Synthesis of neodymium-iron nanoperovskite for sensing applications of an   antiallergic drug

Nada F. ATTA; Mohammad H. BINSABT; Ekram H. EL-ADS; Ahmed GALAL

Makale detayları

Synthesis of neodymium-iron nanoperovskite for sensing applications of an antiallergic drug

Yazarlar:

Nada F. ATTA | Mohammad H. BINSABT | Ekram H. EL-ADS | Ahmed GALAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2017 Vol.41 Issue 4, pp.476-492

Belge Tipi:

Makale

Yayın Tarihi:

7/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000726357

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

A facile route was used for the fabrication of   NdFeO33_{3} (NF) perovskite. The orthorhombic structure of single phase   nanocrystalline NdFeO33_{3} perovskite was confirmed by different   characterization techniques: XRD, FTIR, TEM, BET, SEM, and EDAX. The   nanoperovskite was successfully used as a sensor component with a carbon   paste electrode (CpE) for the determination of ketotifen in pharmaceutical   formulations. Ketotifen, an antiallergic drug, is utilized for the treatment   of asthma attacks, rhinitis, skin allergies, and anaphylaxis. Sodium dodecyl   sulfate (SDS) was employed in a surface assembly mode to improve the   sensitivity of the sensor response. The proposed sensor, NdFeO33_{3} in situ   modified carbon paste electrode in the presence of SDS (NFMCpE-SDS), showed   a higher current response towards ketotifen oxidation compared to other   surfaces. The enhanced signal response is attributed to the catalytic   properties of the sensor and the relative increase in surface area. A linear   relationship between the oxidation peak current and ketotifen concentration   was obtained in the concentration range of 0.8 μμ\mu mol L−1−1^{-1} to 360   μμ\mu mol L−1−1^{-1}. The surface showed long-term stability of 1 month of   operation and the limits of detection and quantification of ketotifen were   2.92 nmol L−1−1^{-1} and 9.71 nmol L−1−1^{-1}, respectively, with high   sensitivity of 311 μμ\mu A/mmol L−1−1^{-1}. The composite electrode proved to   be selective for drug sensing in the presence of different interfering   species and applicable for drug determination in commercial tablets, human   serum, and urine.

Makale detayları

Synthesis of neodymium-iron nanoperovskite for sensing applications of an antiallergic drug

Yazarlar: Nada F. ATTA | Mohammad H. BINSABT | Ekram H. EL-ADS | Ahmed GALAL

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2017 Vol.41 Issue 4, pp.476-492

Belge Tipi: Makale

Yayın Tarihi: 7/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000726357

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Nada F. ATTA | Mohammad H. BINSABT | Ekram H. EL-ADS | Ahmed GALAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2017 Vol.41 Issue 4, pp.476-492

Belge Tipi:

Makale

Yayın Tarihi:

7/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000726357

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527