Phytochemical Analysis and In vitro Bioactivity Study of Methanol Extract of Byttneria pilosa (Family: Malvaceae)

N.A.

Makale detayları

Phytochemical Analysis and In vitro Bioactivity Study of Methanol Extract of Byttneria pilosa (Family: Malvaceae)

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 1, pp.173-184

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001345949

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Despite numerous promising traditional medicinal applications of Byttneria pilosa Malvaceae, it has largely been unexplored. In this study, the extensive biological and chemical investigation on the aerial part of Byttenria pilosa led to the isolation of saturated aliphatic hydrocarbon having two hydroxyl groups. The antioxidant properties of methanol MeOH extract of Byttneria pilosa MEBP were determined with regard to DPPH free radical scavenging capacity quantitative and qualitative antioxidant properties, Total Phenolic Content TPC, Total Flavonoid Content TFC, and Total Tannin Content TTC. Disc diffusion technique was used to assess the antibacterial activity of methanol extract of B. pilosa. In vitro blood coagulation activity of MEBP was measured by widely used prothrombin time test also called the pro test or PT test. Isolation of pure compounds was done through Thin Layer Chromatography TLC and Column Chromatography CC followed by some detection methods such as NMR and Mass spectroscopy. Phytochemical analysis showed that phenolic hydroxylated compounds were present in B. pilosa which were also responsible for observed bioactivities i.e. antioxidant, antibacterial and blood coagulation activity. The possible structure of the isolated compound was illuminated by meticulous interpretation of spectroscopic data, comprising MS and NMR data. The isolated compound was 2,4,4,7-tetramethyloctane-3,5-diol Molecular formula C12H24O2 and Molecular mass 202 or 2,2,4,6,6-pentamethylheptane-3,5-diol Molecular formula- C12H24O2 and MW-202. The present findings show that B. pilosa possesses significant antioxidant and blood coagulation activity. It was confirmed that the isolated compound could be an aliphatic hydroxylated saturated compound having a molecular formula of C12H26O2 Molecular mass 202.

 Despite numerous promising traditional medicinal applications of Byttneria pilosa Malvaceae, it has largely been unexplored. In this study, the extensive biological and chemical investigation on the aerial part of Byttenria pilosa led to the isolation of saturated aliphatic hydrocarbon having two hydroxyl groups. The antioxidant properties of methanol MeOH extract of Byttneria pilosa MEBP were determined with regard to DPPH free radical scavenging capacity quantitative and qualitative antioxidant properties, Total Phenolic Content TPC, Total Flavonoid Content TFC, and Total Tannin Content TTC. Disc diffusion technique was used to assess the antibacterial activity of methanol extract of B. pilosa. In vitro blood coagulation activity of MEBP was measured by widely used prothrombin time test also called the pro test or PT test. Isolation of pure compounds was done through Thin Layer Chromatography TLC and Column Chromatography CC followed by some detection methods such as NMR and Mass spectroscopy. Phytochemical analysis showed that phenolic hydroxylated compounds were present in B. pilosa which were also responsible for observed bioactivities i.e. antioxidant, antibacterial and blood coagulation activity. The possible structure of the isolated compound was illuminated by meticulous interpretation of spectroscopic data, comprising MS and NMR data. The isolated compound was 2,4,4,7-tetramethyloctane-3,5-diol Molecular formula C12H24O2 and Molecular mass 202 or 2,2,4,6,6-pentamethylheptane-3,5-diol Molecular formula- C12H24O2 and MW-202. The present findings show that B. pilosa possesses significant antioxidant and blood coagulation activity. It was confirmed that the isolated compound could be an aliphatic hydroxylated saturated compound having a molecular formula of C12H26O2 Molecular mass 202.

 Despite numerous promising traditional medicinal applications of Byttneria pilosa Malvaceae, it has largely been unexplored. In this study, the extensive biological and chemical investigation on the aerial part of Byttenria pilosa led to the isolation of saturated aliphatic hydrocarbon having two hydroxyl groups. The antioxidant properties of methanol MeOH extract of Byttneria pilosa MEBP were determined with regard to DPPH free radical scavenging capacity quantitative and qualitative antioxidant properties, Total Phenolic Content TPC, Total Flavonoid Content TFC, and Total Tannin Content TTC. Disc diffusion technique was used to assess the antibacterial activity of methanol extract of B. pilosa. In vitro blood coagulation activity of MEBP was measured by widely used prothrombin time test also called the pro test or PT test. Isolation of pure compounds was done through Thin Layer Chromatography TLC and Column Chromatography CC followed by some detection methods such as NMR and Mass spectroscopy. Phytochemical analysis showed that phenolic hydroxylated compounds were present in B. pilosa which were also responsible for observed bioactivities i.e. antioxidant, antibacterial and blood coagulation activity. The possible structure of the isolated compound was illuminated by meticulous interpretation of spectroscopic data, comprising MS and NMR data. The isolated compound was 2,4,4,7-tetramethyloctane-3,5-diol Molecular formula C12H24O2 and Molecular mass 202 or 2,2,4,6,6-pentamethylheptane-3,5-diol Molecular formula- C12H24O2 and MW-202. The present findings show that B. pilosa possesses significant antioxidant and blood coagulation activity. It was confirmed that the isolated compound could be an aliphatic hydroxylated saturated compound having a molecular formula of C12H26O2 Molecular mass 202.

 Despite numerous promising traditional medicinal applications of Byttneria pilosa Malvaceae, it has largely been unexplored. In this study, the extensive biological and chemical investigation on the aerial part of Byttenria pilosa led to the isolation of saturated aliphatic hydrocarbon having two hydroxyl groups. The antioxidant properties of methanol MeOH extract of Byttneria pilosa MEBP were determined with regard to DPPH free radical scavenging capacity quantitative and qualitative antioxidant properties, Total Phenolic Content TPC, Total Flavonoid Content TFC, and Total Tannin Content TTC. Disc diffusion technique was used to assess the antibacterial activity of methanol extract of B. pilosa. In vitro blood coagulation activity of MEBP was measured by widely used prothrombin time test also called the pro test or PT test. Isolation of pure compounds was done through Thin Layer Chromatography TLC and Column Chromatography CC followed by some detection methods such as NMR and Mass spectroscopy. Phytochemical analysis showed that phenolic hydroxylated compounds were present in B. pilosa which were also responsible for observed bioactivities i.e. antioxidant, antibacterial and blood coagulation activity. The possible structure of the isolated compound was illuminated by meticulous interpretation of spectroscopic data, comprising MS and NMR data. The isolated compound was 2,4,4,7-tetramethyloctane-3,5-diol Molecular formula C12H24O2 and Molecular mass 202 or 2,2,4,6,6-pentamethylheptane-3,5-diol Molecular formula- C12H24O2 and MW-202. The present findings show that B. pilosa possesses significant antioxidant and blood coagulation activity. It was confirmed that the isolated compound could be an aliphatic hydroxylated saturated compound having a molecular formula of C12H26O2 Molecular mass 202.

Makale detayları

Phytochemical Analysis and In vitro Bioactivity Study of Methanol Extract of Byttneria pilosa (Family: Malvaceae)

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 1, pp.173-184

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001345949

pISSN:

2630-6344

Bytteneria pilosa

Saturated aliphatic hydrocarbon

Antioxidant activity

Antibacterial activity

Blood coagulation activity

Sayı

Makale detayları

Phytochemical Analysis and In vitro Bioactivity Study of Methanol Extract of Byttneria pilosa (Family: Malvaceae)

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.27 Issue 1, pp.173-184

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001345949

pISSN: 2630-6344

Bytteneria pilosa

Saturated aliphatic hydrocarbon

Antioxidant activity

Antibacterial activity

Blood coagulation activity

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 1, pp.173-184

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001345949

pISSN:

2630-6344