Development of biosynthesized silver nanoparticles from Cinnamomum tamala for anti-oxidant, anti-microbial and anti-cancer activity

Laxman Vıjapur; Y Srinivas; Anita Desai; Somalingeshwar Siddramshettar

Makale detayları

Development of biosynthesized silver nanoparticles from Cinnamomum tamala for anti-oxidant, anti-microbial and anti-cancer activity

Yazarlar:

Laxman Vıjapur | Y Srinivas | Anita Desai | Somalingeshwar Siddramshettar

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 2, pp.769-782

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347839

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Purpose: The purpose of this study was to determine the effect of biosynthesized silver nanoparticles AgNPs from Cinnamomum tamala aqueous extract CTAE for antioxidant, antimicrobial and anticancer activity. Experimental approach: Biosynthesis of AgNPs was successfully achieved by using CTAE by eco-friendly and a cheaper method. In this study we used CTAE for biosynthesis, which reduces silver ions into AgNPs. The obtained AgNPs were characterized by UV, FTIR, DLS, TEM and EDAX analysis. They were further analyzed for their anti- oxidant, anti-microbial, anti-cancer activities. Key results: The presence of biosynthesized AgNPs 422nm was confirmed by UV-visible spectroscopy. FT-IR spectrum was used to confirm the presence of different functional groups in the biomolecules which were responsible for capping  reducing of the nanoparticles. Dynamic light scattering of the prepared formulations revealed all the formulations were in nano- range, F1 showed the mean particle size 239.1nm.TEM Analysis revealed that the size of the particleswere in nano-range of 20.38nm and presence of silver was confirmed through EDAX. The IC50 value of F1 indicated 91.30µgml for H2O2 scavenging activity and 102.43µgml for DPPH scavenging activity. Biosynthesized AgNPs F1 showed good antimicrobial activity against two gram negative bacteria and one gram positive bacteria. MTT assay of optimized formulation F1 was compared with CTAE showed significant antiproliferative activity against A375 cancer cell line with IC50 for CTAE was 47.24µgml, where as for biosynthesized AgNPs the IC50 was 22µgml. Apoptosis studies of formulation F1 showed higher early apoptosis as compared to CTAE. Conclusion: The biosynthesized silver nanoparticles F1 showed good antioxidant activity, antimicrobial activity and anti cancer activity compared to CTAE.

 Purpose: The purpose of this study was to determine the effect of biosynthesized silver nanoparticles AgNPs from Cinnamomum tamala aqueous extract CTAE for antioxidant, antimicrobial and anticancer activity. Experimental approach: Biosynthesis of AgNPs was successfully achieved by using CTAE by eco-friendly and a cheaper method. In this study we used CTAE for biosynthesis, which reduces silver ions into AgNPs. The obtained AgNPs were characterized by UV, FTIR, DLS, TEM and EDAX analysis. They were further analyzed for their anti- oxidant, anti-microbial, anti-cancer activities. Key results: The presence of biosynthesized AgNPs 422nm was confirmed by UV-visible spectroscopy. FT-IR spectrum was used to confirm the presence of different functional groups in the biomolecules which were responsible for capping  reducing of the nanoparticles. Dynamic light scattering of the prepared formulations revealed all the formulations were in nano- range, F1 showed the mean particle size 239.1nm.TEM Analysis revealed that the size of the particleswere in nano-range of 20.38nm and presence of silver was confirmed through EDAX. The IC50 value of F1 indicated 91.30µgml for H2O2 scavenging activity and 102.43µgml for DPPH scavenging activity. Biosynthesized AgNPs F1 showed good antimicrobial activity against two gram negative bacteria and one gram positive bacteria. MTT assay of optimized formulation F1 was compared with CTAE showed significant antiproliferative activity against A375 cancer cell line with IC50 for CTAE was 47.24µgml, where as for biosynthesized AgNPs the IC50 was 22µgml. Apoptosis studies of formulation F1 showed higher early apoptosis as compared to CTAE. Conclusion: The biosynthesized silver nanoparticles F1 showed good antioxidant activity, antimicrobial activity and anti cancer activity compared to CTAE.

 Purpose: The purpose of this study was to determine the effect of biosynthesized silver nanoparticles AgNPs from Cinnamomum tamala aqueous extract CTAE for antioxidant, antimicrobial and anticancer activity. Experimental approach: Biosynthesis of AgNPs was successfully achieved by using CTAE by eco-friendly and a cheaper method. In this study we used CTAE for biosynthesis, which reduces silver ions into AgNPs. The obtained AgNPs were characterized by UV, FTIR, DLS, TEM and EDAX analysis. They were further analyzed for their anti- oxidant, anti-microbial, anti-cancer activities. Key results: The presence of biosynthesized AgNPs 422nm was confirmed by UV-visible spectroscopy. FT-IR spectrum was used to confirm the presence of different functional groups in the biomolecules which were responsible for capping  reducing of the nanoparticles. Dynamic light scattering of the prepared formulations revealed all the formulations were in nano- range, F1 showed the mean particle size 239.1nm.TEM Analysis revealed that the size of the particleswere in nano-range of 20.38nm and presence of silver was confirmed through EDAX. The IC50 value of F1 indicated 91.30µgml for H2O2 scavenging activity and 102.43µgml for DPPH scavenging activity. Biosynthesized AgNPs F1 showed good antimicrobial activity against two gram negative bacteria and one gram positive bacteria. MTT assay of optimized formulation F1 was compared with CTAE showed significant antiproliferative activity against A375 cancer cell line with IC50 for CTAE was 47.24µgml, where as for biosynthesized AgNPs the IC50 was 22µgml. Apoptosis studies of formulation F1 showed higher early apoptosis as compared to CTAE. Conclusion: The biosynthesized silver nanoparticles F1 showed good antioxidant activity, antimicrobial activity and anti cancer activity compared to CTAE.

 Purpose: The purpose of this study was to determine the effect of biosynthesized silver nanoparticles AgNPs from Cinnamomum tamala aqueous extract CTAE for antioxidant, antimicrobial and anticancer activity. Experimental approach: Biosynthesis of AgNPs was successfully achieved by using CTAE by eco-friendly and a cheaper method. In this study we used CTAE for biosynthesis, which reduces silver ions into AgNPs. The obtained AgNPs were characterized by UV, FTIR, DLS, TEM and EDAX analysis. They were further analyzed for their anti- oxidant, anti-microbial, anti-cancer activities. Key results: The presence of biosynthesized AgNPs 422nm was confirmed by UV-visible spectroscopy. FT-IR spectrum was used to confirm the presence of different functional groups in the biomolecules which were responsible for capping  reducing of the nanoparticles. Dynamic light scattering of the prepared formulations revealed all the formulations were in nano- range, F1 showed the mean particle size 239.1nm.TEM Analysis revealed that the size of the particleswere in nano-range of 20.38nm and presence of silver was confirmed through EDAX. The IC50 value of F1 indicated 91.30µgml for H2O2 scavenging activity and 102.43µgml for DPPH scavenging activity. Biosynthesized AgNPs F1 showed good antimicrobial activity against two gram negative bacteria and one gram positive bacteria. MTT assay of optimized formulation F1 was compared with CTAE showed significant antiproliferative activity against A375 cancer cell line with IC50 for CTAE was 47.24µgml, where as for biosynthesized AgNPs the IC50 was 22µgml. Apoptosis studies of formulation F1 showed higher early apoptosis as compared to CTAE. Conclusion: The biosynthesized silver nanoparticles F1 showed good antioxidant activity, antimicrobial activity and anti cancer activity compared to CTAE.

Makale detayları

Development of biosynthesized silver nanoparticles from Cinnamomum tamala for anti-oxidant, anti-microbial and anti-cancer activity

Yazarlar:

Laxman Vıjapur | Y Srinivas | Anita Desai | Somalingeshwar Siddramshettar

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 2, pp.769-782

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347839

pISSN:

2630-6344

Cinnamomum tamala

Silver nitrate

Silver nanoparticles

Anticancer activity

Anti-microbial activity

Anti-oxidant activity

Sayı

Makale detayları

Development of biosynthesized silver nanoparticles from Cinnamomum tamala for anti-oxidant, anti-microbial and anti-cancer activity

Yazarlar: Laxman Vıjapur | Y Srinivas | Anita Desai | Somalingeshwar Siddramshettar

Yayıncı: Marmara University

Ana Başlıklar: Pharmacognosy

Dergi: Journal of Research in Pharmacy Vol.27 Issue 2, pp.769-782

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347839

pISSN: 2630-6344

Cinnamomum tamala

Silver nitrate

Silver nanoparticles

Anticancer activity

Anti-microbial activity

Anti-oxidant activity

Sayı

Yazarlar:

Laxman Vıjapur | Y Srinivas | Anita Desai | Somalingeshwar Siddramshettar

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacognosy

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 2, pp.769-782

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347839

pISSN:

2630-6344