Evaluation of the relationship between graft failure after tympanoplasty and smoking status and preoperative inflammatory markers

Volkan Gungor; Kaan Turan Tercan

Makale detayları

Evaluation of the relationship between graft failure after tympanoplasty and smoking status and preoperative inflammatory markers

Yazarlar:

Volkan Gungor | Kaan Turan Tercan

Yayıncı:

Ordu University

Ana Başlıklar:

Kulak Burun Boğaz

Dergi:

ODÜ Tıp Dergisi Vol.12 Issue 2, pp.34-42

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357585

pISSN:

2148-6816

Anahtar kelimeler:

Özet:

 This study aimed to investigate the relationship between graft success in patients undergoing tympanoplasty with various techniques and smoking status, as well as preoperative complete blood count CBC-based inflammatory markers CRP, WBC, NLR, PLR, RDW. This retrospective study included 40 patients who underwent tympanoplasty in our clinic between 2023 and 2025. Patients were divided into two groups based on graft success as not-failed and failed. Smoking status, surgical technique, and inflammatory laboratory parameters were recorded. Fishers Exact Test, Chi-square Test, and MannWhitney U Test were used for statistical analyses p  0.05 was considered significant. A statistically significant association was found between smoking status and graft failure p  0.001. CRP levels were not statistically significant p  0.055, but showed borderline results. No significant relationship was observed between graft outcomes and other inflammatory markers such as WBC, NLR, PLR, and RDW. Surgical techniques also did not significantly affect graft success p  0.144. These findings shows the importance of advising patients to stop smoking before surgery to improve the graft success rates.

 This study aimed to investigate the relationship between graft success in patients undergoing tympanoplasty with various techniques and smoking status, as well as preoperative complete blood count CBC-based inflammatory markers CRP, WBC, NLR, PLR, RDW. This retrospective study included 40 patients who underwent tympanoplasty in our clinic between 2023 and 2025. Patients were divided into two groups based on graft success as not-failed and failed. Smoking status, surgical technique, and inflammatory laboratory parameters were recorded. Fishers Exact Test, Chi-square Test, and MannWhitney U Test were used for statistical analyses p  0.05 was considered significant. A statistically significant association was found between smoking status and graft failure p  0.001. CRP levels were not statistically significant p  0.055, but showed borderline results. No significant relationship was observed between graft outcomes and other inflammatory markers such as WBC, NLR, PLR, and RDW. Surgical techniques also did not significantly affect graft success p  0.144. These findings shows the importance of advising patients to stop smoking before surgery to improve the graft success rates.

 This study aimed to investigate the relationship between graft success in patients undergoing tympanoplasty with various techniques and smoking status, as well as preoperative complete blood count CBC-based inflammatory markers CRP, WBC, NLR, PLR, RDW. This retrospective study included 40 patients who underwent tympanoplasty in our clinic between 2023 and 2025. Patients were divided into two groups based on graft success as not-failed and failed. Smoking status, surgical technique, and inflammatory laboratory parameters were recorded. Fishers Exact Test, Chi-square Test, and MannWhitney U Test were used for statistical analyses p  0.05 was considered significant. A statistically significant association was found between smoking status and graft failure p  0.001. CRP levels were not statistically significant p  0.055, but showed borderline results. No significant relationship was observed between graft outcomes and other inflammatory markers such as WBC, NLR, PLR, and RDW. Surgical techniques also did not significantly affect graft success p  0.144. These findings shows the importance of advising patients to stop smoking before surgery to improve the graft success rates.

 Bu çalışma, farklı tekniklerle timpanoplasti uygulanan hastalarda greft başarısı ile sigara kullanımı durumu ve preoperatif tam kan sayımına CBC dayalı inflamatuar belirteçler CRP, WBC, NLR, PLR, RDW arasındaki ilişkiyi araştırmayı amaçlamaktadır. Bu retrospektif çalışmaya, 2023 ile 2025 yılları arasında kliniğimizde timpanoplasti ameliyatı geçiren 40 hasta dâhil edilmiştir. Hastalar, greft başarısına göre başarısız ve başarılı olmak üzere iki gruba ayrılmıştır. Sigara içme durumu, cerrahi teknik ve inflamatuar laboratuvar parametreleri kaydedilmiştir. İstatistiksel analizlerde Fishers Exact Test, Ki-kare Testi ve MannWhitney U Testi kullanılmıştır p  0.05 anlamlı kabul edilmiştir. Sigara içme durumu ile greft başarısızlığı arasında istatistiksel olarak anlamlı bir ilişki bulunmuştur p  0.001. CRP düzeyleri istatistiksel olarak anlamlı olmamakla birlikte sınırda anlamlılık göstermiştir p  0.055. Greft sonuçları ile WBC, NLR, PLR ve RDW gibi diğer inflamatuar belirteçler arasında anlamlı bir ilişki gözlenmemiştir. Uygulanan cerrahi tekniklerin de greft başarısını anlamlı şekilde etkilemediği görülmüştür p  0.144. Bu bulgular, greft başarısını artırmak için hastalara ameliyat öncesi sigarayı bırakmalarının önerilmesinin önemini ortaya koymaktadır.

Makale detayları

Evaluation of the relationship between graft failure after tympanoplasty and smoking status and preoperative inflammatory markers

Yazarlar:

Volkan Gungor | Kaan Turan Tercan

Yayıncı:

Ordu University

Ana Başlıklar:

Kulak Burun Boğaz

Dergi:

ODÜ Tıp Dergisi Vol.12 Issue 2, pp.34-42

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357585

pISSN:

2148-6816

Tympanoplasty

Graft Survival

Smoking

C-Reactive Protein

Biomarkers

InflammationTimpanoplasti

Greft Sağkalımı

Sigara Kullanımı

C-Reaktif Protein

Biyobelirteçler

İnflamasyon

Sayı

Makale detayları

Yazarlar: Volkan Gungor | Kaan Turan Tercan

Yayıncı: Ordu University

Ana Başlıklar: Kulak Burun Boğaz

Dergi: ODÜ Tıp Dergisi Vol.12 Issue 2, pp.34-42

Belge Tipi: Makale

Yayın Tarihi: 8/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001357585

pISSN: 2148-6816

Sayı

Yazarlar:

Volkan Gungor | Kaan Turan Tercan

Yayıncı:

Ordu University

Ana Başlıklar:

Kulak Burun Boğaz

Dergi:

ODÜ Tıp Dergisi Vol.12 Issue 2, pp.34-42

Belge Tipi:

Makale

Yayın Tarihi:

8/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001357585

pISSN:

2148-6816