Investigation of serum macrophage migration inhibitor factor and monocyte chemotactic protein-1 levels in irritable bowel syndrome

Feti TÜLÜBAŞ; Mustafa ORAN; Rafet METE; Filiz TURAN; Ahsen YILMAZ; Zeynep Deniz YILDIZ; Ahmet GÜREL

Makale detayları

Investigation of serum macrophage migration inhibitor factor and monocyte chemotactic protein-1 levels in irritable bowel syndrome

Yazarlar:

Feti TÜLÜBAŞ | Mustafa ORAN | Rafet METE | Filiz TURAN | Ahsen YILMAZ | Zeynep Deniz YILDIZ | Ahmet GÜREL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 6, pp.967-971

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000752962

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Irritable bowel syndrome (IBS), a functional disorder of the bowel, has been thought to result from immune activation. The aim of this study was to evaluate macrophage migration inhibitory factor (MMIF) and monocyte chemotactic protein-1 (MCP-1) levels in IBS patients.   Materials and methods: We enrolled 30 IBS patients and 30 healthy controls. The MMIF and MCP-1 levels of all patients and controls were detected using commercial enzyme-linked immunosorbent assay kits.  Results: Serum MMIF and MCP-1 levels were markedly higher in IBS patients than in controls. White blood cell, neutrophil, lymphocyte, monocyte, eosinophil, and basophil counts did not differ significantly between groups.  Conclusion: These results show that alterations in MMIF and MCP-1 affect the proinflammatory process. They also suggest that MMIF and MCP-1 may play a substantial role in IBS.

 

Irritable bowel syndrome (IBS), a functional disorder of the bowel, has been thought to result from immune activation. The aim of this study was to evaluate macrophage migration inhibitory factor (MMIF) and monocyte chemotactic protein-1 (MCP-1) levels in IBS patients.   Materials and methods: We enrolled 30 IBS patients and 30 healthy controls. The MMIF and MCP-1 levels of all patients and controls were detected using commercial enzyme-linked immunosorbent assay kits.  Results: Serum MMIF and MCP-1 levels were markedly higher in IBS patients than in controls. White blood cell, neutrophil, lymphocyte, monocyte, eosinophil, and basophil counts did not differ significantly between groups.  Conclusion: These results show that alterations in MMIF and MCP-1 affect the proinflammatory process. They also suggest that MMIF and MCP-1 may play a substantial role in IBS.

Makale detayları

Investigation of serum macrophage migration inhibitor factor and monocyte chemotactic protein-1 levels in irritable bowel syndrome

Yazarlar:

Feti TÜLÜBAŞ | Mustafa ORAN | Rafet METE | Filiz TURAN | Ahsen YILMAZ | Zeynep Deniz YILDIZ | Ahmet GÜREL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 6, pp.967-971

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000752962

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Irritable bowel syndrome

macrophage migration inhibitory factor

monocyte chemotactic protein

inflammation

Sayı

Makale detayları

Investigation of serum macrophage migration inhibitor factor and monocyte chemotactic protein-1 levels in irritable bowel syndrome

Yazarlar: Feti TÜLÜBAŞ | Mustafa ORAN | Rafet METE | Filiz TURAN | Ahsen YILMAZ | Zeynep Deniz YILDIZ | Ahmet GÜREL

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2014 Vol.44 Issue 6, pp.967-971

Belge Tipi: Makale

Yayın Tarihi: 5/2014

Belge Dili: Türkçe

Document ID (Org No.): 2000752962

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Irritable bowel syndrome

macrophage migration inhibitory factor

monocyte chemotactic protein

inflammation

Sayı

Yazarlar:

Feti TÜLÜBAŞ | Mustafa ORAN | Rafet METE | Filiz TURAN | Ahsen YILMAZ | Zeynep Deniz YILDIZ | Ahmet GÜREL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2014 Vol.44 Issue 6, pp.967-971

Belge Tipi:

Makale

Yayın Tarihi:

5/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000752962

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144