Antihypertensive Treatment Approaches and Oxidant-Antioxidant System Relationship in Hypertensive Type 2 Diabetic Patients

Alparslan Ersoy; Müge Erek Ersözen; Canan Ersoy; Emre Sarandöl

Makale detayları

Antihypertensive Treatment Approaches and Oxidant-Antioxidant System Relationship in Hypertensive Type 2 Diabetic Patients

Yazarlar:

Alparslan Ersoy | Müge Erek Ersözen | Canan Ersoy | Emre Sarandöl

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Endokrinoloji | İç Hastalıkları

Dergi:

Uludağ Üniversitesi Tıp Fakültesi Dergisi Vol.50 Issue 3, pp.489-496

Belge Tipi:

Makale

Yayın Tarihi:

12/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338912

pISSN:

1300-414X

Anahtar kelimeler:

Özet:

 A relationship between endothelial dysfunction and oxidative stress has been shown in the pathogenesis of diabetes andor hypertension. Antihypertensive drugs angiotensin-converting enzyme inhibitors ACEi, angiotensin II type 1 receptor blockers ARB, and third-generation beta-blockers can improve oxidative stress. This study evaluated the effects of losartan ARB treatment alone and combined with cilazapril ACEi or carvedilol on oxidative stress and antioxidants in hypertensive type 2 diabetic patients. Thirty of 56 patients completed the study. All patients received 50 mg losartan daily for 6 weeks, then were randomised into three groups for 6 weeks. In the first group, losartan was increased to 100 mgday, and in the second and third groups, carvedilol or cilazapril was added to losartan 50 mgday treatment, respectively. Apolipoprotein B malondialdehyde basal and Δ-MDA, serum paraoxonase PON and arylesterase AE, erythrocyte superoxide dismutase SOD and glutathione peroxidase Gpx parameters were studied. The characteristics of the three groups were comparable p0.05. Blood pressure BP decreased significantly in all three groups before and after randomisation in the six-week periods. The largest BP decrease was seen in the ARBACEi group systolic BP: 16.57.4 mmHg, diastolic BP: 10.52.8 mmHg, and the smallest decrease was seen in the high-dose ARB group systolic BP: 96.1 mmHg, diastolic BP: 34.8 mmHg. Throughout the study, no significant changes were detected in basal and Δ-MDA levels and SOD, Gpx, PON and AE activities in inter- and intra-group comparisons. Our observations showed that different antihypertensive therapy approaches effectively lowered BP in hypertensive type 2 diabetics but did not affect oxidant and antioxidant systems in the short term.

 A relationship between endothelial dysfunction and oxidative stress has been shown in the pathogenesis of diabetes andor hypertension. Antihypertensive drugs angiotensin-converting enzyme inhibitors ACEi, angiotensin II type 1 receptor blockers ARB, and third-generation beta-blockers can improve oxidative stress. This study evaluated the effects of losartan ARB treatment alone and combined with cilazapril ACEi or carvedilol on oxidative stress and antioxidants in hypertensive type 2 diabetic patients. Thirty of 56 patients completed the study. All patients received 50 mg losartan daily for 6 weeks, then were randomised into three groups for 6 weeks. In the first group, losartan was increased to 100 mgday, and in the second and third groups, carvedilol or cilazapril was added to losartan 50 mgday treatment, respectively. Apolipoprotein B malondialdehyde basal and Δ-MDA, serum paraoxonase PON and arylesterase AE, erythrocyte superoxide dismutase SOD and glutathione peroxidase Gpx parameters were studied. The characteristics of the three groups were comparable p0.05. Blood pressure BP decreased significantly in all three groups before and after randomisation in the six-week periods. The largest BP decrease was seen in the ARBACEi group systolic BP: 16.57.4 mmHg, diastolic BP: 10.52.8 mmHg, and the smallest decrease was seen in the high-dose ARB group systolic BP: 96.1 mmHg, diastolic BP: 34.8 mmHg. Throughout the study, no significant changes were detected in basal and Δ-MDA levels and SOD, Gpx, PON and AE activities in inter- and intra-group comparisons. Our observations showed that different antihypertensive therapy approaches effectively lowered BP in hypertensive type 2 diabetics but did not affect oxidant and antioxidant systems in the short term.

 A relationship between endothelial dysfunction and oxidative stress has been shown in the pathogenesis of diabetes andor hypertension. Antihypertensive drugs angiotensin-converting enzyme inhibitors ACEi, angiotensin II type 1 receptor blockers ARB, and third-generation beta-blockers can improve oxidative stress. This study evaluated the effects of losartan ARB treatment alone and combined with cilazapril ACEi or carvedilol on oxidative stress and antioxidants in hypertensive type 2 diabetic patients. Thirty of 56 patients completed the study. All patients received 50 mg losartan daily for 6 weeks, then were randomised into three groups for 6 weeks. In the first group, losartan was increased to 100 mgday, and in the second and third groups, carvedilol or cilazapril was added to losartan 50 mgday treatment, respectively. Apolipoprotein B malondialdehyde basal and Δ-MDA, serum paraoxonase PON and arylesterase AE, erythrocyte superoxide dismutase SOD and glutathione peroxidase Gpx parameters were studied. The characteristics of the three groups were comparable p0.05. Blood pressure BP decreased significantly in all three groups before and after randomisation in the six-week periods. The largest BP decrease was seen in the ARBACEi group systolic BP: 16.57.4 mmHg, diastolic BP: 10.52.8 mmHg, and the smallest decrease was seen in the high-dose ARB group systolic BP: 96.1 mmHg, diastolic BP: 34.8 mmHg. Throughout the study, no significant changes were detected in basal and Δ-MDA levels and SOD, Gpx, PON and AE activities in inter- and intra-group comparisons. Our observations showed that different antihypertensive therapy approaches effectively lowered BP in hypertensive type 2 diabetics but did not affect oxidant and antioxidant systems in the short term.

 Diyabet veveya hipertansiyon patogenezinde endotel disfonksiyonu ile oksidatif stres arasında ilişki olduğu bildirilmiştir. Antihipertansif ilaçlar anjiyotensin dönüştürücü enzim inhibitörleri ACEi, anjiyotensin II tip 1 reseptör blokerleri ARB ve üçüncü nesil beta blokerler oksidatif stresi iyileştirebilirler. Bu çalışmada losartan ARB tedavisinin tek başına ve silazapril ACEi veya karvedilol ile birlikte kullanımının, hipertansif tip 2 diyabetik hastalarda oksidatif stres ve antioksidanlar üzerindeki etkilerini değerlendirildi. Elli altı hastadan 30u çalışmayı tamamladı. Tüm hastalar 6 hafta boyunca günlük 50 mg losartan aldı, sonra altı hafta için 3 gruba randomize edildiler. İlk grupta losartan 100 mggüne çıkıldı, ikinci ve üçüncü gruplarda losartan 50 mggün tedavisine sırasıyla karvedilol veya silazapril eklendi. Apo B-içeren lipoproteinlerin malondialdehit bazal ve Δ-MDA, paraoksonaz PON, arilesteraz AE, eritrosit süperoksit dismutaz SOD ve glutatyon peroksidaz Gpx parametreleri çalışıldı. Üç grubun karakteristikleri karşılaştırılabilirdi p0.05. Her üç grupta da randomizasyon öncesi ve sonrası altışar haftalık dönemlerde kan basınçları KB anlamlı şekilde azaldı p0.05. En fazla KB düşüşü ARBACEi grubunda sistolik KB: 16.57.4 mmHg, diyastolik KB: 10.52.8 mmHg ve en küçük düşüş yüksek doz ARB grubunda sistolik KB: 96.1 mmHg, diyastolik KB: 34.8 mmHg görüldü. Çalışma boyunca gruplar arası ve grup içi karşılaştırmalarda bazal ve Δ-MDA, SOD, Gpx, PON ve AE aktivitelerinde anlamlı bir değişiklik saptanmadı. Gözlemlerimiz hipertansif tip 2 diyabetiklerde farklı antihipertansif terapi yaklaşımlarının KBnı düşürmede etkili olduklarını fakat kısa dönemde oksidan ve antioksidan sistemleri etkilemediğini göstermiştir.

Makale detayları

Antihypertensive Treatment Approaches and Oxidant-Antioxidant System Relationship in Hypertensive Type 2 Diabetic Patients

Yazarlar:

Alparslan Ersoy | Müge Erek Ersözen | Canan Ersoy | Emre Sarandöl

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Endokrinoloji | İç Hastalıkları

Dergi:

Uludağ Üniversitesi Tıp Fakültesi Dergisi Vol.50 Issue 3, pp.489-496

Belge Tipi:

Makale

Yayın Tarihi:

12/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338912

pISSN:

1300-414X

Type 2 diabetes mellitus

Hypertension

Antihypertensive agents

Oxidative stress

Antioxidants

Losartan

Cilazapril

CarvedilolTip 2 diabetes mellitus

Hipertansiyon

Antihipertansif ilaçlar

Oksidatif stres

Antioksidanlar

Losartan

Silazapril

Karvedilol

Sayı

Makale detayları

Yazarlar: Alparslan Ersoy | Müge Erek Ersözen | Canan Ersoy | Emre Sarandöl

Yayıncı: Bursa Uludağ University

Ana Başlıklar: Endokrinoloji | İç Hastalıkları

Dergi: Uludağ Üniversitesi Tıp Fakültesi Dergisi Vol.50 Issue 3, pp.489-496

Belge Tipi: Makale

Yayın Tarihi: 12/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001338912

pISSN: 1300-414X

Sayı

Yazarlar:

Alparslan Ersoy | Müge Erek Ersözen | Canan Ersoy | Emre Sarandöl

Yayıncı:

Bursa Uludağ University

Ana Başlıklar:

Endokrinoloji | İç Hastalıkları

Dergi:

Uludağ Üniversitesi Tıp Fakültesi Dergisi Vol.50 Issue 3, pp.489-496

Belge Tipi:

Makale

Yayın Tarihi:

12/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338912

pISSN:

1300-414X