The Effects of Natural and Artifical Sweeteners on Glucose Intolerance, Liver Enzymes and Oxidative Stress in Rats with Type 2 Diabetes

Merve Pehlivan; Eda Köksal

Makale detayları

The Effects of Natural and Artifical Sweeteners on Glucose Intolerance, Liver Enzymes and Oxidative Stress in Rats with Type 2 Diabetes

Yazarlar:

Merve Pehlivan | Eda Köksal

Yayıncı:

Gumushane University

Ana Başlıklar:

Klinik Beslenme

Dergi:

Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi Vol.13 Issue 4, pp.1518-1526

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001335128

pISSN:

2146-9954

Anahtar kelimeler:

Özet:

 The impacts of artificial and sweeteners on liver enzymes, glucose intolerance, and oxidative stress were investigated in the present research. Sixty adult male Wistar rats were indiscriminately distributed to two groups, involving 30 in each. The first group was made diabetic with streptozocin, and the second group was called the healthy control group. Then, these groups were divided into 3 different groups again and these groups were given 250 mgkg daily of Aspartame and Stevia and followed for 5 weeks to compare their effects. A comparison between the groups indicated that the diabetic stevia group had lower levels of aspartate aminotransferase AST, alanine aminotransferase ALT, blood glucose, and HbA1c values than the diabetic aspartame group p0.001. The diabetic aspartame group had higher levels of tumor necrosis factor-alpha TNF-alpha value than the stevia control p0.001. The aspartame control group had higher levels of interleukin 1 IL-1 than the healthy control group p0.001. The interleukin-6 IL-6 value of the diabetic aspartame group was found to be noticeably higher than the healthy control group p0.001. The total antioxidant capacity TAS of the diabetic, healthy control and stevia groups was found to be considerably higher than the diabetic and control aspartame groups p0.001. The total oxidant capacity TOS of the diabetic and control aspartame groups was notably high when compared to the value of the control stevia group p0.001. As a result, aspartame significantly increases AST, HbA1c, blood glucose, TNF-alpha, ALT, TOS, IL-1, and IL-6 figures compared to stevia but radically decreases TAS values.

 The impacts of artificial and sweeteners on liver enzymes, glucose intolerance, and oxidative stress were investigated in the present research. Sixty adult male Wistar rats were indiscriminately distributed to two groups, involving 30 in each. The first group was made diabetic with streptozocin, and the second group was called the healthy control group. Then, these groups were divided into 3 different groups again and these groups were given 250 mgkg daily of Aspartame and Stevia and followed for 5 weeks to compare their effects. A comparison between the groups indicated that the diabetic stevia group had lower levels of aspartate aminotransferase AST, alanine aminotransferase ALT, blood glucose, and HbA1c values than the diabetic aspartame group p0.001. The diabetic aspartame group had higher levels of tumor necrosis factor-alpha TNF-alpha value than the stevia control p0.001. The aspartame control group had higher levels of interleukin 1 IL-1 than the healthy control group p0.001. The interleukin-6 IL-6 value of the diabetic aspartame group was found to be noticeably higher than the healthy control group p0.001. The total antioxidant capacity TAS of the diabetic, healthy control and stevia groups was found to be considerably higher than the diabetic and control aspartame groups p0.001. The total oxidant capacity TOS of the diabetic and control aspartame groups was notably high when compared to the value of the control stevia group p0.001. As a result, aspartame significantly increases AST, HbA1c, blood glucose, TNF-alpha, ALT, TOS, IL-1, and IL-6 figures compared to stevia but radically decreases TAS values.

 The impacts of artificial and sweeteners on liver enzymes, glucose intolerance, and oxidative stress were investigated in the present research. Sixty adult male Wistar rats were indiscriminately distributed to two groups, involving 30 in each. The first group was made diabetic with streptozocin, and the second group was called the healthy control group. Then, these groups were divided into 3 different groups again and these groups were given 250 mgkg daily of Aspartame and Stevia and followed for 5 weeks to compare their effects. A comparison between the groups indicated that the diabetic stevia group had lower levels of aspartate aminotransferase AST, alanine aminotransferase ALT, blood glucose, and HbA1c values than the diabetic aspartame group p0.001. The diabetic aspartame group had higher levels of tumor necrosis factor-alpha TNF-alpha value than the stevia control p0.001. The aspartame control group had higher levels of interleukin 1 IL-1 than the healthy control group p0.001. The interleukin-6 IL-6 value of the diabetic aspartame group was found to be noticeably higher than the healthy control group p0.001. The total antioxidant capacity TAS of the diabetic, healthy control and stevia groups was found to be considerably higher than the diabetic and control aspartame groups p0.001. The total oxidant capacity TOS of the diabetic and control aspartame groups was notably high when compared to the value of the control stevia group p0.001. As a result, aspartame significantly increases AST, HbA1c, blood glucose, TNF-alpha, ALT, TOS, IL-1, and IL-6 figures compared to stevia but radically decreases TAS values.

 Bu çalışmanın amacı, doğal ve yapay tatlandırıcıların glukoz intoleransı, karaciğer enzimleri ve oksidatif stres üzerine etkisini araştırmaktır. Altmış adet erişkin erkek Wistar rat, rastgele her grupta 30 adet olacak şekilde 2 gruba ayrılmştır. İlk grup streptozosin ile diyabetik yapılmış, ikinci grup ise sağlıklı kontrol grubu olarak adlandırılmıştır. Daha sonrasında bu gruplar kendi aralarında tekrar 3 farklı gruba ayrılmış ve bu gruplaraAspartam ve Stevia günlük 250 mgkg şeklinde verilmiş ve etkilerini karşılaştırmak için 5 hafta boyunca takip edilmiştir Diyabetik aspartam grubu ile karşılaştırıldığında diyabetik stevia grubunun alanin aminotransferaz ALT, aspartat aminotransferaz AST, kan glukoz seviyeleri ve HbA1c değerleri diyabetik aspartam grubuna göre düşük bulunmuştur p0,001. Stevia kontrol grubuna göre diyabetik aspartam grubunda tümör nekroz faktörü-alfa TNF-alfa değeri yüksek saptanmıştır p0,001. Sağlıklı kontrol grubuna göre, aspartam kontrol grubunun interlökin 1 IL-1 değeri yüksek bulunmuştur p0,001. Diyabetik aspartam grubunun interlökin-6 IL-6 değeri ise sağlıklı kontrol grubundan anlamlı derecede yüksek saptanmıştır p0,001. Diyabetik, sağlıklı kontrol ve stevia gruplarının toplam antioksidan kapasitesi TAS, diyabetik ve kontrol aspartam gruplarından anlamlı derecede yüksek çıkmıştır p0,001. Diyabetik ve kontrol aspartam gruplarının toplam oksidan kapasitesi TOS, kontrol stevia grubundan anlamlı derecede yüksek bulunmuştur p0,001. Bu çalışmanın sonucuna göre aspartam ALT, AST, kan glukozu, HbA1c, TNF-alfa, IL-1, IL-6 ve TOS değerlerini steviaya göre anlamlı derecede yükseltirken, TAS değerlerini anlamlı derecede düşürmektedir.

Makale detayları

The Effects of Natural and Artifical Sweeteners on Glucose Intolerance, Liver Enzymes and Oxidative Stress in Rats with Type 2 Diabetes

Yazarlar:

Merve Pehlivan | Eda Köksal

Yayıncı:

Gumushane University

Ana Başlıklar:

Klinik Beslenme

Dergi:

Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi Vol.13 Issue 4, pp.1518-1526

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001335128

pISSN:

2146-9954

Sweeteners

Glucose Intolerance

Liver Enzymes

Oxidative StressTatlandırıcılar

Glukoz İntoleransı

Karaciğer Enzimleri

Oksidatif Stres

Sayı

Makale detayları

Yazarlar: Merve Pehlivan | Eda Köksal

Yayıncı: Gumushane University

Ana Başlıklar: Klinik Beslenme

Dergi: Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi Vol.13 Issue 4, pp.1518-1526

Belge Tipi: Makale

Yayın Tarihi: 12/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001335128

pISSN: 2146-9954

Sayı

Yazarlar:

Merve Pehlivan | Eda Köksal

Yayıncı:

Gumushane University

Ana Başlıklar:

Klinik Beslenme

Dergi:

Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi Vol.13 Issue 4, pp.1518-1526

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001335128

pISSN:

2146-9954