Pluripotent stem cells and their use in hearing loss

Ahmet Hamdi KEPEKÇİ; Okan Özgür ÖZTURAN; Mustafa Yavuz KÖKER

Makale detayları

Pluripotent stem cells and their use in hearing loss

Yazarlar:

Ahmet Hamdi KEPEKÇİ | Okan Özgür ÖZTURAN | Mustafa Yavuz KÖKER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2016 Vol.40 Issue 5, pp.1033-1039

Belge Tipi:

Makale

Yayın Tarihi:

9/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000811573

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152

Özet:

 

Throughout its half a century of development, stem cell research has included two main fields: embryonic stem (ES) cell research and the reprogramming of body somatic cells. In the present review we focused on stem cell reprogramming and its relation with otolaryngology. The human body somatic cells are transformed into pluripotent cells by three basic methods: the somatic nuclear transfer method, the somatic cell fusion method (getting cellular pluripotent capacity in cellular reprogramming), and by transcription factors influencing the body somatic cells to generate reprogrammed induced pluripotent stem (iPS) cells.  ES cells and iPS cells have pluripotency and differentiate into cells originating from the three germ layers; they are preferred for cellular treatment, drug development, and disease modeling research. Because of ethical restrictions in obtaining ES cells, iPS cells are an alternative pluripotent cell source and patient-specific autologous pluripotent cells are obtained by this method. Cellular treatment and regenerative medicine with pluripotent cells are currently developing and we aimed to raise awareness about this topic in our paper on using iPS cell technology in the biological treatment of hearing loss, which is an important area of research in otolaryngology.

Makale detayları

Pluripotent stem cells and their use in hearing loss

Yazarlar: Ahmet Hamdi KEPEKÇİ | Okan Özgür ÖZTURAN | Mustafa Yavuz KÖKER

Yayıncı: TUBITAK

Dergi: Turkish Journal of Biology 2016 Vol.40 Issue 5, pp.1033-1039

Belge Tipi: Makale

Yayın Tarihi: 9/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000811573

Sıklık: İki Aylık

eISSN: 1303-6092

pISSN: 1300-0152

Sayı

Yazarlar:

Ahmet Hamdi KEPEKÇİ | Okan Özgür ÖZTURAN | Mustafa Yavuz KÖKER

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Biology 2016 Vol.40 Issue 5, pp.1033-1039

Belge Tipi:

Makale

Yayın Tarihi:

9/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000811573

Sıklık:

İki Aylık

eISSN:

1303-6092

pISSN:

1300-0152