EVALUATION OF LIVER ELASTICITY USING pSWE AND 2D-SWE TECHNIQUES IN HEALTHY CHILDREN

Hüseyin Aydın; Fatma İssi

Makale detayları

EVALUATION OF LIVER ELASTICITY USING pSWE AND 2D-SWE TECHNIQUES IN HEALTHY CHILDREN

Yazarlar:

Hüseyin Aydın | Fatma İssi

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Clinical Sciences

Dergi:

Medical Journal of Süleyman Demirel University Vol.30 Issue 1, pp.69-77

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285089

pISSN:

1300-7416

Anahtar kelimeler:

Özet:

 Objective Shear wave elastography SWE is a new ultrasonography technique that can non-invasively evaluate liver stiffness. The efficacy of SWE in adults has been demonstrated by numerous studies, but there are few SWE studies of pediatric groups. Since the liver stiffness values LSV vary according to the device and the SWE method used, standard reference values have not been established as yet. The aim of this study was to establish the reference values of normal liver stiffness in healthy children according to the two SWE methods. Materials and Method Liver stiffness values were measured using the two different SWE methods of point SWE pSWE and 2-dimensional SWE 2D-SWE in 107 healthy children aged 8-18 years with no liver disease. The pSWE EPQ and 2D-SWE EQI measurements were taken in one session on the same device Philips Epiq Elite and after at least 4 hours of fasting. The effects on liver elasticity values were investigated of gender, age, body mass index BMI, some biochemical markers such as fasting blood glucose, aspartate aminotransferase AST, alanine aminotransferase ALT, albumin, platelet, INR and liver size. Results The mean LSV was 4.040.84kPa 95 confidence interval CI:3.67-4.42 on pSWE and 4.410.71kPa 95 CI:4.09-4.72 on 2D-SWE. The upper limit LSVs were found to be 4.42kPa and 4.72kPa, respectively. The LSVs measured on 2D-SWE were found to be higher than on pSWE median; min-max, 4.34kPa; 2.82-6kPa and 3.86kPa; 2.555.78, respectively, r0.59, p0.001. A low-level significant positive correlation was determined between LSV and age r0.267; p0.006. No significant association was determined between LSV and hepatic size, gender, BMI and biochemical markers. Conclusion In healthy children aged 8-18 years, the mean liver stiffness reference values obtained on the Philips Epiq Elite ultrasound device were 4.040.84kPa using the pSWE method and 4.410.71kPa using the 2D-SWE method.These reference values will help the SWE method to be used more effectively in the evaluation of liver parenchyma in chronic liver diseases.

 Objective Shear wave elastography SWE is a new ultrasonography technique that can non-invasively evaluate liver stiffness. The efficacy of SWE in adults has been demonstrated by numerous studies, but there are few SWE studies of pediatric groups. Since the liver stiffness values LSV vary according to the device and the SWE method used, standard reference values have not been established as yet. The aim of this study was to establish the reference values of normal liver stiffness in healthy children according to the two SWE methods. Materials and Method Liver stiffness values were measured using the two different SWE methods of point SWE pSWE and 2-dimensional SWE 2D-SWE in 107 healthy children aged 8-18 years with no liver disease. The pSWE EPQ and 2D-SWE EQI measurements were taken in one session on the same device Philips Epiq Elite and after at least 4 hours of fasting. The effects on liver elasticity values were investigated of gender, age, body mass index BMI, some biochemical markers such as fasting blood glucose, aspartate aminotransferase AST, alanine aminotransferase ALT, albumin, platelet, INR and liver size. Results The mean LSV was 4.040.84kPa 95 confidence interval CI:3.67-4.42 on pSWE and 4.410.71kPa 95 CI:4.09-4.72 on 2D-SWE. The upper limit LSVs were found to be 4.42kPa and 4.72kPa, respectively. The LSVs measured on 2D-SWE were found to be higher than on pSWE median; min-max, 4.34kPa; 2.82-6kPa and 3.86kPa; 2.555.78, respectively, r0.59, p0.001. A low-level significant positive correlation was determined between LSV and age r0.267; p0.006. No significant association was determined between LSV and hepatic size, gender, BMI and biochemical markers. Conclusion In healthy children aged 8-18 years, the mean liver stiffness reference values obtained on the Philips Epiq Elite ultrasound device were 4.040.84kPa using the pSWE method and 4.410.71kPa using the 2D-SWE method.These reference values will help the SWE method to be used more effectively in the evaluation of liver parenchyma in chronic liver diseases.

 Objective Shear wave elastography SWE is a new ultrasonography technique that can non-invasively evaluate liver stiffness. The efficacy of SWE in adults has been demonstrated by numerous studies, but there are few SWE studies of pediatric groups. Since the liver stiffness values LSV vary according to the device and the SWE method used, standard reference values have not been established as yet. The aim of this study was to establish the reference values of normal liver stiffness in healthy children according to the two SWE methods. Materials and Method Liver stiffness values were measured using the two different SWE methods of point SWE pSWE and 2-dimensional SWE 2D-SWE in 107 healthy children aged 8-18 years with no liver disease. The pSWE EPQ and 2D-SWE EQI measurements were taken in one session on the same device Philips Epiq Elite and after at least 4 hours of fasting. The effects on liver elasticity values were investigated of gender, age, body mass index BMI, some biochemical markers such as fasting blood glucose, aspartate aminotransferase AST, alanine aminotransferase ALT, albumin, platelet, INR and liver size. Results The mean LSV was 4.040.84kPa 95 confidence interval CI:3.67-4.42 on pSWE and 4.410.71kPa 95 CI:4.09-4.72 on 2D-SWE. The upper limit LSVs were found to be 4.42kPa and 4.72kPa, respectively. The LSVs measured on 2D-SWE were found to be higher than on pSWE median; min-max, 4.34kPa; 2.82-6kPa and 3.86kPa; 2.555.78, respectively, r0.59, p0.001. A low-level significant positive correlation was determined between LSV and age r0.267; p0.006. No significant association was determined between LSV and hepatic size, gender, BMI and biochemical markers. Conclusion In healthy children aged 8-18 years, the mean liver stiffness reference values obtained on the Philips Epiq Elite ultrasound device were 4.040.84kPa using the pSWE method and 4.410.71kPa using the 2D-SWE method.These reference values will help the SWE method to be used more effectively in the evaluation of liver parenchyma in chronic liver diseases.

 Amaç Share wave elastografi SWE, karaciğer sertliğini non-invaziv olarak değerlendirebilen yeni bir ultrasonografi tekniğidir. Yetişkinlerde SWEnin etkinliği çok sayıda çalışmayla gösterilmiştir, ancak pediatrik gruplarda çok az SWE çalışması vardır. Karaciğer sertliği değerleri KSD, cihaza ve kullanılan SWE yöntemine göre değişiklik gösterdiğinden, standart referans değerleri henüz oluşturulmamıştır. Bu çalışmanın amacı, iki farklı SWE yöntemine göre, sağlıklı çocuklarda normal karaciğerin referans sertlik değerlerini belirlemekti. Gereç ve Yöntem Karaciğer sertliği değerleri, 8-18 yaş arası 107 sağlıklı çocukta, iki farklı SWE yöntemi olan point SWE pSWE ve 2-dimentional SWE 2D-SWE ile ölçüldü. pSWE EPQ ve 2D-SWE EQI ölçümleri aynı cihaz Philips Epiq Elite ile, tek seansta ve en az 4 saat aç kaldıktan sonra alındı. Cinsiyet, yaş, vücut kitle indeksi VKİ, bazı biyokimyasal belirteçler açlık kan şekeri, aspartat aminotransferaz AST, alanin aminotransferaz ALT, albümin, trombosit, INR gibi ve karaciğer boyutunun, KSDye etkisi araştırıldı. Bulgular Ortalama KSD, pSWE ile 4,040,84kPa 95 güven aralığı CI:3,67-4,42 ve 2D-SWE ile 4,410,71kPa 95 CI:4,09-4,72 bulundu. Üst sınır KSDler sırasıyla 4,42kPa ve 4,72kPa idi. 2D-SWEde ölçülen KSDler, pSWEden daha yüksekti sırasıyla medyan; min-maks, 4,34kPa; 2,82-6kPa ve 3,86kPa; 2,55 5,78, r0,59, p0,001. KSD ile yaş arasında düşük düzeyde anlamlı pozitif korelasyon saptandı r0,267; p0,006. Fakat karaciğer büyüklüğü, cinsiyet, VKİ ve biyokimyasal belirteçler ile KDS arasında anlamlı ilişki saptanmadı. Sonuç 8-18 yaş arası sağlıklı çocuklarda ortalama karaciğer sertliği referans değerleri, Philips Epiq Elite ultrason cihazı ile yapılan ölçümlerde, pSWE yöntemi ile 4,040,84kPa ve 2D-SWE yöntemi ile 4,410,71kPa olarak bulundu. Bu referans değerleri, kronik karaciğer hastalıklarında karaciğer parankiminin değerlendirilmesinde SWE yönteminin daha etkin kullanılmasına yardımcı olacaktır.

Makale detayları

EVALUATION OF LIVER ELASTICITY USING pSWE AND 2D-SWE TECHNIQUES IN HEALTHY CHILDREN

Yazarlar:

Hüseyin Aydın | Fatma İssi

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Clinical Sciences

Dergi:

Medical Journal of Süleyman Demirel University Vol.30 Issue 1, pp.69-77

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285089

pISSN:

1300-7416

Children

liver stiffness

ultrasound

shear wave elastography

two-dimensional shear wave imaging

Çocuk

karaciğer sertliği

ultrason

shear wave elastografi

iki boyutlu-shear wave elastografi.

Sayı

Makale detayları

Yazarlar: Hüseyin Aydın | Fatma İssi

Yayıncı: Süleyman Demirel University

Ana Başlıklar: Clinical Sciences

Dergi: Medical Journal of Süleyman Demirel University Vol.30 Issue 1, pp.69-77

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001285089

pISSN: 1300-7416

Sayı

Yazarlar:

Hüseyin Aydın | Fatma İssi

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Clinical Sciences

Dergi:

Medical Journal of Süleyman Demirel University Vol.30 Issue 1, pp.69-77

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285089

pISSN:

1300-7416