Formulation development and evaluation of carbopol-incorporated mucoadhesive thermoreversible gels of sucralfate for rectal drug delivery

Firoz SHAIK; Rajasekaran S

doi:https://doi.org/10.52794/hujpharm.1012883

Makale detayları

Formulation development and evaluation of carbopol-incorporated mucoadhesive thermoreversible gels of sucralfate for rectal drug delivery

Yazarlar:

Firoz SHAIK | Rajasekaran S

Yayıncı:

Hacettepe University

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy 2021 Vol.41 Issue 4, pp.234-242

Belge Tipi:

Makale

Yayın Tarihi:

11/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000454278

Sıklık:

Üç Aylık

eISSN:

2458-8806

DOI:

https://doi.org/10.52794/hujpharm.1012883

Özet:

 

Objective : The present study describes the preparation and evaluation of a Poloxamer 188 (P188)-based thermoreversible gel using Carbopol 934P (C934P) as a mucoadhesive polymer of Sucralfate for enhancing the bioavailability and to avoid the first-pass metabolism. Methods: Eight formulations (F1-F8) were prepared using cold method. The prepared gels were characterized by pH, drug content, spreadability, mucoadhesive force, gelation temperature, and drug release profile. Thermoreversibility of P188/C934P gel was demonstrated by rheological studies. The drug-polymer compatibility was studied using Fourier transform infrared (FTIR). The incorporation of carbopol into P188 gel also reduced the amounts of drug released from the gel formulations. 
Results: FT-IR studies revealed that there are no interactions between the drug and polymers. Drug content of gels was estimated and the results were found to be satisfactory. In vitro dissolution studies revealed a good drug release from the gels. The drug release was higher in formulations F5 and F6 and lower in F4, F7, and F8 formulations. These findings suggested that developed thermoreversible gels could be used as promising dosage forms to rectal drug delivery for prolonged periods in the management of hemorrhoids.

Makale detayları

Formulation development and evaluation of carbopol-incorporated mucoadhesive thermoreversible gels of sucralfate for rectal drug delivery

Yazarlar: Firoz SHAIK | Rajasekaran S

Yayıncı: Hacettepe University

Ana Başlıklar: Farmakoloji ve terapötik

Dergi: Hacettepe University Journal of the Faculty of Pharmacy 2021 Vol.41 Issue 4, pp.234-242

Belge Tipi: Makale

Yayın Tarihi: 11/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000454278

Sıklık: Üç Aylık

eISSN: 2458-8806

DOI: https://doi.org/10.52794/hujpharm.1012883

Sayı

Yazarlar:

Firoz SHAIK | Rajasekaran S

Yayıncı:

Hacettepe University

Ana Başlıklar:

Farmakoloji ve terapötik

Dergi:

Hacettepe University Journal of the Faculty of Pharmacy 2021 Vol.41 Issue 4, pp.234-242

Belge Tipi:

Makale

Yayın Tarihi:

11/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000454278

Sıklık:

Üç Aylık

eISSN:

2458-8806

DOI:

https://doi.org/10.52794/hujpharm.1012883