Quercetin-maleic acid co-crystal engineering using solvent  evaporation to ıncrease quercetin solubility

Yudi Wicaksono; Elvina Herawati

Makale detayları

Quercetin-maleic acid co-crystal engineering using solvent evaporation to ıncrease quercetin solubility

Yazarlar:

Yudi Wicaksono | Elvina Herawati

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacy Management

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 6, pp.1982-1988

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001334771

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 This study aims to produce quercetin-maleic acid cocrystals with an increase in solubility properties. The preparation of quercetin-maleic acid cocrystal CQAM was carried out by solvent evaporation method using ethanol as a solvent. The quercetin-maleic acid cocrystal preparation was formed with two different stoichiometric ratios, namely quercetin-maleic acid 1:1 and 1:3. Solubility tests on quercetin-maleic acid cocrystals were carried out in 50 mL citrate buffer pH 5 at 370.5C. The characterization tests used were DSC, PXRD, FTIR, and SEM, while for the evaluation, solubility tests were carried out. The results of DSC, PXRD, FTIR and SEM showed the formation of a new solid with the type of crystalline solid, so it was concluded as a cocrystalline solid. The results of the solubility test showed that the solubility value of quercetin-maleic acid cocrystal 1:1 and 1:3 was greater than that of pure quercetin. Solubility result of pure quercetin, CQAM 1:1 and CQAM 1:3 were 0.545  0.0351 mgL; 2.237  0.0258 mgL; and 6.352  0.0258 mgL, respectively. Quercetinmaleic acid cocrystals 1:1 and 1:3 experienced an increase in solubility of 4.11 and 11.65 times, respectively, from pure quercetin.

 This study aims to produce quercetin-maleic acid cocrystals with an increase in solubility properties. The preparation of quercetin-maleic acid cocrystal CQAM was carried out by solvent evaporation method using ethanol as a solvent. The quercetin-maleic acid cocrystal preparation was formed with two different stoichiometric ratios, namely quercetin-maleic acid 1:1 and 1:3. Solubility tests on quercetin-maleic acid cocrystals were carried out in 50 mL citrate buffer pH 5 at 370.5C. The characterization tests used were DSC, PXRD, FTIR, and SEM, while for the evaluation, solubility tests were carried out. The results of DSC, PXRD, FTIR and SEM showed the formation of a new solid with the type of crystalline solid, so it was concluded as a cocrystalline solid. The results of the solubility test showed that the solubility value of quercetin-maleic acid cocrystal 1:1 and 1:3 was greater than that of pure quercetin. Solubility result of pure quercetin, CQAM 1:1 and CQAM 1:3 were 0.545  0.0351 mgL; 2.237  0.0258 mgL; and 6.352  0.0258 mgL, respectively. Quercetinmaleic acid cocrystals 1:1 and 1:3 experienced an increase in solubility of 4.11 and 11.65 times, respectively, from pure quercetin.

 This study aims to produce quercetin-maleic acid cocrystals with an increase in solubility properties. The preparation of quercetin-maleic acid cocrystal CQAM was carried out by solvent evaporation method using ethanol as a solvent. The quercetin-maleic acid cocrystal preparation was formed with two different stoichiometric ratios, namely quercetin-maleic acid 1:1 and 1:3. Solubility tests on quercetin-maleic acid cocrystals were carried out in 50 mL citrate buffer pH 5 at 370.5C. The characterization tests used were DSC, PXRD, FTIR, and SEM, while for the evaluation, solubility tests were carried out. The results of DSC, PXRD, FTIR and SEM showed the formation of a new solid with the type of crystalline solid, so it was concluded as a cocrystalline solid. The results of the solubility test showed that the solubility value of quercetin-maleic acid cocrystal 1:1 and 1:3 was greater than that of pure quercetin. Solubility result of pure quercetin, CQAM 1:1 and CQAM 1:3 were 0.545  0.0351 mgL; 2.237  0.0258 mgL; and 6.352  0.0258 mgL, respectively. Quercetinmaleic acid cocrystals 1:1 and 1:3 experienced an increase in solubility of 4.11 and 11.65 times, respectively, from pure quercetin.

 This study aims to produce quercetin-maleic acid cocrystals with an increase in solubility properties. The preparation of quercetin-maleic acid cocrystal CQAM was carried out by solvent evaporation method using ethanol as a solvent. The quercetin-maleic acid cocrystal preparation was formed with two different stoichiometric ratios, namely quercetin-maleic acid 1:1 and 1:3. Solubility tests on quercetin-maleic acid cocrystals were carried out in 50 mL citrate buffer pH 5 at 370.5C. The characterization tests used were DSC, PXRD, FTIR, and SEM, while for the evaluation, solubility tests were carried out. The results of DSC, PXRD, FTIR and SEM showed the formation of a new solid with the type of crystalline solid, so it was concluded as a cocrystalline solid. The results of the solubility test showed that the solubility value of quercetin-maleic acid cocrystal 1:1 and 1:3 was greater than that of pure quercetin. Solubility result of pure quercetin, CQAM 1:1 and CQAM 1:3 were 0.545  0.0351 mgL; 2.237  0.0258 mgL; and 6.352  0.0258 mgL, respectively. Quercetinmaleic acid cocrystals 1:1 and 1:3 experienced an increase in solubility of 4.11 and 11.65 times, respectively, from pure quercetin.

Makale detayları

Quercetin-maleic acid co-crystal engineering using solvent evaporation to ıncrease quercetin solubility

Yazarlar:

Yudi Wicaksono | Elvina Herawati

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacy Management

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 6, pp.1982-1988

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001334771

pISSN:

2630-6344

Cocrystal

Quercetin

Maleic Acid

Solvent Evaporation

Solubility

Sayı

Makale detayları

Quercetin-maleic acid co-crystal engineering using solvent evaporation to ıncrease quercetin solubility

Yazarlar: Yudi Wicaksono | Elvina Herawati

Yayıncı: Marmara University

Ana Başlıklar: Pharmacy Management

Dergi: Journal of Research in Pharmacy Vol.28 Issue 6, pp.1982-1988

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001334771

pISSN: 2630-6344

Cocrystal

Quercetin

Maleic Acid

Solvent Evaporation

Solubility

Sayı

Yazarlar:

Yudi Wicaksono | Elvina Herawati

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacy Management

Dergi:

Journal of Research in Pharmacy Vol.28 Issue 6, pp.1982-1988

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001334771

pISSN:

2630-6344