Rh Subgroups and Kell Antigens in Patients With Thalassemia and in Donors in Turkey

Duran CANATAN

Makale detayları

Rh Subgroups and Kell Antigens in Patients With Thalassemia and in Donors in Turkey

Yazarlar:

Duran CANATAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 2, pp.155-158

Belge Tipi:

Makale

Yayın Tarihi:

1/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000758082

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Alloimmunization can be a significant complication of transfusion therapy in patients with thalassemia and hemoglobinopathies. The aim of this study was to investigate Rh and Kell antigens in patients with thalassemia major and in donors in Turkey. A total of 3061 donors and 155 thalassemic patients from three different blood donation centers in Turkey were the subjects of this study. Antigens of Rh and Kell were determined using the Diamed Gel Test. The results of Rh haplotype tests in the thalassemic patients were 40.0% R1, 35.8% r, 19.8% R2, 2.8% R0, 1.4% r'; and in the donors were 46.7% R1, 33.8 %r, 16.1% R2, 2.6% R0, 0.5 % r1, 0.13% Rz and 0.08 % r'. The results of phenotype testing in the patients were 37.4 % R1r, 35.7% R1R2, 10.3% rr, 6.6 % R2r, 5.7% R1R1, 2.8 % R2R2, 2.8 % R0R0 and 0.8 rr'. The phenotypes of th donors were 33 % R1r, 30.5% R1R2, 21.8% R1R1, 11.6% rr, 10.4% R2r, 2.7% R0R0, 2.4% R2R2, 0.9% rr' and 0.03% RzRz. Of the Rh haplotype R1 was the most common in both groups; constituting 46.7% and 40.0%. R1r was also the most common Rh phenotype in both groups; constituting 37.4% and 33%. The incidence of Kell antigens in the donors and patients was 5.42 and 3.77% respectively. There was no significant difference in the haplotypes and phenotypes of these thalassemic patients and donors in Turkey.

 

Alloimmunization can be a significant complication of transfusion therapy in patients with thalassemia and hemoglobinopathies. The aim of this study was to investigate Rh and Kell antigens in patients with thalassemia major and in donors in Turkey. A total of 3061 donors and 155 thalassemic patients from three different blood donation centers in Turkey were the subjects of this study. Antigens of Rh and Kell were determined using the Diamed Gel Test. The results of Rh haplotype tests in the thalassemic patients were 40.0% R1, 35.8% r, 19.8% R2, 2.8% R0, 1.4% r'; and in the donors were 46.7% R1, 33.8 %r, 16.1% R2, 2.6% R0, 0.5 % r1, 0.13% Rz and 0.08 % r'. The results of phenotype testing in the patients were 37.4 % R1r, 35.7% R1R2, 10.3% rr, 6.6 % R2r, 5.7% R1R1, 2.8 % R2R2, 2.8 % R0R0 and 0.8 rr'. The phenotypes of th donors were 33 % R1r, 30.5% R1R2, 21.8% R1R1, 11.6% rr, 10.4% R2r, 2.7% R0R0, 2.4% R2R2, 0.9% rr' and 0.03% RzRz. Of the Rh haplotype R1 was the most common in both groups; constituting 46.7% and 40.0%. R1r was also the most common Rh phenotype in both groups; constituting 37.4% and 33%. The incidence of Kell antigens in the donors and patients was 5.42 and 3.77% respectively. There was no significant difference in the haplotypes and phenotypes of these thalassemic patients and donors in Turkey.

Makale detayları

Rh Subgroups and Kell Antigens in Patients With Thalassemia and in Donors in Turkey

Yazarlar:

Duran CANATAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 2, pp.155-158

Belge Tipi:

Makale

Yayın Tarihi:

1/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000758082

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Blood subgroups

thalassemia

donors.

Sayı

Makale detayları

Rh Subgroups and Kell Antigens in Patients With Thalassemia and in Donors in Turkey

Yazarlar: Duran CANATAN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 1999 Vol.29 Issue 2, pp.155-158

Belge Tipi: Makale

Yayın Tarihi: 1/1999

Belge Dili: Türkçe

Document ID (Org No.): 2000758082

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Blood subgroups

thalassemia

donors.

Sayı

Yazarlar:

Duran CANATAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 1999 Vol.29 Issue 2, pp.155-158

Belge Tipi:

Makale

Yayın Tarihi:

1/1999

Belge Dili:

Türkçe

Document ID (Org No.):

2000758082

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144