Association Of Eosinophil And Total Ige Values With Allergy Test Results In Patients With Atopic Dermatitis

Seda Çevik; Ugur Altas; Zeynep Meva Altaş; Mehmet Yaşar Özkars

Makale detayları

Association Of Eosinophil And Total Ige Values With Allergy Test Results In Patients With Atopic Dermatitis

Yazarlar:

Seda Çevik | Ugur Altas | Zeynep Meva Altaş | Mehmet Yaşar Özkars

Yayıncı:

Kocaeli University

Ana Başlıklar:

Alerji

Dergi:

Acta Medica Nicomedia Vol.7 Issue 3, pp.263-267

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330569

pISSN:

2717-8994

Anahtar kelimeler:

Özet:

 AOBJECTIVES: Atopic dermatitis AD is a chronic, recurrent, allergic inflammatory skin disease that may have a genetic predisposition. Eosinophilia is a common finding in patients with atopy. In our study, we aimed to investigate the relationship between eosinophil and IgE levels and allergy test results in patients with atopic dermatitis. METHODS: In this descriptive study, the files of patients diagnosed with atopic dermatitis and followed up in our Pediatric Allergy and Immunology Clinic between January 2021 and December 2022 were retrospectively reviewed. Age, gender, eosinophil, total IgE and specific IgE for food and inhaled allergens values were analyzed in the study. Skin prick test SPT was also performed in patients who had negative results for allergen-specific IgE. RESULTS: The absolute eosinophil count, eosinophil  and total IgE values of patients sensitized to at least one of the food and aeroallergens were significantly higher than those without allergen sensitization. The cut-off point of total IgE in predicting allergen sensitization was found to be 91.5 by ROC analysis. The sensitivity and specificity values for the cut-off point of total IgE were 73.3 and 72.9. CONCLUSION: In this study, allergen sensitization was detected in 3 out of every 4 AD patients with total IgE and eosinophil values above the cut-off point we analyzed. Accordingly, we think that total IgE and eosinophil values are successful in predicting allergen sensitization. In clinics where specific IgE or SPT cannot be performed, eosinophil and total IgE values in whole blood will be useful for preliminary diagnosis.

 AOBJECTIVES: Atopic dermatitis AD is a chronic, recurrent, allergic inflammatory skin disease that may have a genetic predisposition. Eosinophilia is a common finding in patients with atopy. In our study, we aimed to investigate the relationship between eosinophil and IgE levels and allergy test results in patients with atopic dermatitis. METHODS: In this descriptive study, the files of patients diagnosed with atopic dermatitis and followed up in our Pediatric Allergy and Immunology Clinic between January 2021 and December 2022 were retrospectively reviewed. Age, gender, eosinophil, total IgE and specific IgE for food and inhaled allergens values were analyzed in the study. Skin prick test SPT was also performed in patients who had negative results for allergen-specific IgE. RESULTS: The absolute eosinophil count, eosinophil  and total IgE values of patients sensitized to at least one of the food and aeroallergens were significantly higher than those without allergen sensitization. The cut-off point of total IgE in predicting allergen sensitization was found to be 91.5 by ROC analysis. The sensitivity and specificity values for the cut-off point of total IgE were 73.3 and 72.9. CONCLUSION: In this study, allergen sensitization was detected in 3 out of every 4 AD patients with total IgE and eosinophil values above the cut-off point we analyzed. Accordingly, we think that total IgE and eosinophil values are successful in predicting allergen sensitization. In clinics where specific IgE or SPT cannot be performed, eosinophil and total IgE values in whole blood will be useful for preliminary diagnosis.

 AOBJECTIVES: Atopic dermatitis AD is a chronic, recurrent, allergic inflammatory skin disease that may have a genetic predisposition. Eosinophilia is a common finding in patients with atopy. In our study, we aimed to investigate the relationship between eosinophil and IgE levels and allergy test results in patients with atopic dermatitis. METHODS: In this descriptive study, the files of patients diagnosed with atopic dermatitis and followed up in our Pediatric Allergy and Immunology Clinic between January 2021 and December 2022 were retrospectively reviewed. Age, gender, eosinophil, total IgE and specific IgE for food and inhaled allergens values were analyzed in the study. Skin prick test SPT was also performed in patients who had negative results for allergen-specific IgE. RESULTS: The absolute eosinophil count, eosinophil  and total IgE values of patients sensitized to at least one of the food and aeroallergens were significantly higher than those without allergen sensitization. The cut-off point of total IgE in predicting allergen sensitization was found to be 91.5 by ROC analysis. The sensitivity and specificity values for the cut-off point of total IgE were 73.3 and 72.9. CONCLUSION: In this study, allergen sensitization was detected in 3 out of every 4 AD patients with total IgE and eosinophil values above the cut-off point we analyzed. Accordingly, we think that total IgE and eosinophil values are successful in predicting allergen sensitization. In clinics where specific IgE or SPT cannot be performed, eosinophil and total IgE values in whole blood will be useful for preliminary diagnosis.

 Giriş: Atopik dermatit AD, genetik yatkınlık gösterebilen kronik, tekrarlayan, alerjik inflamatuar bir cilt hastalığıdır. Eozinofili, atopi hastalarında yaygın bir bulgudur. Çalışmamızda, atopik dermatit tanılı hastalarda eozinofil ve IgE değerlerinin alerji test sonuçları ile olan ilişkisini incelemeyi amaçladık. Method: Tanımlayıcı tipte olan çalışmada; Ocak 2021- Aralık 2022 tarihleri arasında atopik dermatit tanısı olan ve Çocuk Alerji ve İmmünoloji Kliniğimizde takipli hastaların dosyaları retrospektif olarak incelendi. Çalışmada yaş, cinsiyet, eozinofil, total IgE ve spesifik IgE gıda ve inhaler alerjenler için değerleri analiz edilmiştir. Hastalarda gıda ve aeroallerjenleri tespit etmek için alerjen spesifik IgE testi yapılmıştır. Alerjen spesifik IgE testi negatif olan hastalara deri prick testi de uygulanmıştır. Bulgular: Besin ve aeroalerjenlerin en az birisi için duyarlılığı olan hastaların mutlak eozinofil sayısı, eozinofil  ve total IgE değerleri alerjen duyarlılığı olmayanlara göre anlamlı olarak daha yüksekti. Hastaların total IgE değerlerinin alerjen duyarlılığını öngörme kapasitesi için ROC analizi yapıldı. Yapılan ROC analizi ile total IgEnin alerjen duyarlılığını öngörmedeki kesim noktası 91,5 olarak bulundu. Total IgEnin kesim noktası için sensitivite ve spesifite değerleri 73,3 ve 72,9 bulundu. Sonuç: Çalışmada, total IgE ve eozinofil değerleri analiz ettiğimiz kesim noktasının üzerinde olan yaklaşık her 4 AD hastasının 3ünün 72,2 alerjen duyarlılığı tespit edildi. Buna göre total IgE ve eozinofil değerlerinin alerjen duyarlılığını öngörmede başarılı olduğunu düşünmekteyiz. Spesifik IgE veya deri prick testi bakılamayan kliniklerde ön tanı açısından tam kanda bakılan eozinofil ve total IgE değerleri faydalı olacaktır.

Makale detayları

Association Of Eosinophil And Total Ige Values With Allergy Test Results In Patients With Atopic Dermatitis

Yazarlar:

Seda Çevik | Ugur Altas | Zeynep Meva Altaş | Mehmet Yaşar Özkars

Yayıncı:

Kocaeli University

Ana Başlıklar:

Alerji

Dergi:

Acta Medica Nicomedia Vol.7 Issue 3, pp.263-267

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330569

pISSN:

2717-8994

eosinophils

ROC analysis

Total IgEeozinofil

ROC analizi

Total IgE

Sayı

Makale detayları

Association Of Eosinophil And Total Ige Values With Allergy Test Results In Patients With Atopic Dermatitis

Yazarlar: Seda Çevik | Ugur Altas | Zeynep Meva Altaş | Mehmet Yaşar Özkars

Yayıncı: Kocaeli University

Ana Başlıklar: Alerji

Dergi: Acta Medica Nicomedia Vol.7 Issue 3, pp.263-267

Belge Tipi: Makale

Yayın Tarihi: 10/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001330569

pISSN: 2717-8994

eosinophils

ROC analysis

Total IgEeozinofil

ROC analizi

Total IgE

Sayı

Yazarlar:

Seda Çevik | Ugur Altas | Zeynep Meva Altaş | Mehmet Yaşar Özkars

Yayıncı:

Kocaeli University

Ana Başlıklar:

Alerji

Dergi:

Acta Medica Nicomedia Vol.7 Issue 3, pp.263-267

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330569

pISSN:

2717-8994