:

2791-9935