Chemistry of Secondary Metabolites (Production, Properties, Biological Activity, etc.): Solubility Study of the Interaction between Pamam G-3 Dendrimer and 5 Fluorouracil in Aqueous Solution

B. PALECZ; A. BUCZKOWSKI; L. B. ZAVODNIK

Makale detayları

Chemistry of Secondary Metabolites (Production, Properties, Biological Activity, etc.): Solubility Study of the Interaction between Pamam G-3 Dendrimer and 5 Fluorouracil in Aqueous Solution

Yazarlar:

B. PALECZ | A. BUCZKOWSKI | L. B. ZAVODNIK

Yayıncı:

İzzet KARA

Ana Başlıklar:

Yaşam bilimleri

Dergi:

International Journal of Secondary Metabolite 2014 Vol.1 Issue 1, pp.3-0

Belge Tipi:

Makale

Yayın Tarihi:

7/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000472067

Sıklık:

Üç Aylık

eISSN:

2148-6905

Özet:

 

Poly(amidoamine) dendrimers (PAMAM) are polymeric macromolecules that can find their use as carriers of small ligand molecules such as cosmetics and drugs. 5- Fluorouracil is a potent oncological drug, whose usage is limited because of its relatively high toxicity.The surface and internal layer groups in PAMAM dendrimer belonging to the third (G3) generation create an open-type structure, which facilitate small ligand molecules to bind with them.The formation equilibrium of PAMAM G3 dendrimer complex with an oncologic drug such as 5 fluorouracil (FU) in water at room temperature was examined. Using the results of the drug solubility in dendrimer solutions, the maximal number of drug molecules in the dendrimer-drug complex was evaluated. Solubility results show that PAMAM G3 dendrimer can transfer tens 5 fluorouracil molecules in aqueous solution.This research work was funded from the Polish budget appropriations for science in the years 2013-2015, project number IP2012 022372.

Makale detayları

Chemistry of Secondary Metabolites (Production, Properties, Biological Activity, etc.): Solubility Study of the Interaction between Pamam G-3 Dendrimer and 5 Fluorouracil in Aqueous Solution

Yazarlar: B. PALECZ | A. BUCZKOWSKI | L. B. ZAVODNIK

Yayıncı: İzzet KARA

Ana Başlıklar: Yaşam bilimleri

Dergi: International Journal of Secondary Metabolite 2014 Vol.1 Issue 1, pp.3-0

Belge Tipi: Makale

Yayın Tarihi: 7/2014

Belge Dili: İngilizce

Document ID (Org No.): 2000472067

Sıklık: Üç Aylık

eISSN: 2148-6905

Sayı

Yazarlar:

B. PALECZ | A. BUCZKOWSKI | L. B. ZAVODNIK

Yayıncı:

İzzet KARA

Ana Başlıklar:

Yaşam bilimleri

Dergi:

International Journal of Secondary Metabolite 2014 Vol.1 Issue 1, pp.3-0

Belge Tipi:

Makale

Yayın Tarihi:

7/2014

Belge Dili:

İngilizce

Document ID (Org No.):

2000472067

Sıklık:

Üç Aylık

eISSN:

2148-6905