Investigation of The Effect of 25(OH)D3 Levels on the Disease Severity and the Course of the Treatment in Active Pulmonary Tuberculosis Patients

Esma Seda Akalın Karaca; Gonenc Ortaköylü

Makale detayları

Investigation of The Effect of 25(OH)D3 Levels on the Disease Severity and the Course of the Treatment in Active Pulmonary Tuberculosis Patients

Yazarlar:

Esma Seda Akalın Karaca | Gonenc Ortaköylü

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Public Health (Other) | Health Care Administration

Dergi:

Meandros Medical And Dental Journal Vol.26 Issue 2, pp.185-192

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348321

pISSN:

2149-9063

Anahtar kelimeler:

Özet:

 Background and Aim: Emerging evidence suggests a link between vitamin D deficiency and increased susceptibility to TB. Vitamin D regulates calcium, phosphorus, and bone metabolism and plays a pivotal role in immune responses. This study investigates the relationship between 25OHD3 levels and the clinical course, radiological findings, and treatment outcomes in TB patients. Materials and Methods: This prospective study was conducted over ten months at a tertiary care hospital, involving 70 newly diagnosed TB patients aged 18-69 years and 20 healthy controls. TB diagnosis was confirmed through clinical, radiological, and microbiological findings, including acid-resistant bacteria ARB smear and M. tuberculosis culture positivity. All participants underwent physical examinations, routine blood tests, and serum 25OHD3 level measurements. Serum 25OHD3 levels were categorized as deficient 10 ngmL, insufficient 10-24 ngmL, or adequate 25-80 ngmL. Results: The mean age of TB patients was 39.7  16.8 years, with a control group mean age of 42.3  14.5 years. Serum 25OHD3 levels were significantly lower in TB patients 22.01  9.24 ngmL compared to controls 37.8  18 ngmL, p  0.001. Among TB patients, 43 61.5 had deficient or insufficient vitamin D levels, with six exhibiting severe deficiency 10 ngmL. Higher 25OHD3 levels correlated positively with hemoglobin Hb, hematocrit Hct, total protein, albumin, and calcium levels, and negatively with white blood cell WBC count. No significant relationship was found between 25OHD3 levels and sputum smear negativity at two months. However, patients with higher baseline 25OHD3 levels showed better radiological improvement after one month of treatment p  0.05, r  -0.223. Conclusion: Low serum 25OHD3 levels are associated with greater TB severity and slower radiological improvement. These findings underscore the potential role of vitamin D in modulating TB progression and recovery. Further studies are needed to evaluate the therapeutic benefits of vitamin D supplementation in TB management.

 Background and Aim: Emerging evidence suggests a link between vitamin D deficiency and increased susceptibility to TB. Vitamin D regulates calcium, phosphorus, and bone metabolism and plays a pivotal role in immune responses. This study investigates the relationship between 25OHD3 levels and the clinical course, radiological findings, and treatment outcomes in TB patients. Materials and Methods: This prospective study was conducted over ten months at a tertiary care hospital, involving 70 newly diagnosed TB patients aged 18-69 years and 20 healthy controls. TB diagnosis was confirmed through clinical, radiological, and microbiological findings, including acid-resistant bacteria ARB smear and M. tuberculosis culture positivity. All participants underwent physical examinations, routine blood tests, and serum 25OHD3 level measurements. Serum 25OHD3 levels were categorized as deficient 10 ngmL, insufficient 10-24 ngmL, or adequate 25-80 ngmL. Results: The mean age of TB patients was 39.7  16.8 years, with a control group mean age of 42.3  14.5 years. Serum 25OHD3 levels were significantly lower in TB patients 22.01  9.24 ngmL compared to controls 37.8  18 ngmL, p  0.001. Among TB patients, 43 61.5 had deficient or insufficient vitamin D levels, with six exhibiting severe deficiency 10 ngmL. Higher 25OHD3 levels correlated positively with hemoglobin Hb, hematocrit Hct, total protein, albumin, and calcium levels, and negatively with white blood cell WBC count. No significant relationship was found between 25OHD3 levels and sputum smear negativity at two months. However, patients with higher baseline 25OHD3 levels showed better radiological improvement after one month of treatment p  0.05, r  -0.223. Conclusion: Low serum 25OHD3 levels are associated with greater TB severity and slower radiological improvement. These findings underscore the potential role of vitamin D in modulating TB progression and recovery. Further studies are needed to evaluate the therapeutic benefits of vitamin D supplementation in TB management.

 Background and Aim: Emerging evidence suggests a link between vitamin D deficiency and increased susceptibility to TB. Vitamin D regulates calcium, phosphorus, and bone metabolism and plays a pivotal role in immune responses. This study investigates the relationship between 25OHD3 levels and the clinical course, radiological findings, and treatment outcomes in TB patients. Materials and Methods: This prospective study was conducted over ten months at a tertiary care hospital, involving 70 newly diagnosed TB patients aged 18-69 years and 20 healthy controls. TB diagnosis was confirmed through clinical, radiological, and microbiological findings, including acid-resistant bacteria ARB smear and M. tuberculosis culture positivity. All participants underwent physical examinations, routine blood tests, and serum 25OHD3 level measurements. Serum 25OHD3 levels were categorized as deficient 10 ngmL, insufficient 10-24 ngmL, or adequate 25-80 ngmL. Results: The mean age of TB patients was 39.7  16.8 years, with a control group mean age of 42.3  14.5 years. Serum 25OHD3 levels were significantly lower in TB patients 22.01  9.24 ngmL compared to controls 37.8  18 ngmL, p  0.001. Among TB patients, 43 61.5 had deficient or insufficient vitamin D levels, with six exhibiting severe deficiency 10 ngmL. Higher 25OHD3 levels correlated positively with hemoglobin Hb, hematocrit Hct, total protein, albumin, and calcium levels, and negatively with white blood cell WBC count. No significant relationship was found between 25OHD3 levels and sputum smear negativity at two months. However, patients with higher baseline 25OHD3 levels showed better radiological improvement after one month of treatment p  0.05, r  -0.223. Conclusion: Low serum 25OHD3 levels are associated with greater TB severity and slower radiological improvement. These findings underscore the potential role of vitamin D in modulating TB progression and recovery. Further studies are needed to evaluate the therapeutic benefits of vitamin D supplementation in TB management.

 Amaç: Tüberküloz TB, önemli bir küresel sağlık sorunu olmaya devam etmektedir. D vitamini eksikliğinin, artmış hastalık şiddeti ve progresyonuyla bağlantılı olduğuna dair yeni kanıtlar ortaya çıkmaya devam etmektedir. D vitamini, özellikle makrofaj aktivasyonu ve antimikrobiyal savunmada bağışıklık tepkilerinde önemli bir rol oynarken kalsiyum, fosfor ve kemik metabolizmasını düzenler. Bu çalışma, TB hastalarında serum 25OHD3 düzeyleri ile klinik, radyolojik ve tedavi sonuçları arasındaki ilişkiyi değerlendirmeyi amaçlamaktadır. Yöntem ve Gereçler: Yeni tanı almış 70 TB hastası 18-69 yaş ve 20 sağlıklı kontrol içeren prospektif bir çalışma on ay boyunca yürütülmüştür. TB tanısı, ARB yayması ve M. tuberculosis kültür pozitifliği dahil olmak üzere klinik, radyolojik ve mikrobiyolojik bulgularla doğrulanmıştır. Katılımcılara fiziksel muayeneler, rutin kan testleri ve serum 25OHD3 düzeyi ölçümleri yapılmıştır. D vitamini düzeyleri eksik 10 ngmL, yetersiz 10-24 ngmL veya yeterli 25-80 ngmL olarak kategorize edilmiştir. Bulgular: TB hastalarında ortalama serum 25OHD3 düzeyi 22,019,24 ngmL olarak, kontrollerden 37,818 ngmL, p0,001 önemli ölçüde düşü saptanmıştır. TB hastalarının 61,5inde eksik veya yetersiz 25OHD3 düzeyleri gözlenirken, 6 kişide ciddi eksiklik 10 ngmL saptanmıştır. Yüksek 25OHD3 düzeyleri hemoglobin, hematokrit, albümin ve kalsiyum düzeyleri ile pozitif, WBC sayısı ile negatif korelasyon göstermiştir. Daha yüksek 25OHD3 düzeylerine sahip hastalarda, bir aylık tedaviden sonra daha iyi radyolojik iyileşme bulguları saptanmıştır p0,05, r -0,223. Sonuç: Çalışma, düşük 25OHD3 düzeylerinin TB şiddetinin artması ve iyileşmenin gecikmesi ile ilişkili olduğu sonucuna vararak, TB yönetiminde D vitamini takviyesi konusunda daha fazla araştırma yapılması gerektiğini vurgulamaktadır.

Makale detayları

Investigation of The Effect of 25(OH)D3 Levels on the Disease Severity and the Course of the Treatment in Active Pulmonary Tuberculosis Patients

Yazarlar:

Esma Seda Akalın Karaca | Gonenc Ortaköylü

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Public Health (Other) | Health Care Administration

Dergi:

Meandros Medical And Dental Journal Vol.26 Issue 2, pp.185-192

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348321

pISSN:

2149-9063

Vitamin D

tuberculosis

25OHVitaminDtüberküloz

D vitamini

25(OH)D3

progresyon

bulgular

Sayı

Makale detayları

Yazarlar: Esma Seda Akalın Karaca | Gonenc Ortaköylü

Yayıncı: Aydin Adnan Menderes University

Ana Başlıklar: Public Health (Other) | Health Care Administration

Dergi: Meandros Medical And Dental Journal Vol.26 Issue 2, pp.185-192

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001348321

pISSN: 2149-9063

Sayı

Yazarlar:

Esma Seda Akalın Karaca | Gonenc Ortaköylü

Yayıncı:

Aydin Adnan Menderes University

Ana Başlıklar:

Public Health (Other) | Health Care Administration

Dergi:

Meandros Medical And Dental Journal Vol.26 Issue 2, pp.185-192

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348321

pISSN:

2149-9063