The effects of pathophysiological changes in Type-2 diabetic patients on thyroid dysfunction and nodular goiter development in Turkey

Zeynep Ergenç; Özlem Karaca Ocak; Hasan Ergenç

Makale detayları

The effects of pathophysiological changes in Type-2 diabetic patients on thyroid dysfunction and nodular goiter development in Turkey

Yazarlar:

Zeynep Ergenç | Özlem Karaca Ocak | Hasan Ergenç

Yayıncı:

Duzce University

Ana Başlıklar:

Health Care Administration

Dergi:

Konuralp Medical Journal Vol.15 Issue 1, pp.86-90

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285280

pISSN:

1309-3878

Anahtar kelimeler:

Özet:

 Objective: The prevalence of thyroid dysfunction is higher in patients with diabetes, and its diagnosis could cause better diabetes management. The purpose of the present study is to examine the impact of pathophysiological changes in patients with Type-2 diabetes on the frequency of thyroid dysfunction, thyroid autoimmunity, thyroid nodule, and thyroid cancer in Turkey. Methods: The study was conducted on a total of 3.276 patients with Type-2 diabetes who underwent thyroid tests and thyroid ultrasonography US. The demographic characteristics, biochemical and hormonal values, thyroid US reports, and histopathology reports were collected from the patients electronic records. Results: Thyroid autoimmunity positive TPOab 15.9 n  524 andor positive TGab 9.9 n  327, the rate of positivity of both antibodies TPOab  TGab in the same patient, and total thyroid autoimmunity was found to be 32.57 n1067 in Type-2 diabetic patients. Thyroid dysfunction was detected in 18.3 n  602 of these patients. The distribution of thyroid dysfunction was 9.09 n  298 subclinical hypothyroidism, 4.1 n  135 clinical hypothyroidism, 3.1 n  102 subclinical hyperthyroidism, 2.0 n  67 clinical hyperthyroidism. Also, 67.9 n  2225 thyroid nodules, and 5 n  164 thyroid cancer were detected. Conclusion: Thyroid dysfunction was found to have increased in patients with Type-2 diabetes at significant levels.

 Objective: The prevalence of thyroid dysfunction is higher in patients with diabetes, and its diagnosis could cause better diabetes management. The purpose of the present study is to examine the impact of pathophysiological changes in patients with Type-2 diabetes on the frequency of thyroid dysfunction, thyroid autoimmunity, thyroid nodule, and thyroid cancer in Turkey. Methods: The study was conducted on a total of 3.276 patients with Type-2 diabetes who underwent thyroid tests and thyroid ultrasonography US. The demographic characteristics, biochemical and hormonal values, thyroid US reports, and histopathology reports were collected from the patients electronic records. Results: Thyroid autoimmunity positive TPOab 15.9 n  524 andor positive TGab 9.9 n  327, the rate of positivity of both antibodies TPOab  TGab in the same patient, and total thyroid autoimmunity was found to be 32.57 n1067 in Type-2 diabetic patients. Thyroid dysfunction was detected in 18.3 n  602 of these patients. The distribution of thyroid dysfunction was 9.09 n  298 subclinical hypothyroidism, 4.1 n  135 clinical hypothyroidism, 3.1 n  102 subclinical hyperthyroidism, 2.0 n  67 clinical hyperthyroidism. Also, 67.9 n  2225 thyroid nodules, and 5 n  164 thyroid cancer were detected. Conclusion: Thyroid dysfunction was found to have increased in patients with Type-2 diabetes at significant levels.

 Objective: The prevalence of thyroid dysfunction is higher in patients with diabetes, and its diagnosis could cause better diabetes management. The purpose of the present study is to examine the impact of pathophysiological changes in patients with Type-2 diabetes on the frequency of thyroid dysfunction, thyroid autoimmunity, thyroid nodule, and thyroid cancer in Turkey. Methods: The study was conducted on a total of 3.276 patients with Type-2 diabetes who underwent thyroid tests and thyroid ultrasonography US. The demographic characteristics, biochemical and hormonal values, thyroid US reports, and histopathology reports were collected from the patients electronic records. Results: Thyroid autoimmunity positive TPOab 15.9 n  524 andor positive TGab 9.9 n  327, the rate of positivity of both antibodies TPOab  TGab in the same patient, and total thyroid autoimmunity was found to be 32.57 n1067 in Type-2 diabetic patients. Thyroid dysfunction was detected in 18.3 n  602 of these patients. The distribution of thyroid dysfunction was 9.09 n  298 subclinical hypothyroidism, 4.1 n  135 clinical hypothyroidism, 3.1 n  102 subclinical hyperthyroidism, 2.0 n  67 clinical hyperthyroidism. Also, 67.9 n  2225 thyroid nodules, and 5 n  164 thyroid cancer were detected. Conclusion: Thyroid dysfunction was found to have increased in patients with Type-2 diabetes at significant levels.

 Amaç: Bu çalışmanın amacı, Türkiyede Tip 2 diyabetli hastalardaki patofizyolojik değişikliklerin tiroid disfonksiyonu, tiroid otoimmünitesi, tiroid nodülü ve tiroid kanseri sıklığına etkisini incelemektir. Gereç ve Yöntem: Çalışma, tiroid testleri ve tiroid ultrasonografisi US yapılan toplam 3.276 Tip-2 diyabetli hasta üzerinde yapıldı. Demografik özellikler, biyokimyasal ve hormonal değerler, tiroid US raporları ve histopatoloji raporları hastaların elektronik kayıtlarından toplandı. Bulgular:Tiroid otoimmünite pozitif TPOab 15.9 n  524 veveya pozitif TGab 9.9 n327, aynı hastada her iki antikorun TPOab  TGab pozitiflik oranı ve total tiroid otoimmünitesi Tip-2 diyabetli hastalarda 32,57 n1067 olabilir. Bu hastaların 18,3ünde n602 tiroid disfonksiyonu saptandı. Tiroid disfonksiyonu dağılımı 9.09 n298 subklinik hipotiroidi, 4.1 n135 klinik hipotiroidi, 3.1 n102 subklinik hipertiroidi, 2.0 n67 klinik hipertiroidi idi. Ayrıca 67.9 n2225 tiroid nodülü ve 5 n164 tiroid kanseri tespit edildi. Sonuç: Tip-2 diyabetli hastalarda tiroid disfonksiyonunun anlamlı düzeyde arttığı bulundu.

Makale detayları

The effects of pathophysiological changes in Type-2 diabetic patients on thyroid dysfunction and nodular goiter development in Turkey

Yazarlar:

Zeynep Ergenç | Özlem Karaca Ocak | Hasan Ergenç

Yayıncı:

Duzce University

Ana Başlıklar:

Health Care Administration

Dergi:

Konuralp Medical Journal Vol.15 Issue 1, pp.86-90

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285280

pISSN:

1309-3878

Type-2 diabetes

thyroid dysfunction

nodular goiter

thyroid autoimmunity

Tip-2 diyabet

Tiroid disfonksiyonu

Nodüler guatr

Tiroid otoimmünitesi

Sayı

Makale detayları

Yazarlar: Zeynep Ergenç | Özlem Karaca Ocak | Hasan Ergenç

Yayıncı: Duzce University

Ana Başlıklar: Health Care Administration

Dergi: Konuralp Medical Journal Vol.15 Issue 1, pp.86-90

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001285280

pISSN: 1309-3878

Sayı

Yazarlar:

Zeynep Ergenç | Özlem Karaca Ocak | Hasan Ergenç

Yayıncı:

Duzce University

Ana Başlıklar:

Health Care Administration

Dergi:

Konuralp Medical Journal Vol.15 Issue 1, pp.86-90

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285280

pISSN:

1309-3878