COURSE OF PAPILLARY THYROID CARCINOMA DIAGNOSED IN CHILDHOOD AND ADOLESCENCE AND FOLLOWED THROUGH ADULTHOOD: EXPERIENCE FROM A TERTIARY REFERRAL CENTER

Hülya Hacişahinoğulları; Elif İnan Balcı; Ahmet Yalın İşcan; Gülşah Yenidünya Yalın; Özlem Soyluk Selçukbiricik; İsmail Cem Sormaz; Firdevs Baş; Ayşe Kubat Üzüm; Yasemin Giles Şenyürek; Şükran Poyrazoğlu; Nurdan Gül

Makale detayları

COURSE OF PAPILLARY THYROID CARCINOMA DIAGNOSED IN CHILDHOOD AND ADOLESCENCE AND FOLLOWED THROUGH ADULTHOOD: EXPERIENCE FROM A TERTIARY REFERRAL CENTER

Yazarlar:

Hülya Hacişahinoğulları | Elif İnan Balcı | Ahmet Yalın İşcan | Gülşah Yenidünya Yalın | Özlem Soyluk Selçukbiricik | İsmail Cem Sormaz | Firdevs Baş | Ayşe Kubat Üzüm | Yasemin Giles Şenyürek | Şükran Poyrazoğlu | Nurdan Gül

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.86 Issue 4, pp.282-287

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001310895

pISSN:

1305-6441

Anahtar kelimeler:

Özet:

 Objective: Differentiated thyroid cancer accounts for 1.5 of all pediatric malignancies. Papillary thyroid cancer PTC is the most common subtype and is associated with more advanced disease at diagnosis compared to adults. This study aimed to identify long-term outcomes of pediatric PTC. Material and Method: Records of 30 patients with PTC diagnosed in childhood and adolescence and followed up at the Istanbul Faculty of Medicine were reviewed retrospectively. Result: The mean age of 30 patients 21 females, 9 males at diagnosis was 14.72.3 years. The mean duration of follow-up was 10.63.8 years. The patients underwent total thyroidectomy n9, total thyroidectomy with central lymph node dissection n9, or total thyroidectomy with central and lateral lymph node dissection n12. The mean tumor diameter was 1.61.5 cm and was microcarcinoma in 12 of the patients. There were five patients with T2 and two patients with T3 disease. At diagnosis, half of the patients had lymph node metastasis to the neck or upper mediastinum N1a5, N1b10, and two also had lung metastasis. Post-operative radioactive iodine RAI treatment was administered to 22 patients, the median cumulative dose was 150 mCi range 50 to 1100. Sixteen patients had excellent responses following single n13 or multiple 2 for persistent and 1 for recurring disease after 8.3 years RAI administrations. The remaining three patients had structural incomplete and three had indeterminate responses. Conclusion: Although PTC presented at a more advanced stage in childhood and adolescence, the response to treatment was fairly good with appropriate management.

 Objective: Differentiated thyroid cancer accounts for 1.5 of all pediatric malignancies. Papillary thyroid cancer PTC is the most common subtype and is associated with more advanced disease at diagnosis compared to adults. This study aimed to identify long-term outcomes of pediatric PTC. Material and Method: Records of 30 patients with PTC diagnosed in childhood and adolescence and followed up at the Istanbul Faculty of Medicine were reviewed retrospectively. Result: The mean age of 30 patients 21 females, 9 males at diagnosis was 14.72.3 years. The mean duration of follow-up was 10.63.8 years. The patients underwent total thyroidectomy n9, total thyroidectomy with central lymph node dissection n9, or total thyroidectomy with central and lateral lymph node dissection n12. The mean tumor diameter was 1.61.5 cm and was microcarcinoma in 12 of the patients. There were five patients with T2 and two patients with T3 disease. At diagnosis, half of the patients had lymph node metastasis to the neck or upper mediastinum N1a5, N1b10, and two also had lung metastasis. Post-operative radioactive iodine RAI treatment was administered to 22 patients, the median cumulative dose was 150 mCi range 50 to 1100. Sixteen patients had excellent responses following single n13 or multiple 2 for persistent and 1 for recurring disease after 8.3 years RAI administrations. The remaining three patients had structural incomplete and three had indeterminate responses. Conclusion: Although PTC presented at a more advanced stage in childhood and adolescence, the response to treatment was fairly good with appropriate management.

 Objective: Differentiated thyroid cancer accounts for 1.5 of all pediatric malignancies. Papillary thyroid cancer PTC is the most common subtype and is associated with more advanced disease at diagnosis compared to adults. This study aimed to identify long-term outcomes of pediatric PTC. Material and Method: Records of 30 patients with PTC diagnosed in childhood and adolescence and followed up at the Istanbul Faculty of Medicine were reviewed retrospectively. Result: The mean age of 30 patients 21 females, 9 males at diagnosis was 14.72.3 years. The mean duration of follow-up was 10.63.8 years. The patients underwent total thyroidectomy n9, total thyroidectomy with central lymph node dissection n9, or total thyroidectomy with central and lateral lymph node dissection n12. The mean tumor diameter was 1.61.5 cm and was microcarcinoma in 12 of the patients. There were five patients with T2 and two patients with T3 disease. At diagnosis, half of the patients had lymph node metastasis to the neck or upper mediastinum N1a5, N1b10, and two also had lung metastasis. Post-operative radioactive iodine RAI treatment was administered to 22 patients, the median cumulative dose was 150 mCi range 50 to 1100. Sixteen patients had excellent responses following single n13 or multiple 2 for persistent and 1 for recurring disease after 8.3 years RAI administrations. The remaining three patients had structural incomplete and three had indeterminate responses. Conclusion: Although PTC presented at a more advanced stage in childhood and adolescence, the response to treatment was fairly good with appropriate management.

 Amaç: Diferansiye tiroid kanseri, tüm pediatrik malignitelerin 1,5ini oluşturur. Papiller tiroid kanseri PTK en sık görülen alt tiptir ve tanı anında hastalık evresi erişkinlere kıyasla daha ileridir. Bu çalışmanın amacı, pediatrik PTKnin uzun vadeli sonuçlarını değerlendirmekti. Gereç ve Yöntem: İstanbul Tıp Fakültesinde takip edilen çocukluk ve adölesan döneminde PTK tanısı konulan 30 hastanın retrospektif olarak verileri incelendi. Bulgular: Otuz hastanın 21 kadın, 9 erkek tanı anındaki ortalamayaşı 14,72,3 idi. Ortalama takip süresi 10,63,8 yıldı. Dokuz hastaya total tiroidektomi, dokuz hastaya santral lenf nodu diseksiyonu ile total tiroidektomi, 12 hastaya ise santral ve lateral lenf nodu diseksiyonu ile total tiroidektomi uygulandı. Ortalama tümör çapı 1,61,5 cm idi ve 12 hastada mikrokarsinom saptandı. T2 hastalığı olan beş hasta ve T3 hastalığı olan iki hasta vardı. Tanı sırasında hastaların yarısında boyun veya üst mediastende lenf nodu metastazı N1a5, N1b10, iki hastada da ayrıca akciğer metastazı vardı. Ameliyat sonrası 22 hastaya radyoaktif iyot RAI tedavisi uygulandı, ortanca kümülatif doz 150 mCi aralık 50-1100 idi. Hastaların 13ü tekli doz, 3ü 2 hasta persistan hastalık, 1 hasta 8,3 yıl sonra gelişen nüks hastalık nedeniyle çoklu doz RAI uygulamasının ardından mükemmel yanıt verdi. Kalan üç hastada yapısal inkomplet ve üç hastada indetermine yanıt alındı. Sonuç: PTK çocukluk ve ergenlik döneminde daha ileri evrede ortaya çıksa da uygun hastalık yönetimiyle tedaviye yanıt oldukça iyiydi.

Makale detayları

COURSE OF PAPILLARY THYROID CARCINOMA DIAGNOSED IN CHILDHOOD AND ADOLESCENCE AND FOLLOWED THROUGH ADULTHOOD: EXPERIENCE FROM A TERTIARY REFERRAL CENTER

Yazarlar:

Hülya Hacişahinoğulları | Elif İnan Balcı | Ahmet Yalın İşcan | Gülşah Yenidünya Yalın | Özlem Soyluk Selçukbiricik | İsmail Cem Sormaz | Firdevs Baş | Ayşe Kubat Üzüm | Yasemin Giles Şenyürek | Şükran Poyrazoğlu | Nurdan Gül

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.86 Issue 4, pp.282-287

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001310895

pISSN:

1305-6441

Papillary thyroid cancer

thyroid

pediatric

radioactive iodinePapiller tiroid kanseri

tiroid

pediatrik

radyoaktif iyot

Sayı

Makale detayları

Yazarlar: Hülya Hacişahinoğulları | Elif İnan Balcı | Ahmet Yalın İşcan | Gülşah Yenidünya Yalın | Özlem Soyluk Selçukbiricik | İsmail Cem Sormaz | Firdevs Baş | Ayşe Kubat Üzüm | Yasemin Giles Şenyürek | Şükran Poyrazoğlu | Nurdan Gül

Yayıncı: Istanbul University

Ana Başlıklar: Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi: İstanbul Tıp Fakültesi Dergisi Vol.86 Issue 4, pp.282-287

Belge Tipi: Makale

Yayın Tarihi: 1/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001310895

pISSN: 1305-6441

Sayı

Yazarlar:

Hülya Hacişahinoğulları | Elif İnan Balcı | Ahmet Yalın İşcan | Gülşah Yenidünya Yalın | Özlem Soyluk Selçukbiricik | İsmail Cem Sormaz | Firdevs Baş | Ayşe Kubat Üzüm | Yasemin Giles Şenyürek | Şükran Poyrazoğlu | Nurdan Gül

Yayıncı:

Istanbul University

Ana Başlıklar:

Sağlık Hizmetleri ve Sistemleri (Diğer)

Dergi:

İstanbul Tıp Fakültesi Dergisi Vol.86 Issue 4, pp.282-287

Belge Tipi:

Makale

Yayın Tarihi:

1/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001310895

pISSN:

1305-6441