Association of the CETP gene TaqIB and D442G polymorphisms with essential  hypertension in the Chinese Mongolian population

Shudong NIU; Xiaoming TAO; Jingping LI; Yongyue LIU; Jian WANG; Mingyu CONG; Keyong ZHANG; WENYU ZHOU; Changchun QIU

Makale detayları

Association of the CETP gene TaqIB and D442G polymorphisms with essential hypertension in the Chinese Mongolian population

Yazarlar:

Shudong NIU | Xiaoming TAO | Jingping LI | Yongyue LIU | Jian WANG | Mingyu CONG | Keyong ZHANG | WENYU ZHOU | Changchun QIU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 2, pp.599-606

Belge Tipi:

Makale

Yayın Tarihi:

3/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751465

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: This study aimed to explore the associations of the cholesteryl ester transfer protein (CETP) gene TaqIB and D442G  polymorphisms with essential hypertension (EH).  Materials and methods: In this case-control study, 883 hypertensive patients and 1044 normal controls were randomly selected from  the Mongolian population of China. Polymerase chain reaction (PCR) and direct sequencing of PCR products were used to identify the  genotypes. Haplotype analysis was performed by estimating the haplotype frequencies using the online SHEsis package.  Results: The distribution frequency of the B2-G haplotype was significantly lower in the EH group than in the control group (0.7% vs.  1.9%, P = 0.001, OR = 0.359 [0.188?0.689]). Subjects with the B2B2 genotype showed significantly lower levels of total cholesterol (TC)  (P < 0.05). When subgrouped by sex, male subjects with the B2B2 genotype showed significantly increased high-density lipoprotein  cholesterol and decreased TC levels (P < 0.05), and those with the B2 allele showed significantly lower triglyceride levels as compared to  the subjects with the B1B1 homozygote (P < 0.05).  Conclusion: TaqIB and D442G polymorphisms of the CETP gene did not independently affect the risk of developing EH in the Chinese  Mongolian population, while the B2-G haplotype obviously decreased the susceptibility to EH. The B2 allele could alter the blood lipid  level and reduce the risk of developing cardiovascular diseases.

Makale detayları

Association of the CETP gene TaqIB and D442G polymorphisms with essential hypertension in the Chinese Mongolian population

Yazarlar: Shudong NIU | Xiaoming TAO | Jingping LI | Yongyue LIU | Jian WANG | Mingyu CONG | Keyong ZHANG | WENYU ZHOU | Changchun QIU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2017 Vol.47 Issue 2, pp.599-606

Belge Tipi: Makale

Yayın Tarihi: 3/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000751465

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Shudong NIU | Xiaoming TAO | Jingping LI | Yongyue LIU | Jian WANG | Mingyu CONG | Keyong ZHANG | WENYU ZHOU | Changchun QIU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 2, pp.599-606

Belge Tipi:

Makale

Yayın Tarihi:

3/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751465

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144