Ki-67 Proliferation Index Positivity Limit (Cut-off) Value in Meningiomas

Neşe Yeldir; Ezgi Doğan; Hatice Özer; Burçak Söylemez; Serkan Çelikgün; Reyhan Eğilmez

Makale detayları

Ki-67 Proliferation Index Positivity Limit (Cut-off) Value in Meningiomas

Yazarlar:

Neşe Yeldir | Ezgi Doğan | Hatice Özer | Burçak Söylemez | Serkan Çelikgün | Reyhan Eğilmez

Yayıncı:

Bolu Abant Izzet Baysal University

Ana Başlıklar:

Clinical Sciences

Dergi:

Abant Medical Journal Vol.12 Issue 1, pp.43-50

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001287815

pISSN:

1305-4392

Anahtar kelimeler:

Özet:

 Objective: Meningiomas are usually slow-growing grade 1 tumors according to World Health Organization WHO classification. Histological and molecular criterias were defined for the determination of meningiomas of high grade and more aggressive. The proliferation activity is also considered among histopathological criterias. A commonly used parameter for determining proliferation activity is the Ki-67 index. This study was formed retrospectively to identife the positivity limit cut-off value of the Ki-67 proliferation index in cases diagnosed with meningioma. Materials and Methods: The Ki-67 indices of a total 190 patients diagnosed with meningioma was compared with the histological degrees of the tumors. The ROC analysis method was used in the statistical analysis for Ki-67 values. Results: The mean Ki-67 proliferation index was found to be 6.3 for grade 1, 11.2 for grade 2 and 26 for grade 3 in the cases diagnosed with meningioma in our center. The Ki-67 proliferation index, which can be used in addition to histopathological findings in the distinction of grade 1 and grade 2 meningiomas in our laboratory, was determined as a positivity limit value of 6.5 p0.05. Conclusion: The Ki-67 proliferation index in meningioma is an important parameter that can be used to determine the histological grade of atypical meningioma in particular. Although the index seems to be easy to use, it is a value that can create difficulties in borderline cases and also in interobserver and intraobserver evaluations. Therefore, each pathology laboratory should determine the Ki-67 value that they can accept as a limit for meningioma grading.

 Objective: Meningiomas are usually slow-growing grade 1 tumors according to World Health Organization WHO classification. Histological and molecular criterias were defined for the determination of meningiomas of high grade and more aggressive. The proliferation activity is also considered among histopathological criterias. A commonly used parameter for determining proliferation activity is the Ki-67 index. This study was formed retrospectively to identife the positivity limit cut-off value of the Ki-67 proliferation index in cases diagnosed with meningioma. Materials and Methods: The Ki-67 indices of a total 190 patients diagnosed with meningioma was compared with the histological degrees of the tumors. The ROC analysis method was used in the statistical analysis for Ki-67 values. Results: The mean Ki-67 proliferation index was found to be 6.3 for grade 1, 11.2 for grade 2 and 26 for grade 3 in the cases diagnosed with meningioma in our center. The Ki-67 proliferation index, which can be used in addition to histopathological findings in the distinction of grade 1 and grade 2 meningiomas in our laboratory, was determined as a positivity limit value of 6.5 p0.05. Conclusion: The Ki-67 proliferation index in meningioma is an important parameter that can be used to determine the histological grade of atypical meningioma in particular. Although the index seems to be easy to use, it is a value that can create difficulties in borderline cases and also in interobserver and intraobserver evaluations. Therefore, each pathology laboratory should determine the Ki-67 value that they can accept as a limit for meningioma grading.

 Objective: Meningiomas are usually slow-growing grade 1 tumors according to World Health Organization WHO classification. Histological and molecular criterias were defined for the determination of meningiomas of high grade and more aggressive. The proliferation activity is also considered among histopathological criterias. A commonly used parameter for determining proliferation activity is the Ki-67 index. This study was formed retrospectively to identife the positivity limit cut-off value of the Ki-67 proliferation index in cases diagnosed with meningioma. Materials and Methods: The Ki-67 indices of a total 190 patients diagnosed with meningioma was compared with the histological degrees of the tumors. The ROC analysis method was used in the statistical analysis for Ki-67 values. Results: The mean Ki-67 proliferation index was found to be 6.3 for grade 1, 11.2 for grade 2 and 26 for grade 3 in the cases diagnosed with meningioma in our center. The Ki-67 proliferation index, which can be used in addition to histopathological findings in the distinction of grade 1 and grade 2 meningiomas in our laboratory, was determined as a positivity limit value of 6.5 p0.05. Conclusion: The Ki-67 proliferation index in meningioma is an important parameter that can be used to determine the histological grade of atypical meningioma in particular. Although the index seems to be easy to use, it is a value that can create difficulties in borderline cases and also in interobserver and intraobserver evaluations. Therefore, each pathology laboratory should determine the Ki-67 value that they can accept as a limit for meningioma grading.

 Amaç: Meningiomlar genellikle yavaş büyüyen Dünya Sağlık Örgütü DSÖ sınıflandırma sistemine göre derece 1 tümörlerdir. Meningiomların yüksek derece ve daha agresif olduğunu belirleyebilmek için bazı histolojik ve moleküler özellikler tanımlanmıştır. Proliferasyon aktivitesi bu histopatolojik özellikler arasında yer almaktadır. Proliferasyon aktivitesini belirlemek için kullanılan en yaygın parametrelerden biri Ki-67 indeksidir. Gereç ve Yöntemler: Bu çalışma retrospektif olarak meningiom tanılı olgularda Ki-67 proliferasyon indeksinin pozitiflik sınır değerinin belirlenmesi için yapıldı. Meningiom tanısı alan toplam 190 hastada Ki-67 değerleri tümörlerin histolojik dereceleri ile karşılaştırıldı. Ki-67 değerlerinin istatistiksel analizi için ROC analiz yöntemi uygulandı. Bulgular: Merkezimizde meningiom tanılı olgular için ortalama Ki-67 proliferasyon indeks değerleri derece 1 için 6,3, derece 2 için 11,2 ve derece 3 için 26 bulundu. Derece 1 ve derece 2 meningiomların ayrımında histopatolojik bulgulara ek olarak laboratuvarımızda uygulanan Ki-67 proliferasyon indeks pozitiflik sınır değeri 6,5 olarak bulundu p0,05. Sonuç: Menenjiyomda Ki-67 proliferasyon indeksi, özellikle atipik menenjiyomun histolojik derecesini belirlemede kullanılabilecek önemli bir parametredir. İndeks kullanımı kolay gibi görünse de borderline durumlarda ve ayrıca gözlemciler-arası ve gözlemci-içi değerlendirmelerde güçlük yaratabilecek bir değerdir. Bu nedenle her patoloji laboratuvarı menenjiyom derecelendirmesi için sınır olarak kabul edebileceği Ki-67 değerini belirlemelidir.

Makale detayları

Ki-67 Proliferation Index Positivity Limit (Cut-off) Value in Meningiomas

Yazarlar:

Neşe Yeldir | Ezgi Doğan | Hatice Özer | Burçak Söylemez | Serkan Çelikgün | Reyhan Eğilmez

Yayıncı:

Bolu Abant Izzet Baysal University

Ana Başlıklar:

Clinical Sciences

Dergi:

Abant Medical Journal Vol.12 Issue 1, pp.43-50

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001287815

pISSN:

1305-4392

Meningioma

ROC analysis

Positivity limit value (Cut-off value)Meningiom

ROC analizi

Pozitiflik sınır değeri

Sayı

Makale detayları

Ki-67 Proliferation Index Positivity Limit (Cut-off) Value in Meningiomas

Yazarlar: Neşe Yeldir | Ezgi Doğan | Hatice Özer | Burçak Söylemez | Serkan Çelikgün | Reyhan Eğilmez

Yayıncı: Bolu Abant Izzet Baysal University

Ana Başlıklar: Clinical Sciences

Dergi: Abant Medical Journal Vol.12 Issue 1, pp.43-50

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001287815

pISSN: 1305-4392

Meningioma

ROC analysis

Positivity limit value (Cut-off value)Meningiom

ROC analizi

Pozitiflik sınır değeri

Sayı

Yazarlar:

Neşe Yeldir | Ezgi Doğan | Hatice Özer | Burçak Söylemez | Serkan Çelikgün | Reyhan Eğilmez

Yayıncı:

Bolu Abant Izzet Baysal University

Ana Başlıklar:

Clinical Sciences

Dergi:

Abant Medical Journal Vol.12 Issue 1, pp.43-50

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001287815

pISSN:

1305-4392