Determination of Anti-genotoxic Properties of Baicalin by Comet Assay

Selçuk ÇEKER; Güleray AĞAR

Makale detayları

Determination of Anti-genotoxic Properties of Baicalin by Comet Assay

Yazarlar:

Selçuk ÇEKER | Güleray AĞAR

Yayıncı:

Ağrı İbrahim Çeçen University

Dergi:

Eastern Anatolian Journal of Science 2021 Vol.7 Issue 1, pp.19-24

Belge Tipi:

Makale

Yayın Tarihi:

5/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000949714

Sıklık:

İki Yıllık

pISSN:

2149-6137

Özet:

 

It has been reported that baicalin (7-glucuronic acid,5,6-dihydroxyflavone; molecular weight= 446.36) has antioxidant, antitoxin and anti-inflammatory properties, antitumor, antiviral, hepatoprotective, antibacterial, anti-inflammatory and antidiarrheal effects. The purpose of the present study is determined the anti-genotoxic and antioxidative effects of baicalin against carbon tetrachloride in the human lymphocytes cell.  For the study, the anti-genotoxic potential of baicalin was investigated by comet assay. In addition, biochemical analysis including superoxide dismutase, catalase activities and malondialdehyde level, were performed. According to the obtained results; when the concentrations were evaluated in terms of reducing the level of DNA damage, it was observed that baicalin gave the best results in the applications of 100 μM concentration. In conclusion, baicalin was determined to exhibit anti-genotoxic activity by virtue of its antioxidant potential, which is the genotoxic effect caused by carbon tetrachloride. Baicalin, an important compound for clinical applications and known to have a short half-life; more successful results can be obtained in treatment with high concentrations and repeated applications.

Makale detayları

Determination of Anti-genotoxic Properties of Baicalin by Comet Assay

Yazarlar: Selçuk ÇEKER | Güleray AĞAR

Yayıncı: Ağrı İbrahim Çeçen University

Dergi: Eastern Anatolian Journal of Science 2021 Vol.7 Issue 1, pp.19-24

Belge Tipi: Makale

Yayın Tarihi: 5/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000949714

Sıklık: İki Yıllık

pISSN: 2149-6137

Sayı

Yazarlar:

Selçuk ÇEKER | Güleray AĞAR

Yayıncı:

Ağrı İbrahim Çeçen University

Dergi:

Eastern Anatolian Journal of Science 2021 Vol.7 Issue 1, pp.19-24

Belge Tipi:

Makale

Yayın Tarihi:

5/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000949714

Sıklık:

İki Yıllık

pISSN:

2149-6137