Molecular Docking Study of Four Chromene Derivatives as Novel HIV-1 Integrase Inhibitors

Nevin ARSLAN

doi:https://doi.org/10.18596/jotcsa.478772

Makale detayları

Molecular Docking Study of Four Chromene Derivatives as Novel HIV-1 Integrase Inhibitors

Yazarlar:

Nevin ARSLAN

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry 2019 Vol.6 Issue 2, pp.133-142

Belge Tipi:

Makale

Yayın Tarihi:

6/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000502842

Sıklık:

Üç Aylık

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.478772

Özet:

 


Four ligands based on chromene derivatives have been docked into integrase of prototype foamy virus, which has a quite similar structural similarity with that of HIV-1 integrase using Autodock Vina (Vina). The docking scores for the derivatives are -7.3 kcal/mol, -7.5 kcal/mol, -6.9 kcal/mol, and -7.2 kcal/mol, respectively, which are comparable with that for Raltegravir (-10.7 kcal/mol). The docking results provide a detailed evidence for the interactions of four chromene derivatives. The results may lead to the design and development of new drug candidates against AIDS


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Makale detayları

Molecular Docking Study of Four Chromene Derivatives as Novel HIV-1 Integrase Inhibitors

Yazarlar: Nevin ARSLAN

Yayıncı: Turkish Chemical Society

Ana Başlıklar: Kimya ve ilgili bilimler

Dergi: Journal of the Turkish Chemical Society Section A: Chemistry 2019 Vol.6 Issue 2, pp.133-142

Belge Tipi: Makale

Yayın Tarihi: 6/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000502842

Sıklık: Üç Aylık

eISSN: 2149-0120

DOI: https://doi.org/10.18596/jotcsa.478772

Sayı

Yazarlar:

Nevin ARSLAN

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Kimya ve ilgili bilimler

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry 2019 Vol.6 Issue 2, pp.133-142

Belge Tipi:

Makale

Yayın Tarihi:

6/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000502842

Sıklık:

Üç Aylık

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.478772