Efficient Synthetic Methodology for the Synthesis of New Bicyclic Pyrrole Derivatives

Nuriye Tuna Subaşı

Makale detayları

Efficient Synthetic Methodology for the Synthesis of New Bicyclic Pyrrole Derivatives

Yazarlar:

Nuriye Tuna Subaşı

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

İnorganik Kimya (Diğer)

Dergi:

Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi Vol.25 Issue 4, pp.720-728

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001354995

pISSN:

2149-3367

Anahtar kelimeler:

Özet:

 A series of novel bicyclic pyrrole derivatives pyrrolizine and indolizine like structures were successfully synthesized in a two-step procedure. Starting from dimethoxytetrahydrofuran and amino acid esters, unsubstituted pyrrole derivatives and 1,2-disubstituted and 1,2,4-trisubstituted pyrrole derivatives were synthesized without racemization through the reaction of amino acid esters with suitable chloroenones. Subsequently, these substituted and unsubstituted pyrrole derivatives were subjected to cyclization reactions with BBr₃ boron tribromide, resulting in the formation of new bicyclic pyrrole derivatives with good yields. This synthesis strategy stands out by providing a broader substrate scope and improved yields compared to existing methods in the literature..

 A series of novel bicyclic pyrrole derivatives pyrrolizine and indolizine like structures were successfully synthesized in a two-step procedure. Starting from dimethoxytetrahydrofuran and amino acid esters, unsubstituted pyrrole derivatives and 1,2-disubstituted and 1,2,4-trisubstituted pyrrole derivatives were synthesized without racemization through the reaction of amino acid esters with suitable chloroenones. Subsequently, these substituted and unsubstituted pyrrole derivatives were subjected to cyclization reactions with BBr₃ boron tribromide, resulting in the formation of new bicyclic pyrrole derivatives with good yields. This synthesis strategy stands out by providing a broader substrate scope and improved yields compared to existing methods in the literature..

 A series of novel bicyclic pyrrole derivatives pyrrolizine and indolizine like structures were successfully synthesized in a two-step procedure. Starting from dimethoxytetrahydrofuran and amino acid esters, unsubstituted pyrrole derivatives and 1,2-disubstituted and 1,2,4-trisubstituted pyrrole derivatives were synthesized without racemization through the reaction of amino acid esters with suitable chloroenones. Subsequently, these substituted and unsubstituted pyrrole derivatives were subjected to cyclization reactions with BBr₃ boron tribromide, resulting in the formation of new bicyclic pyrrole derivatives with good yields. This synthesis strategy stands out by providing a broader substrate scope and improved yields compared to existing methods in the literature..

 Bir dizi yeni bisiklik pirol türevi pirolizin ve indolizin benzeri yapılar iki aşamalı bir prosedürle başarıyla sentezlenmiştir. Dimetoksitetrahidrofuran ve amino asit esterlerinden başlayarak, sübstitüe olmayan pirol türevleri ve amino asit esterlerinin uygun kloroenonlarla muamelesi ile 1,2-disübstitüe ve 1,2,4-trisübstitüe pirol türevleri rasemizasyon olmaksızın sentezlendi. Daha sonra çalışmaya, sentezlenen bu sübstitüe ve sübstitüe olmayan pirol türevlerinin BBr3 ile siklizasyon reaksiyonu ile devam edilerek yeni bisiklik pirol türevleri iyi verimle elde edildi.

Makale detayları

Efficient Synthetic Methodology for the Synthesis of New Bicyclic Pyrrole Derivatives

Yazarlar:

Nuriye Tuna Subaşı

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

İnorganik Kimya (Diğer)

Dergi:

Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi Vol.25 Issue 4, pp.720-728

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001354995

pISSN:

2149-3367

Substituted pyrrole derivative

Chloroenone

BBr3 cyclisation

Indolizine

PyrrolizineSübstitüe pirol türevi

Kloroenon

BBr3 siklizasyonu

İndolizin

Pirolizin

Sayı

Makale detayları

Yazarlar: Nuriye Tuna Subaşı

Yayıncı: Afyon Kocatepe University

Ana Başlıklar: İnorganik Kimya (Diğer)

Dergi: Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi Vol.25 Issue 4, pp.720-728

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: Türkçe

Document ID (Org No.): 2001354995

pISSN: 2149-3367

Sayı

Yazarlar:

Nuriye Tuna Subaşı

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

İnorganik Kimya (Diğer)

Dergi:

Afyon Kocatepe Üniversitesi Fen Ve Mühendislik Bilimleri Dergisi Vol.25 Issue 4, pp.720-728

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

Türkçe

Document ID (Org No.):

2001354995

pISSN:

2149-3367