The Composite Microbeads of Alginate, Carrageenan, Gelatin, and Poly-(Lactic-co-Glycolic Acid): Swelling, Cefaclor Loading and Release

Buse Semerci Arıkan; Demet Baybaş

Makale detayları

The Composite Microbeads of Alginate, Carrageenan, Gelatin, and Poly-(Lactic-co-Glycolic Acid): Swelling, Cefaclor Loading and Release

Yazarlar:

Buse Semerci Arıkan | Demet Baybaş

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

Biyokimya ve Hücre Biyolojisi (Diğer) | Biyomateryaller | Polimer Bilimi ve Teknolojileri

Dergi:

Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi Vol.25 Issue 4, pp.738-756

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001354994

pISSN:

2149-3367

Anahtar kelimeler:

Özet:

 Composite microbeads were synthesized as a combination of two, three, or four of the following components: alginateA, carrageenanC, gelatinG, andor poly lactic-co-glycolic acidP. Herein, CefaclorCef was investigated as a model drug to study the usability of the beads in drug delivery. The composite microspheres with medication and drug-free were synthesized under different conditions. Fourier Transform Infrared FTIR spectra of these composites were compared. The effects of synthesis conditions such as component amounts, cross-linker ion amounts on swelling, entrapment efficiency, and release kinetics of materials were examined. The maximum swelling comparison of the hydrogel composites is A981AP747ACGP641ACG618ACP464AC442AGP295AG157. Adding PLGA to the alginate sphere reduces the swelling contrast adding PLGA to the composite beads containing other components increases the swelling . As the amount of PLGA added to the ACP spheres increases, the swelling decreases. The maximum entrapment efficiency of cefaclor in micro-composites is ACP93AC76AP66ACGAGP46AG40ACGP39A36. All release experiments were carried out in simulated gastric fluid without enzyme at body temperature, with new solutions in a shaking medium. The release of cefaclor from the composite beads did not generally show a burst effect. The selected data fit the first-order release kinetics and the Korsmeyer Peppas and Higuchi drug release models.

 Composite microbeads were synthesized as a combination of two, three, or four of the following components: alginateA, carrageenanC, gelatinG, andor poly lactic-co-glycolic acidP. Herein, CefaclorCef was investigated as a model drug to study the usability of the beads in drug delivery. The composite microspheres with medication and drug-free were synthesized under different conditions. Fourier Transform Infrared FTIR spectra of these composites were compared. The effects of synthesis conditions such as component amounts, cross-linker ion amounts on swelling, entrapment efficiency, and release kinetics of materials were examined. The maximum swelling comparison of the hydrogel composites is A981AP747ACGP641ACG618ACP464AC442AGP295AG157. Adding PLGA to the alginate sphere reduces the swelling contrast adding PLGA to the composite beads containing other components increases the swelling . As the amount of PLGA added to the ACP spheres increases, the swelling decreases. The maximum entrapment efficiency of cefaclor in micro-composites is ACP93AC76AP66ACGAGP46AG40ACGP39A36. All release experiments were carried out in simulated gastric fluid without enzyme at body temperature, with new solutions in a shaking medium. The release of cefaclor from the composite beads did not generally show a burst effect. The selected data fit the first-order release kinetics and the Korsmeyer Peppas and Higuchi drug release models.

 Composite microbeads were synthesized as a combination of two, three, or four of the following components: alginateA, carrageenanC, gelatinG, andor poly lactic-co-glycolic acidP. Herein, CefaclorCef was investigated as a model drug to study the usability of the beads in drug delivery. The composite microspheres with medication and drug-free were synthesized under different conditions. Fourier Transform Infrared FTIR spectra of these composites were compared. The effects of synthesis conditions such as component amounts, cross-linker ion amounts on swelling, entrapment efficiency, and release kinetics of materials were examined. The maximum swelling comparison of the hydrogel composites is A981AP747ACGP641ACG618ACP464AC442AGP295AG157. Adding PLGA to the alginate sphere reduces the swelling contrast adding PLGA to the composite beads containing other components increases the swelling . As the amount of PLGA added to the ACP spheres increases, the swelling decreases. The maximum entrapment efficiency of cefaclor in micro-composites is ACP93AC76AP66ACGAGP46AG40ACGP39A36. All release experiments were carried out in simulated gastric fluid without enzyme at body temperature, with new solutions in a shaking medium. The release of cefaclor from the composite beads did not generally show a burst effect. The selected data fit the first-order release kinetics and the Korsmeyer Peppas and Higuchi drug release models.

 Kompozit mikroboncuklar, aşağıdaki bileşenlerden ikisinin, üçünün veya dördünün bir kombinasyonu olarak sentezlendi: aljinat A, karragenan C, jelatin G veveya poli laktik-ko-glikolik asit P. Burada, ilaç salınımında boncukların kullanılabilirliğini incelemek için model ilaç olarak Sefaklor Cef araştırıldı. İlaçlı ve ilaçsız kompozit mikroküreler farklı koşullar altında sentezlendi. Bu kompozitlerin Fourier Dönüşümlü Kızılötesi FTIR spektrumları karşılaştırıldı. Bileşen miktarları, çapraz bağlayıcı iyon miktarları gibi sentez koşullarının şişme, tutulma verimliliği ve malzemelerin salım kinetiği üzerindeki etkileri incelendi. Hidrojel kompozitlerinin maksimum şişme karşılaştırması A981AP747ACGP641ACG618ACP464AC442AGP295AG157 şeklindedir. Aljinat küresine PLGA eklenmesi şişme kontrastını azaltırken, diğer bileşenleri içeren kompozit boncuklara PLGA eklenmesi şişme sini artırır. ACP kürelerine eklenen PLGA miktarı arttıkça şişme azalır. Sefaklorun mikro kompozitlerdeki maksimum tutulma etkinliği ACP93AC76AP66ACGAGP46AG40ACGP39A36dır. Tüm salım deneyleri, çalkalama ortamında yeni çözeltilerle, vücut sıcaklığında enzimsiz simüle edilmiş mide sıvısında gerçekleştirildi. Sefaklorun kompozit boncuklardan salımında genellikle bir patlama etkisi görülmedi. Seçilen veriler birinci dereceden salım kinetiğine ve Korsmeyer Peppas ve Higuchi ilaç salım modellerine uymaktadır.

Makale detayları

The Composite Microbeads of Alginate, Carrageenan, Gelatin, and Poly-(Lactic-co-Glycolic Acid): Swelling, Cefaclor Loading and Release

Yazarlar:

Buse Semerci Arıkan | Demet Baybaş

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

Biyokimya ve Hücre Biyolojisi (Diğer) | Biyomateryaller | Polimer Bilimi ve Teknolojileri

Dergi:

Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi Vol.25 Issue 4, pp.738-756

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001354994

pISSN:

2149-3367

cefaklor release

alginate

carrageenan

gelatin

poly(lactic-co-glycolic acid)sefaklor salınımı,

aljinat,

karragenan,

jelatin,

poli(laktik-ko-glikolik asit)

Sayı

Makale detayları

Yazarlar: Buse Semerci Arıkan | Demet Baybaş

Yayıncı: Afyon Kocatepe University

Ana Başlıklar: Biyokimya ve Hücre Biyolojisi (Diğer) | Biyomateryaller | Polimer Bilimi ve Teknolojileri

Dergi: Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi Vol.25 Issue 4, pp.738-756

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001354994

pISSN: 2149-3367

Sayı

Yazarlar:

Buse Semerci Arıkan | Demet Baybaş

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

Biyokimya ve Hücre Biyolojisi (Diğer) | Biyomateryaller | Polimer Bilimi ve Teknolojileri

Dergi:

Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi Vol.25 Issue 4, pp.738-756

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001354994

pISSN:

2149-3367