Antioxidant and Antihyperlipidemic Effect of Solanum Nigrum Extract in Experimental Diabetes Model

Ahmet Cihat Öner; Fatmagül Yur; Mohammed Nooraddin Fethullah

Makale detayları

Antioxidant and Antihyperlipidemic Effect of Solanum Nigrum Extract in Experimental Diabetes Model

Yazarlar:

Ahmet Cihat Öner | Fatmagül Yur | Mohammed Nooraddin Fethullah

Yayıncı:

Van Yuzuncu Yıl University

Ana Başlıklar:

Veteriner Cerrahi

Dergi:

Van Veterinary Journal Vol.34 Issue 3, pp.184-188

Belge Tipi:

Makale

Yayın Tarihi:

11/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001304283

pISSN:

2149-3359

Anahtar kelimeler:

Özet:

 Diabetes mellitus DM is a chronic metabolic non-communicable disease; it is globally considered the fifth cause of death and it has attained worldwide epidemic proportions. In our study, we aimed to investigate the diabetic effects of Solanum nigrum extract using the control group C, diabetes group D, groups given the Solanum nigrum extract SN and diabetes group  Solanum nigrum extract DSN. Our results observed the biological effectiveness of Solanum nigrum extract on glucose levels, significant increase serum glucose level group D 66321.8 mgdL in comparison with C 1319.8 mgdL were recorded. However, there were no significant difference in glucose level between C group 1319.8 mgdl and SN group 196.1412.1 mgdL. Moreover, glucose level of DSN group 484.840.0 mgdL was significantly higher than C 1319.8 mgdl, D 66321.8 mgdl and SN groups 196.1412.1 mgdL. Total antioxidant status TAS level in D group 1.850.15.7 was significant when compared C group 1.280.17. Significant differences were observed between D group and DSN group 1.540.07. However, TAS levels showed no significant difference in both SN 1.270.10 and DSN 1.540.07 groups in comparison to the control group. Total oxidant status TOS level in D group 6.301.41 was given significant differences in comparison with control C 3.870.34, SN 4.870.80 group and DSN 4.140.34 groups. In contrary, there were no significant differences between all of C, SN, DSN groups. As a result, we can say that the Solanum nigrum plant extract is effective on diabetes, but it cannot lower the glucose level to normal levels, it needs to be investigated in future studies and its effects at different doses by different extraction methods.

 Diabetes mellitus DM is a chronic metabolic non-communicable disease; it is globally considered the fifth cause of death and it has attained worldwide epidemic proportions. In our study, we aimed to investigate the diabetic effects of Solanum nigrum extract using the control group C, diabetes group D, groups given the Solanum nigrum extract SN and diabetes group  Solanum nigrum extract DSN. Our results observed the biological effectiveness of Solanum nigrum extract on glucose levels, significant increase serum glucose level group D 66321.8 mgdL in comparison with C 1319.8 mgdL were recorded. However, there were no significant difference in glucose level between C group 1319.8 mgdl and SN group 196.1412.1 mgdL. Moreover, glucose level of DSN group 484.840.0 mgdL was significantly higher than C 1319.8 mgdl, D 66321.8 mgdl and SN groups 196.1412.1 mgdL. Total antioxidant status TAS level in D group 1.850.15.7 was significant when compared C group 1.280.17. Significant differences were observed between D group and DSN group 1.540.07. However, TAS levels showed no significant difference in both SN 1.270.10 and DSN 1.540.07 groups in comparison to the control group. Total oxidant status TOS level in D group 6.301.41 was given significant differences in comparison with control C 3.870.34, SN 4.870.80 group and DSN 4.140.34 groups. In contrary, there were no significant differences between all of C, SN, DSN groups. As a result, we can say that the Solanum nigrum plant extract is effective on diabetes, but it cannot lower the glucose level to normal levels, it needs to be investigated in future studies and its effects at different doses by different extraction methods.

 Diabetes mellitus DM is a chronic metabolic non-communicable disease; it is globally considered the fifth cause of death and it has attained worldwide epidemic proportions. In our study, we aimed to investigate the diabetic effects of Solanum nigrum extract using the control group C, diabetes group D, groups given the Solanum nigrum extract SN and diabetes group  Solanum nigrum extract DSN. Our results observed the biological effectiveness of Solanum nigrum extract on glucose levels, significant increase serum glucose level group D 66321.8 mgdL in comparison with C 1319.8 mgdL were recorded. However, there were no significant difference in glucose level between C group 1319.8 mgdl and SN group 196.1412.1 mgdL. Moreover, glucose level of DSN group 484.840.0 mgdL was significantly higher than C 1319.8 mgdl, D 66321.8 mgdl and SN groups 196.1412.1 mgdL. Total antioxidant status TAS level in D group 1.850.15.7 was significant when compared C group 1.280.17. Significant differences were observed between D group and DSN group 1.540.07. However, TAS levels showed no significant difference in both SN 1.270.10 and DSN 1.540.07 groups in comparison to the control group. Total oxidant status TOS level in D group 6.301.41 was given significant differences in comparison with control C 3.870.34, SN 4.870.80 group and DSN 4.140.34 groups. In contrary, there were no significant differences between all of C, SN, DSN groups. As a result, we can say that the Solanum nigrum plant extract is effective on diabetes, but it cannot lower the glucose level to normal levels, it needs to be investigated in future studies and its effects at different doses by different extraction methods.

 Diabetes mellitus DM, kronik, metabolik, bulaşıcı olmayan bir hastalıktır, dünya çapında beşinci ölüm nedeni olarak kabul edilir ve dünya çapında epidemik oranlara ulaşmıştır. Çalışmamızda kontrol grubu K, diyabet grubu D, Solanum nigrum özü SN ve diyabet  Solanum nigrum özü DSN verilen gruplar kullanılarak Solanum nigrum ekstraktının diyabetik etkilerini araştırmayı amaçladık. Sonuçlarımız, Solanum nigrum ekstraktının glukoz seviyeleri üzerinde biyolojik etkinliği gözlenirken, serum glukoz seviyesinde D 66321.8 mgdL Cye 1319.8 mgdL kıyasla anlamlı artış kaydedildi. Ancak C grubu 1319.8 mgdl ve SN grubu 196.1412.1 mgdL arasında glukoz düzeyi açısından anlamlı fark yoktu. Ayrıca D  SN grubunun glukoz düzeyi 484.840.0 mgdL, C 1319.8 mgdl, D 66321.8 mgdl ve SN gruplarına 196.1412.1 mgdL göre anlamlı olarak yüksekti. D grubunda 1,850,15,7 toplam antioksidan durum TAS düzeyi, C grubu 1.280.17 ile karşılaştırıldığında anlamlıydı. D grubu ile DSN grubu arasında anlamlı farklar gözlendi 154007. Ancak TAS düzeyleri hem SN 1.270.10 hem de DSN 1.540.07 gruplarında kontrole göre anlamlı farklılık göstermedi. D grubunda 6.301.41 toplam oksidan durum TOS düzeyi, kontrol C 3.870.34, SN 4.870,80 grubu ve DSN 4.140.34 gruplarına göre anlamlı farklılık gösterdi. Aksine, tüm C, SN, DSN grupları arasında anlamlı bir fark yoktu. Sonuç olarak Solanum nigrum bitki ekstraktının diyabet üzerinde etkili olduğunu ancak glikoz seviyesini normal seviyelere indiremediğini, farklı dozlarda ve farklı ekstraksiyon yöntemleri ile etkilerinin ileriki çalışmalarda araştırılması gerektiğini söyleyebiliriz.

Makale detayları

Antioxidant and Antihyperlipidemic Effect of Solanum Nigrum Extract in Experimental Diabetes Model

Yazarlar:

Ahmet Cihat Öner | Fatmagül Yur | Mohammed Nooraddin Fethullah

Yayıncı:

Van Yuzuncu Yıl University

Ana Başlıklar:

Veteriner Cerrahi

Dergi:

Van Veterinary Journal Vol.34 Issue 3, pp.184-188

Belge Tipi:

Makale

Yayın Tarihi:

11/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001304283

pISSN:

2149-3359

Hypolipidemica agent

Streptozocin

Oxidative stressHipolipidemik ajan

Oksidatif stres

Streptozosin

Sayı

Makale detayları

Antioxidant and Antihyperlipidemic Effect of Solanum Nigrum Extract in Experimental Diabetes Model

Yazarlar: Ahmet Cihat Öner | Fatmagül Yur | Mohammed Nooraddin Fethullah

Yayıncı: Van Yuzuncu Yıl University

Ana Başlıklar: Veteriner Cerrahi

Dergi: Van Veterinary Journal Vol.34 Issue 3, pp.184-188

Belge Tipi: Makale

Yayın Tarihi: 11/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001304283

pISSN: 2149-3359

Hypolipidemica agent

Streptozocin

Oxidative stressHipolipidemik ajan

Oksidatif stres

Streptozosin

Sayı

Yazarlar:

Ahmet Cihat Öner | Fatmagül Yur | Mohammed Nooraddin Fethullah

Yayıncı:

Van Yuzuncu Yıl University

Ana Başlıklar:

Veteriner Cerrahi

Dergi:

Van Veterinary Journal Vol.34 Issue 3, pp.184-188

Belge Tipi:

Makale

Yayın Tarihi:

11/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001304283

pISSN:

2149-3359