The Relationship of ABO and Rh Blood Group Antigens with Mortality in Clinical and Intensive Care Patients with a Diagnosis of COVID-19: A Pandemic Hospital Experience

Serra Topal; Gülbahar Çalışkan; Ayça Sayan; Nermin Kelebek Girgin

Makale detayları

The Relationship of ABO and Rh Blood Group Antigens with Mortality in Clinical and Intensive Care Patients with a Diagnosis of COVID-19: A Pandemic Hospital Experience

Yazarlar:

Serra Topal | Gülbahar Çalışkan | Ayça Sayan | Nermin Kelebek Girgin

Yayıncı:

Manisa Celal Bayar University

Ana Başlıklar:

Yoğun Bakım

Dergi:

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.10 Issue 1, pp.7-14

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001287131

pISSN:

2147-9607

Anahtar kelimeler:

Özet:

 Objective: Coronavirus 2019COVID-19 has caused a pandemic that affects many people all over the world with high mortality.ABO blood groups are associated with many chronic diseases such as vascular and coronary heart diseases,as well as viral infections.In this study,we aimed to investigate the relationship of blood groups with susceptibility to COVID-19 and mortality. Materials and Methods: Between 17 March 2020 and 30 November 2020,the files of adult patients that were hospitalized with the diagnosis of PCR positive COVID-19 in our hospital were reviewed retrospectively.Demographic data,distribution rates of ABO and Rh blood groups were recorded.The effect of blood groups on mortality was analyzed.The patients were grouped according to the presence of anti-AB and O blood groupsor absenceA and AB blood groups in their serum and compared in terms of age,gender,intensive care unitICUadmission, and mortality. Results: 3137 patients were included in the study.Of the patients,2231 were hospitalized in the wards and 906 in the ICU.The patients were median 57 years old,51.2 of them were male.Most of ICU patients were male genderp0.001.The rates of having A,B,AB, and O blood groups of the patients were respectively 47.5,14.5,8.3, and 29.6.Treatment of 530 patients resulted in death.Age affected mortality in clinical and ICU patientsp 0.000 for both.While male gender mortality61.9 was significantly higher in all patientsp0.001.The presence of Rh and anti-A isohemagglutinin in the serum wasnt associated with mortalityp0.42,p 0.565.As a result of multivariate logistic regression analysis, blood group wasnt found to be associated with mortality. Age, male gender, and need for mechanical ventilation were found to be independent risk factors for mortalityRespectively.1.073 p0.001,OR.1.580 p0.001,OR.40.061p0.001. Conclusion: In our study,no difference was found in the ABO blood group distributions of the patients followed both clinic and in the ICU.Mortality was higher in the AB blood group.Future studies are needed to show the relationship between ABO blood groups and SARS-CoV-2 infection.

 Objective: Coronavirus 2019COVID-19 has caused a pandemic that affects many people all over the world with high mortality.ABO blood groups are associated with many chronic diseases such as vascular and coronary heart diseases,as well as viral infections.In this study,we aimed to investigate the relationship of blood groups with susceptibility to COVID-19 and mortality. Materials and Methods: Between 17 March 2020 and 30 November 2020,the files of adult patients that were hospitalized with the diagnosis of PCR positive COVID-19 in our hospital were reviewed retrospectively.Demographic data,distribution rates of ABO and Rh blood groups were recorded.The effect of blood groups on mortality was analyzed.The patients were grouped according to the presence of anti-AB and O blood groupsor absenceA and AB blood groups in their serum and compared in terms of age,gender,intensive care unitICUadmission, and mortality. Results: 3137 patients were included in the study.Of the patients,2231 were hospitalized in the wards and 906 in the ICU.The patients were median 57 years old,51.2 of them were male.Most of ICU patients were male genderp0.001.The rates of having A,B,AB, and O blood groups of the patients were respectively 47.5,14.5,8.3, and 29.6.Treatment of 530 patients resulted in death.Age affected mortality in clinical and ICU patientsp 0.000 for both.While male gender mortality61.9 was significantly higher in all patientsp0.001.The presence of Rh and anti-A isohemagglutinin in the serum wasnt associated with mortalityp0.42,p 0.565.As a result of multivariate logistic regression analysis, blood group wasnt found to be associated with mortality. Age, male gender, and need for mechanical ventilation were found to be independent risk factors for mortalityRespectively.1.073 p0.001,OR.1.580 p0.001,OR.40.061p0.001. Conclusion: In our study,no difference was found in the ABO blood group distributions of the patients followed both clinic and in the ICU.Mortality was higher in the AB blood group.Future studies are needed to show the relationship between ABO blood groups and SARS-CoV-2 infection.

 Objective: Coronavirus 2019COVID-19 has caused a pandemic that affects many people all over the world with high mortality.ABO blood groups are associated with many chronic diseases such as vascular and coronary heart diseases,as well as viral infections.In this study,we aimed to investigate the relationship of blood groups with susceptibility to COVID-19 and mortality. Materials and Methods: Between 17 March 2020 and 30 November 2020,the files of adult patients that were hospitalized with the diagnosis of PCR positive COVID-19 in our hospital were reviewed retrospectively.Demographic data,distribution rates of ABO and Rh blood groups were recorded.The effect of blood groups on mortality was analyzed.The patients were grouped according to the presence of anti-AB and O blood groupsor absenceA and AB blood groups in their serum and compared in terms of age,gender,intensive care unitICUadmission, and mortality. Results: 3137 patients were included in the study.Of the patients,2231 were hospitalized in the wards and 906 in the ICU.The patients were median 57 years old,51.2 of them were male.Most of ICU patients were male genderp0.001.The rates of having A,B,AB, and O blood groups of the patients were respectively 47.5,14.5,8.3, and 29.6.Treatment of 530 patients resulted in death.Age affected mortality in clinical and ICU patientsp 0.000 for both.While male gender mortality61.9 was significantly higher in all patientsp0.001.The presence of Rh and anti-A isohemagglutinin in the serum wasnt associated with mortalityp0.42,p 0.565.As a result of multivariate logistic regression analysis, blood group wasnt found to be associated with mortality. Age, male gender, and need for mechanical ventilation were found to be independent risk factors for mortalityRespectively.1.073 p0.001,OR.1.580 p0.001,OR.40.061p0.001. Conclusion: In our study,no difference was found in the ABO blood group distributions of the patients followed both clinic and in the ICU.Mortality was higher in the AB blood group.Future studies are needed to show the relationship between ABO blood groups and SARS-CoV-2 infection.

 Giriş ve Amaç: Coronovirus 2019 COVID-19 tüm dünyada pek çok kişiyi etkileyen ve mortalitesi yüksek olan pandemiye neden olmuştur. ABO kan grupları vasküler, koroner kalp hastalıkları gibi birçok kronik hastalık yanında viral enfeksiyonlarla da ilişkilendirilmektedir.Bu çalışmada kan gruplarının COVID-19a yatkınlık ve mortalite ile ilşkisini araştırmayı amaçladık. Gereç ve Yöntemler: 17 Mart 2020 ve 30 Kasım 2020 tarihleri arasında PCR pozitif COVID-19 tanısı ile hastanemizde yatırılarak tedavi edilen erişkin hastaların dosyaları retrospektif olarak incelendi. Demografik veriler, ABO ve Rh kan gruplarının dağılım oranları kaydedildi. Kan gruplarının mortaliteye etkisi incelendi. Hastalar serumlarında anti-A bulunması B ve O kan grubu ve bulunmamasına A ve AB kan grubu göre gruplandırılarak yaş, cinsiyet, yoğun bakıma YB yatış ve mortalite açısından karşılaştırıldı. Bulgular: Çalışmaya 3137 hasta dahil edildi. Hastaların 2231i kliniğe, 906sı YBye yatırılmıştı. Hastalar 55.1717.90 yaşında olup, 51.2si erkek idi. Hastaların A, B, AB ve O kan grubuna sahip olma oranları sırasıyla 47.5, 14.5, 8.3 ve 29.6 idi. Hastaların 530nun tedavisi eksitus ile sonuçlanmıştı. Yaş, klinik ve YB hastalarında mortaliteyi etkilemişti ikisi için p0.000. Tüm hastalarda erkek cinsiyette mortalite 61.9 anlamlı olarak yüksekti p0.000. Rhın ve serumda anti-A izohemaglütinin bulunmasının mortalite ile ilişkisi yoktu p0.42, p0.565. Multivariate lojistik regresyon analizi sonucu kan grubu mortalite ile ilişkili tespit edilmedi. Yaş, erkek cinsiyet ve mekanik ventilasyon gereksinimi mortalite için bağımsız risk faktörü olarak saptandı sırasıyla OR.1.073p0.001, OR.1.580p0.001, OR.40.061p0.001. Sonuç: Çalışmamızda hem klinik hem YBde takip edilen hastaların ABO kan grubu dağılımlarında fark saptanmadı. Mortalite, AB kan grubunda yüksekti. ABO kan grupları ile SARS-CoV-2 enfeksiyonu arasındaki ilişkinin gösterilmesi için gelecek çalışmalara ihtiyaç vardır.

Makale detayları

The Relationship of ABO and Rh Blood Group Antigens with Mortality in Clinical and Intensive Care Patients with a Diagnosis of COVID-19: A Pandemic Hospital Experience

Yazarlar:

Serra Topal | Gülbahar Çalışkan | Ayça Sayan | Nermin Kelebek Girgin

Yayıncı:

Manisa Celal Bayar University

Ana Başlıklar:

Yoğun Bakım

Dergi:

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.10 Issue 1, pp.7-14

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001287131

pISSN:

2147-9607

ABO blood group

Rh blood group

COVID-19

mortality

ABO kan grubu

Rh kan grubu

COVID-19

mortalite

Sayı

Makale detayları

Yazarlar: Serra Topal | Gülbahar Çalışkan | Ayça Sayan | Nermin Kelebek Girgin

Yayıncı: Manisa Celal Bayar University

Ana Başlıklar: Yoğun Bakım

Dergi: Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.10 Issue 1, pp.7-14

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001287131

pISSN: 2147-9607

Sayı

Yazarlar:

Serra Topal | Gülbahar Çalışkan | Ayça Sayan | Nermin Kelebek Girgin

Yayıncı:

Manisa Celal Bayar University

Ana Başlıklar:

Yoğun Bakım

Dergi:

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.10 Issue 1, pp.7-14

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001287131

pISSN:

2147-9607