Does intratympanic Mesna application prevent cholesteatoma? An experimental study on rats

Bilal SİZER; Songül DEMİR; Aylin GÜL

doi:https://doi.org/10.28982/josam.974266

Makale detayları

Does intratympanic Mesna application prevent cholesteatoma? An experimental study on rats

Yazarlar:

Bilal SİZER | Songül DEMİR | Aylin GÜL

Yayıncı:

Fatih BAŞAK

Ana Başlıklar:

Cerrahi ve ilgili tıbbi uzmanlıklar

Dergi:

Journal of Surgery and Medicine 2021 Vol.5 Issue 10, pp.1050-1053

Belge Tipi:

Makale

Yayın Tarihi:

9/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000498433

Sıklık:

Aylık

eISSN:

2602-2079

DOI:

https://doi.org/10.28982/josam.974266

Özet:

 

Background/Aim: Cholesteatoma is an invasive and destructive disease, responsible for most of the complications related to chronic otitis media. The only effective treatment is surgical excision. Researching medical treatment alternatives can bring a new perspective to the treatment of this disease. This study aimed to investigate the effect of Mesna on otitis media and cholesteatoma induced by propylene glycol on an experimental animal model.
Methods: The study was designed to consist of sixteen Wistar albino rats, with their right ears being the control group and the left ears being the experiment group. Fifty percent propylene glycol, gentamicin sulfate, and physiologic saltwater were administered to the right ear, and 50% propylene glycol, gentamicin sulfate, and 20% Mesna were administered to the left ear through intratympanic injections on days 1, 3, 8, 15, and 21. The rats were sacrificed 45 days after the first injection and underwent histopathological examination.
Results: Cholesteatoma and fibrosis were less common in the experimental group. In the study group, the average and maximum thicknesses of the tympanic membranes (P=0.008) and the minimum thicknesses of the tympanic bulla (P=0.019) were significantly less than those of the control group.
Conclusion: In the experimental cholesteatoma model created in rats, Mesna, administered intratympanically, was seen to completely prevent the formation of cholesteatoma. However, histopathological examination revealed that although present, cholesteatoma formation and fibrosis were significantly less in the experimental group.

Makale detayları

Does intratympanic Mesna application prevent cholesteatoma? An experimental study on rats

Yazarlar: Bilal SİZER | Songül DEMİR | Aylin GÜL

Yayıncı: Fatih BAŞAK

Ana Başlıklar: Cerrahi ve ilgili tıbbi uzmanlıklar

Dergi: Journal of Surgery and Medicine 2021 Vol.5 Issue 10, pp.1050-1053

Belge Tipi: Makale

Yayın Tarihi: 9/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000498433

Sıklık: Aylık

eISSN: 2602-2079

DOI: https://doi.org/10.28982/josam.974266

Sayı

Yazarlar:

Bilal SİZER | Songül DEMİR | Aylin GÜL

Yayıncı:

Fatih BAŞAK

Ana Başlıklar:

Cerrahi ve ilgili tıbbi uzmanlıklar

Dergi:

Journal of Surgery and Medicine 2021 Vol.5 Issue 10, pp.1050-1053

Belge Tipi:

Makale

Yayın Tarihi:

9/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000498433

Sıklık:

Aylık

eISSN:

2602-2079

DOI:

https://doi.org/10.28982/josam.974266