Cytotoxic and Antitumor Potential of Fagonia cretica L.

Ahsan HUSSAIN; Muhammad ZIA; Bushra MIRZA

Makale detayları

Cytotoxic and Antitumor Potential of Fagonia cretica L.

Yazarlar:

Ahsan HUSSAIN | Muhammad ZIA | Bushra MIRZA

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2007 Vol.31 Issue 1, pp.19-24

Belge Tipi:

Makale

Yayın Tarihi:

12/2006

Belge Dili:

Türkçe

Document ID (Org No.):

2000813314

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152

Anahtar kelimeler:

Özet:

 

According to traditional knowledge, Fagonia cretica has medicinal potential, especially against cancer and tumors. In the present study, this information was analyzed at laboratory level by performing cytotoxic, antitumor (potato disc) and DNA damage assay. Significant cytotoxic activity was found against brine shrimps at LD50 118.89 ppm, while antitumor assay showed that the extract inhibited tumor induction on potato discs. Significant antitumor activity was found against all the tumor-inducing Agrobacterium strains tested (At6, At10 and At77), with maximum tumor inhibition (77.04%) against At10. However, the extract did not show any lethal activity against Agrobacterium tumefaciens strains, and furthermore, no DNA damaging activity was observed. The overall results indicate a strong anti-cancerous potential of this plant.

 

According to traditional knowledge, Fagonia cretica has medicinal potential, especially against cancer and tumors. In the present study, this information was analyzed at laboratory level by performing cytotoxic, antitumor (potato disc) and DNA damage assay. Significant cytotoxic activity was found against brine shrimps at LD50 118.89 ppm, while antitumor assay showed that the extract inhibited tumor induction on potato discs. Significant antitumor activity was found against all the tumor-inducing Agrobacterium strains tested (At6, At10 and At77), with maximum tumor inhibition (77.04%) against At10. However, the extract did not show any lethal activity against Agrobacterium tumefaciens strains, and furthermore, no DNA damaging activity was observed. The overall results indicate a strong anti-cancerous potential of this plant.

Makale detayları

Cytotoxic and Antitumor Potential of Fagonia cretica L.

Yazarlar:

Ahsan HUSSAIN | Muhammad ZIA | Bushra MIRZA

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2007 Vol.31 Issue 1, pp.19-24

Belge Tipi:

Makale

Yayın Tarihi:

12/2006

Belge Dili:

Türkçe

Document ID (Org No.):

2000813314

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152

Fagonia cretica L

cytotoxic activity

potato disc assay

mutagenic activity

Sayı

Makale detayları

Cytotoxic and Antitumor Potential of Fagonia cretica L.

Yazarlar: Ahsan HUSSAIN | Muhammad ZIA | Bushra MIRZA

Yayıncı: TUBITAK

Dergi: Turkish Journal of Biology 2007 Vol.31 Issue 1, pp.19-24

Belge Tipi: Makale

Yayın Tarihi: 12/2006

Belge Dili: Türkçe

Document ID (Org No.): 2000813314

Sıklık: İki Aylık

eISSN: 1303-6092

pISSN: 1300-0152

Fagonia cretica L

cytotoxic activity

potato disc assay

mutagenic activity

Sayı

Yazarlar:

Ahsan HUSSAIN | Muhammad ZIA | Bushra MIRZA

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2007 Vol.31 Issue 1, pp.19-24

Belge Tipi:

Makale

Yayın Tarihi:

12/2006

Belge Dili:

Türkçe

Document ID (Org No.):

2000813314

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152