Isolation, Characterisation and In Silico Toxicity Evaluations of Thiocarbamates, Isothiocyanates, Nitrile, Glucosinolate and Lipids from Moringa oleifera Lam. Seed

Atolani ATOLANİ; Olorundare O.E; Banerjee PRİYANKA; Osin O; Preissner R; Njan A.A

doi:https://doi.org/10.18596/jotcsa.569960

Makale detayları

Isolation, Characterisation and In Silico Toxicity Evaluations of Thiocarbamates, Isothiocyanates, Nitrile, Glucosinolate and Lipids from Moringa oleifera Lam. Seed

Yazarlar:

Atolani ATOLANİ | Olorundare O.E | Banerjee PRİYANKA | Osin O | Preissner R | Njan A.A

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Organik kimya

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry 2020 Vol.7 Issue 1, pp.233-242

Belge Tipi:

Makale

Yayın Tarihi:

2/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000502721

Sıklık:

Üç Aylık

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.569960

Özet:

 


The phytochemical
composition of medicinal plants is responsible for the ethnopharmacological
applications. These phytochemicals vary in plants of same species planted in
various geographical locations. The seed of Moringa
oleifera Lam., a widely consumed multi-medicinal
plant was examined for the bioactive phytochemicals. With the aid of Nuclear
Magnetic Resonance (1H-NMR/13C-NMR) spectrometer, Electrospray
Ionisation Mass Spectrometry (ESI-MS) and Fourier Transform Infrared (FT-IR)
spectroscopy, the phytochemical investigation of the seed of M. oleifera
afforded nine compounds which included niazimicin 1, niazidin 2, glucomoringin
isothiocyanate 3, niazinin acetate
4, niazinin triacetate 5, niazirinin 6, glucotropaeolin 7, triolein 8, trivaccenin 9. The
Gas Chromatography-Mass Spectrometry (GC-MS) analysis of a major oily fraction
revealed the presence of additional ten compounds which include oleic acid
(major), 13-docosenoic acid, stearic acid, p-hydroxybenzyl cyanide, α
-l-rhamnopyranose and other fatty acids/esters. 
This is the first account of a
fully acetylated niazinin (a 4-(2’,3',4’-O-triacetyl-α-L-rhamnosyloxy)benzyl
isothiocyanate) 5 from Moringa oleifera seed. The in
silico toxicity evaluation indicated that most of the isolated compounds are
either immunotoxic, carcinogenic or mutagenic. The result thus obtained could
serve a basis for the pharmacological and toxicological evaluation and
profiling of the seed. The result further implied the need for dosage
regulation of the consumption of the seed.


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Makale detayları

Isolation, Characterisation and In Silico Toxicity Evaluations of Thiocarbamates, Isothiocyanates, Nitrile, Glucosinolate and Lipids from Moringa oleifera Lam. Seed

Yazarlar: Atolani ATOLANİ | Olorundare O.E | Banerjee PRİYANKA | Osin O | Preissner R | Njan A.A

Yayıncı: Turkish Chemical Society

Ana Başlıklar: Organik kimya

Dergi: Journal of the Turkish Chemical Society Section A: Chemistry 2020 Vol.7 Issue 1, pp.233-242

Belge Tipi: Makale

Yayın Tarihi: 2/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000502721

Sıklık: Üç Aylık

eISSN: 2149-0120

DOI: https://doi.org/10.18596/jotcsa.569960

Sayı

Yazarlar:

Atolani ATOLANİ | Olorundare O.E | Banerjee PRİYANKA | Osin O | Preissner R | Njan A.A

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Organik kimya

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry 2020 Vol.7 Issue 1, pp.233-242

Belge Tipi:

Makale

Yayın Tarihi:

2/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000502721

Sıklık:

Üç Aylık

eISSN:

2149-0120

DOI:

https://doi.org/10.18596/jotcsa.569960