Neurological outcome after cardiac arrest: a prospective study of the predictive ability of prognostic biomarkers neuron-specific enolase, glial fibrillary acidic protein, S-100B, and procalcitonin

Gülay OK; Demet AYDIN; Koray ERBÜYÜN; Canan GÜRSOY; Fatma TANELİ; Sema BİLGE; Gönül Dinç HORASAN

Makale detayları

Neurological outcome after cardiac arrest: a prospective study of the predictive ability of prognostic biomarkers neuron-specific enolase, glial fibrillary acidic protein, S-100B, and procalcitonin

Yazarlar:

Gülay OK | Demet AYDIN | Koray ERBÜYÜN | Canan GÜRSOY | Fatma TANELİ | Sema BİLGE | Gönül Dinç HORASAN

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 5, pp.1459-1468

Belge Tipi:

Makale

Yayın Tarihi:

9/2016

Belge Dili:

İngilizce

Document ID (Org No.):

2000751838

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: Factors affecting neurological outcome and the usefulness of neuron-specific enolase (NSE), S-100B, glial fibrillary acidic protein (GFAP), and procalcitonin (PCT) in predicting neurological outcomes were assessed in patients who survived at least 24 h after cardiopulmonary resuscitation (CPR).  Materials and methods: Thirty successfully resuscitated cardiac arrest patients were included in this prospective clinical study. The initial cardiac arrest rhythm, duration of CPR, return of spontaneous circulation time, administered doses of adrenaline, base excess, blood sugar, and hemodynamic parameters were recorded. Patients with Glasgow Outcome Scale (GOS) scores of 1-3 were defined as Group I and patients with GOS scores of 4-5 were defined as Group II. Serum NSE, GFAP, S-100B, and PCT levels were compared between the two groups shortly after CPR (hour 0) and at hours 12 and 24 of the postresuscitation period.  Results: Serum S-100B was significantly higher (P = 0.009) in Group II immediately after CPR. Serum S-100B and NSE after CPR at hours 0, 12, and 24 were significantly lower in patients who survived to hospital discharge. Serum PCT at hours 12 and 24 and serum S-100B after CPR at 0, 12, and 24 h reached 94.7% sensitivity. Serum NSE, GFAP, S-100B, and PCT specificities were lower than 50%.  Conclusion: In predicting neurological outcomes, serum S-100B has high sensitivity and low specificity immediately after CPR.

Makale detayları

Neurological outcome after cardiac arrest: a prospective study of the predictive ability of prognostic biomarkers neuron-specific enolase, glial fibrillary acidic protein, S-100B, and procalcitonin

Yazarlar: Gülay OK | Demet AYDIN | Koray ERBÜYÜN | Canan GÜRSOY | Fatma TANELİ | Sema BİLGE | Gönül Dinç HORASAN

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2016 Vol.46 Issue 5, pp.1459-1468

Belge Tipi: Makale

Yayın Tarihi: 9/2016

Belge Dili: İngilizce

Document ID (Org No.): 2000751838

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Gülay OK | Demet AYDIN | Koray ERBÜYÜN | Canan GÜRSOY | Fatma TANELİ | Sema BİLGE | Gönül Dinç HORASAN

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2016 Vol.46 Issue 5, pp.1459-1468

Belge Tipi:

Makale

Yayın Tarihi:

9/2016

Belge Dili:

İngilizce

Document ID (Org No.):

2000751838

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144